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UniProtKB - D3Z420 (D3Z420_MOUSE)

Entry version 61 (16 Jan 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Family with sequence similarity 186, member B

Gene

Fam186b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Family with sequence similarity 186, member BImported
Submitted name:
MCG18394Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam186bImported
ORF Names:mCG_18394Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3647604 Fam186b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000078907 Expressed in 12 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000104728

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili240 – 260Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IKH1 Eukaryota
ENOG411182R LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162031

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000112461

Identification of Orthologs from Complete Genome Data

More...OMAi		RQKKWAL

Database of Orthologous Groups

More...OrthoDBi		45971at2759

TreeFam database of animal gene trees

More...TreeFami		TF338344

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039332 FAM186A/FAM186B

The PANTHER Classification System

More...PANTHERi		PTHR33590 PTHR33590, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3Z420-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKDNPPHLV TPTSVKAIIS KIETAQLIRT QEDISTQLSD ILDNVNCAIN 
        60         70         80         90        100
RFQEELGYDL KERAKPHQPE QKGKKRFILL EKLAAFSDDA KAKEKHLYEI 
       110        120        130        140        150
LHWLGEWGDS LTYEIKDRSS EEDEALDEWI EVMEKVLPLS LMATKGGIES 
       160        170        180        190        200
LISLCSTLIE DQKKMTQRYK HNFWQDWHEK SPQNKEQGIP VPPSPEQMLQ 
       210        220        230        240        250
DKNTAHLNVS EVRSMLQELL DSTMFNKGEV KAIRYMSAVV ENLNKALTLQ 
       260        270        280        290        300
HKENKSLETK YKYLQVEKNK ELSTQRLHFQ KSIQVLESKR DALLKQVKIL 
       310        320        330        340        350
GDKYHHLLML KHTLEFQLNI AQPASGPEEP TKHFIHYLEP PEKEPLPGQG 
       360        370        380        390        400
TALEKEKQEP KEKGQAVSAL FSSPLTKAWH SGTTPAAPKP IFGTDTDSRV 
       410        420        430        440        450
RDVFVDRTEA LEPVLLHSEV PQIPTQWEKL GDMKDKDQGD HIQEEGAQSK 
       460        470        480        490        500
SLSPGSIRRR LLESHMGHWE EELNWETRRQ QWLQEEEMWL QRQKKWALLE 
       510        520        530        540        550
QEHQEKVRQW EAEAAARQQW QRLTQPEEEK PSPRKEQKAS SEMIFTTTSR 
       560        570        580        590        600
WKSLKKSEST PTPHCRAQSA HQSRSYILAS PHTQQPGQGT QRTLGSAEFL 
       610        620        630        640        650
QRPPTRQVSA KPKKSTSLPV TGTSILRRVS QVSLQQAPGT PKDKVYHIDM 
       660        670        680        690        700
EAQLKNLQVL GGSESEVALP QYLRSKALEV IAIAMDLSIL RLQYLCKKYI 
       710        720        730        740        750
QYRRFQSLRL EMIKHIGAIR QTRVTSKAQN LYLFLENIDH QQSLRLQAWA 
       760        770        780        790        800
DKQRDLEERH QECLHTMVAM FPKLQQEWNV HLSVPVLTHV KPVKSKSSSV 
       810        820        830        840        850
LLQRVRSSHS TTKHRPPPKP RESVPLPITG QQGSQMEAIW KADVASSSHP 
       860        870        880        890        900
IEKKTPTNMC WEQLGGYPDI PRLLVVDEHP SCPRSSVSFK ARSFSASSVQ 
       910        920        930        940 
RKEGQEPSEE LAGPVCKMSS QSLPGSICTK QEGSGSSSTH SIP
Length:943
Mass (Da):107,852
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DBDEA32522883A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHU0A0A2R8VHU0_MOUSE
Family with sequence similarity 186...
Fam186b
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC161198 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04136.1

NCBI Reference Sequences

More...RefSeqi		NP_001074723.1, NM_001081254.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.324745

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000109100; ENSMUSP00000104728; ENSMUSG00000078907

Database of genes from NCBI RefSeq genomes

More...GeneIDi		545136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:545136

UCSC genome browser

More...UCSCi		uc007xpf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161198 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04136.1
RefSeqiNP_001074723.1, NM_001081254.1
UniGeneiMm.324745

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104728

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109100; ENSMUSP00000104728; ENSMUSG00000078907
GeneIDi545136
KEGGimmu:545136
UCSCiuc007xpf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84070
MGIiMGI:3647604 Fam186b

Phylogenomic databases

eggNOGiENOG410IKH1 Eukaryota
ENOG411182R LUCA
GeneTreeiENSGT00940000162031
HOGENOMiHOG000112461
OMAiRQKKWAL
OrthoDBi45971at2759
TreeFamiTF338344

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000078907 Expressed in 12 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR039332 FAM186A/FAM186B
PANTHERiPTHR33590 PTHR33590, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z420_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z420
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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