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Protein

Selenoprotein N

Gene

Selenon

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H2O2, which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (By similarity). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein N1 Publication
Short name:
SelN1 Publication
Gene namesi
Name:SelenonImported
Synonyms:Seln1 Publication, Sepn1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2151208 Selenon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice show only subtle alterations in the muscle morphology, ultrastructure and contractility. They display increased muscle stress-sensitivity to physical exercise when performed under stress conditions such as a forced swimming test. Under these conditions, they develop muscle atrophy, predominantly affecting trunk muscles and leading to severe kyphosis (PubMed:21858002). The number of satellite cells in uninjured adult muscle is reduced. After one single cardiotoxin-induced injury, a correct restoration of the muscle fibers is seen in skeletal muscle, whereas after two successive injuries, regeneration is completely abolished (PubMed:21131290).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000043604043 – 557Selenoprotein NAdd BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiD3Z2R5
PeptideAtlasiD3Z2R5
PRIDEiD3Z2R5

PTM databases

iPTMnetiD3Z2R5
PhosphoSitePlusiD3Z2R5

Expressioni

Gene expression databases

BgeeiENSMUSG00000050989 Expressed in 254 organ(s), highest expression level in dorsal pancreas

Interactioni

Subunit structurei

Interacts with RYR1, RYR2 and RYR3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060026

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 102EF-handPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 112Poly-GluSequence analysis4
Compositional biasi208 – 211Poly-ProSequence analysis4

Domaini

The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGIC Eukaryota
ENOG410XS9C LUCA
GeneTreeiENSGT00390000005972
HOGENOMiHOG000007489
InParanoidiD3Z2R5
KOiK19874
OMAiLDTDQDM
OrthoDBiEOG091G0KDG
TreeFamiTF329622

Family and domain databases

InterProiView protein in InterPro
IPR002048 EF_hand_dom
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3Z2R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQARPAARR PHSPDPGAQP APPRRRARAL ALLGALLAAA AAVAAARACA
60 70 80 90 100
LLADAQAAAR QESALKVLGT DGLFLFSSLD TDQDMYISPE EFKPIAEKLT
110 120 130 140 150
GSVPVANYEE EELPHDPSEE TLTIEARFQP LLMETMTKSK DGFLGVSRLA
160 170 180 190 200
LSGLRNWTTA ASPSAAFAAR HFRPFLPPPG QELGQPWWII PGELSVFTGY
210 220 230 240 250
LSNNRFYPPP PKGKEVIIHR LLSMFHPRPF VKTRFAPQGT VACLTAISDS
260 270 280 290 300
YYTVMFRIHA EFQLSEPPDF PFWFSPGQFT GHIILSKDAT HIRDFRLFVP
310 320 330 340 350
NHRSLNVDME WLYGASETSN MEVDIGYVPQ MELEAVGPSV PSVILDEDGN
360 370 380 390 400
MIDSRLPSGE PLQFVFEEIK WHQELSWEEA ARRLEVAMYP FKKVNYLPFT
410 420 430 440 450
EAFDRARAEK KLVHSILLWG ALDDQSCUGS GRTLRETVLE SPPILTLLNE
460 470 480 490 500
SFISTWSLVK ELEDLQTQQE NPLHRQLAGL HLEKYSFPVE MMICLPNGTV
510 520 530 540 550
VHHINANYFL DITSMKPEDM ENNNVFSFSS SFEDPSTATY MQFLREGLRR

GLPLLQP
Length:557
Mass (Da):62,492
Last modified:April 13, 2016 - v2
Checksum:iD085928963DE8257
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei428Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669982 Genomic DNA No translation available.
CCDSiCCDS38917.1
RefSeqiNP_083376.2, NM_029100.2
UniGeneiMm.29773

Genome annotation databases

EnsembliENSMUST00000060435; ENSMUSP00000060026; ENSMUSG00000050989
GeneIDi74777
KEGGimmu:74777
UCSCiuc008vfk.1 mouse

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669982 Genomic DNA No translation available.
CCDSiCCDS38917.1
RefSeqiNP_083376.2, NM_029100.2
UniGeneiMm.29773

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060026

PTM databases

iPTMnetiD3Z2R5
PhosphoSitePlusiD3Z2R5

Proteomic databases

PaxDbiD3Z2R5
PeptideAtlasiD3Z2R5
PRIDEiD3Z2R5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060435; ENSMUSP00000060026; ENSMUSG00000050989
GeneIDi74777
KEGGimmu:74777
UCSCiuc008vfk.1 mouse

Organism-specific databases

CTDi57190
MGIiMGI:2151208 Selenon

Phylogenomic databases

eggNOGiENOG410IGIC Eukaryota
ENOG410XS9C LUCA
GeneTreeiENSGT00390000005972
HOGENOMiHOG000007489
InParanoidiD3Z2R5
KOiK19874
OMAiLDTDQDM
OrthoDBiEOG091G0KDG
TreeFamiTF329622

Miscellaneous databases

PROiPR:D3Z2R5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050989 Expressed in 254 organ(s), highest expression level in dorsal pancreas

Family and domain databases

InterProiView protein in InterPro
IPR002048 EF_hand_dom
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSELN_MOUSE
AccessioniPrimary (citable) accession number: D3Z2R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2016
Last sequence update: April 13, 2016
Last modified: November 7, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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