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Protein

Calcium homeostasis modulator protein 1

Gene

Calhm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.2 Publications

Activity regulationi

Inhibited by Gd3+, Ruthenium Red, and Zn2+ and partially inhibited by 2-aminoethoxydiphenyl borate.By similarity

GO - Molecular functioni

  • calcium activated cation channel activity Source: UniProtKB
  • identical protein binding Source: MGI
  • voltage-gated calcium channel activity Source: CACAO
  • voltage-gated ion channel activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium homeostasis modulator protein 1
Gene namesi
Name:Calhm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:3643383 Calhm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 48ExtracellularSequence analysisAdd BLAST11
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 107CytoplasmicSequence analysisAdd BLAST38
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 180ExtracellularSequence analysisAdd BLAST52
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 348CytoplasmicSequence analysisAdd BLAST147

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired perceptions of sweet, bitter and umami compounds. Mice are viable and fertile, with no visible morphological abnormalities in their taste buds or any altered expression of taste-related marker genes. They do however display a loss of both preference for sweet and umami compounds and for avoidance of bitter compounds. Perceptions of sour and salty tastes are unaffected. Reduced voltage-gated currents in type II cells and taste-evoked ATP release from taste buds without affecting the excitability of taste cells by taste stimuli. Elderly males and females do not show defects in spatial learning and memory retrieving.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004222391 – 348Calcium homeostasis modulator protein 1Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiD3Z291
PRIDEiD3Z291

PTM databases

iPTMnetiD3Z291
PhosphoSitePlusiD3Z291
SwissPalmiD3Z291

Expressioni

Tissue specificityi

Specifically expressed in type II taste bud cells. Not expressed in brain.3 Publications

Gene expression databases

BgeeiENSMUSG00000079258 Expressed in 8 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiD3Z291 baseline and differential

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107444

Family & Domainsi

Sequence similaritiesi

Belongs to the CALHM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG7G Eukaryota
ENOG410YNIM LUCA
GeneTreeiENSGT00530000062796
HOGENOMiHOG000111295
InParanoidiD3Z291
KOiK19738
OMAiIPCKDLF
OrthoDBiEOG091G09L8
PhylomeDBiD3Z291
TreeFamiTF329085

Family and domain databases

InterProiView protein in InterPro
IPR029569 CALHM
IPR029568 CALHM1
PANTHERiPTHR32261 PTHR32261, 1 hit
PTHR32261:SF2 PTHR32261:SF2, 1 hit
PfamiView protein in Pfam
PF14798 Ca_hom_mod, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKFRMIFQF LQSNQESFMN GICGIMALAS AQMYSAFDFN CPCLPGYNVV
60 70 80 90 100
YSLGILLTPP LVLFLLGLVM NNNISMLAEE WKRPAGRRAK DPAVLRYMFC
110 120 130 140 150
SMAQRALIAP VVWVAVTLLD GKCFLCAFCT AVPVATLGNG SLVPGLPAPE
160 170 180 190 200
LARLLARVPC PEIYDGNWLL AREVAVRYLR CISQALGWSF VLLTTLLAFV
210 220 230 240 250
VRSVRPCFTQ VAFLKSKYWS HYIDIERKLF DETCTEHAKA FAKVCIQQFF
260 270 280 290 300
EAMNHDLELG HTHGVLATAT ATATATEAVQ SPSDRTEEER EKLRGITDQG
310 320 330 340
TMNRLLTSWH KCKPPLRLGQ EAPLMSNGWA GGEPRPPRKE VATYFSKV
Length:348
Mass (Da):38,827
Last modified:April 20, 2010 - v1
Checksum:i338717B7C1F8C354
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124724 Genomic DNA No translation available.
CH466534 Genomic DNA Translation: EDL42030.1
CCDSiCCDS38015.1
RefSeqiNP_001074740.1, NM_001081271.1
UniGeneiMm.439624

Genome annotation databases

EnsembliENSMUST00000111813; ENSMUSP00000107444; ENSMUSG00000079258
GeneIDi546729
KEGGimmu:546729
UCSCiuc008hus.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124724 Genomic DNA No translation available.
CH466534 Genomic DNA Translation: EDL42030.1
CCDSiCCDS38015.1
RefSeqiNP_001074740.1, NM_001081271.1
UniGeneiMm.439624

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107444

PTM databases

iPTMnetiD3Z291
PhosphoSitePlusiD3Z291
SwissPalmiD3Z291

Proteomic databases

PaxDbiD3Z291
PRIDEiD3Z291

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111813; ENSMUSP00000107444; ENSMUSG00000079258
GeneIDi546729
KEGGimmu:546729
UCSCiuc008hus.1 mouse

Organism-specific databases

CTDi255022
MGIiMGI:3643383 Calhm1

Phylogenomic databases

eggNOGiENOG410IG7G Eukaryota
ENOG410YNIM LUCA
GeneTreeiENSGT00530000062796
HOGENOMiHOG000111295
InParanoidiD3Z291
KOiK19738
OMAiIPCKDLF
OrthoDBiEOG091G09L8
PhylomeDBiD3Z291
TreeFamiTF329085

Miscellaneous databases

PROiPR:D3Z291
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079258 Expressed in 8 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiD3Z291 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029569 CALHM
IPR029568 CALHM1
PANTHERiPTHR32261 PTHR32261, 1 hit
PTHR32261:SF2 PTHR32261:SF2, 1 hit
PfamiView protein in Pfam
PF14798 Ca_hom_mod, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAHM1_MOUSE
AccessioniPrimary (citable) accession number: D3Z291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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