Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanocortin-2 receptor accessory protein 2

Gene

Mrap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.2 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin-2 receptor accessory protein 2
Gene namesi
Name:Mrap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3609239 Mrap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Obesity. Mice are normal at birth, with normal weight gain and post-weaning food intake during early life, although young males trend toward greater weight and food intake with advancing age. Mice of both genders gradually become extremely obese on a diet of regular chow ad libitum.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004240271 – 207Melanocortin-2 receptor accessory protein 2Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei91PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiD3Z1Q2
PRIDEiD3Z1Q2

PTM databases

PhosphoSitePlusiD3Z1Q2

Expressioni

Tissue specificityi

Predominantly expressed in the brain, mainly in the pons and cerebellum but also in regions involved in energy homeostasis, such as the hypothalamus and brainstem.1 Publication

Gene expression databases

BgeeiENSMUSG00000042761 Expressed in 73 organ(s), highest expression level in pontine nuclear group
GenevisibleiD3Z1Q2 MM

Interactioni

Subunit structurei

Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R and MC5R (By similarity). Interacts with MC4R.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046271

Structurei

3D structure databases

SMRiD3Z1Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MRAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHNK Eukaryota
ENOG4111S4H LUCA
GeneTreeiENSGT00650000093438
HOGENOMiHOG000290703
InParanoidiD3Z1Q2
OMAiTGAPHQE
OrthoDBiEOG091G0J7D
TreeFamiTF338691

Family and domain databases

InterProiView protein in InterPro
IPR028111 MRAP
PANTHERiPTHR28675 PTHR28675, 1 hit
PfamiView protein in Pfam
PF15183 MRAP, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z1Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMSAQRLAS NRTSPQSPSN SDYTWEYEYY EIGPVSFEGL KAHKYSIVIG
60 70 80 90 100
FWVGLAVFVI FMFFVLTLLT KTGAPHQDNA ESSERRFRMN SFVSDFGKPL
110 120 130 140 150
ESDKVFSRQG NEESRSLFHC YINEVEHLDR VKVCHQTTAI DSDVHLQEAS
160 170 180 190 200
RSSGRPEEEL ARFMKFDIPN FVNTEQSSFG EDDLLISEAP VLLENKPVSQ

TSRIDLD
Length:207
Mass (Da):23,678
Last modified:October 3, 2012 - v2
Checksum:iBDCFE5947A30E85E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125370 Genomic DNA No translation available.
AC168882 Genomic DNA No translation available.
CCDSiCCDS52878.1
RefSeqiNP_001094952.2, NM_001101482.2
NP_001171202.1, NM_001177731.1
XP_006511237.1, XM_006511174.2
XP_006511238.1, XM_006511175.2
XP_006511239.1, XM_006511176.2
XP_006511240.1, XM_006511177.3
XP_006511241.1, XM_006511178.3
XP_006511242.1, XM_006511179.2
XP_006511243.1, XM_006511180.3
UniGeneiMm.335337

Genome annotation databases

EnsembliENSMUST00000049457; ENSMUSP00000046271; ENSMUSG00000042761
ENSMUST00000113149; ENSMUSP00000108774; ENSMUSG00000042761
ENSMUST00000179313; ENSMUSP00000135904; ENSMUSG00000042761
GeneIDi244958
KEGGimmu:244958
UCSCiuc012gxw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125370 Genomic DNA No translation available.
AC168882 Genomic DNA No translation available.
CCDSiCCDS52878.1
RefSeqiNP_001094952.2, NM_001101482.2
NP_001171202.1, NM_001177731.1
XP_006511237.1, XM_006511174.2
XP_006511238.1, XM_006511175.2
XP_006511239.1, XM_006511176.2
XP_006511240.1, XM_006511177.3
XP_006511241.1, XM_006511178.3
XP_006511242.1, XM_006511179.2
XP_006511243.1, XM_006511180.3
UniGeneiMm.335337

3D structure databases

SMRiD3Z1Q2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046271

PTM databases

PhosphoSitePlusiD3Z1Q2

Proteomic databases

PaxDbiD3Z1Q2
PRIDEiD3Z1Q2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049457; ENSMUSP00000046271; ENSMUSG00000042761
ENSMUST00000113149; ENSMUSP00000108774; ENSMUSG00000042761
ENSMUST00000179313; ENSMUSP00000135904; ENSMUSG00000042761
GeneIDi244958
KEGGimmu:244958
UCSCiuc012gxw.1 mouse

Organism-specific databases

CTDi112609
MGIiMGI:3609239 Mrap2

Phylogenomic databases

eggNOGiENOG410IHNK Eukaryota
ENOG4111S4H LUCA
GeneTreeiENSGT00650000093438
HOGENOMiHOG000290703
InParanoidiD3Z1Q2
OMAiTGAPHQE
OrthoDBiEOG091G0J7D
TreeFamiTF338691

Miscellaneous databases

PROiPR:D3Z1Q2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042761 Expressed in 73 organ(s), highest expression level in pontine nuclear group
GenevisibleiD3Z1Q2 MM

Family and domain databases

InterProiView protein in InterPro
IPR028111 MRAP
PANTHERiPTHR28675 PTHR28675, 1 hit
PfamiView protein in Pfam
PF15183 MRAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRAP2_MOUSE
AccessioniPrimary (citable) accession number: D3Z1Q2
Secondary accession number(s): D3YVA7, D3YZ75, D3Z746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again