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Entry version 55 (08 May 2019)
Sequence version 1 (20 Apr 2010)
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Protein

Cardiac-enriched FHL2-interacting protein

Gene

CEFIP

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cardiac-enriched FHL2-interacting protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEFIP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3588196 3425401B19Rik

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004445781 – 1412Cardiac-enriched FHL2-interacting proteinAdd BLAST1412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphothreonineBy similarity1
Modified residuei328PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1
Modified residuei813PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3Z1D3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3Z1D3

PRoteomics IDEntifications database

More...
PRIDEi
D3Z1D3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3Z1D3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3Z1D3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart and skeletal muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071540 Expressed in 16 organ(s), highest expression level in interventricular septum

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FHL2.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093741

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3Z1D3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIUF Eukaryota
ENOG4111R16 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111333

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111690

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3Z1D3

Identification of Orthologs from Complete Genome Data

More...
OMAi
PIIPTKH

Database of Orthologous Groups

More...
OrthoDBi
416362at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3Z1D3

TreeFam database of animal gene trees

More...
TreeFami
TF336978

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027838 DUF4585

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15232 DUF4585, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3Z1D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQGNKKCTD GFSDTSSIGS VLDEADREVS NLTDRAFRSL CISEDTSFHD
60 70 80 90 100
SDLALSPDVT SQVSGTFHQE TVGHANRKSG IWSQLPSQGT EHSGWAATFQ
110 120 130 140 150
QQPKYVQGEE KYPKTSPLPT PVQRRLEVPI SGLRSSSKPI SKVSSLIRSF
160 170 180 190 200
DRTETQSCDS RPPPSKPPAL KNPPKFAHPP ESGVNFCFDS AFLTVRRVPA
210 220 230 240 250
EVSNTHQGSH QSGRAPGEQE SPKNPEIASH SSDSLLRTPD HVAGSFEPRY
260 270 280 290 300
PSPPLKPATA EPGRGKEWIP RRTFLHSENS AFESWDTHQP KLRERKDIAE
310 320 330 340 350
TTPESKAPKH YEDMPLLKEP YPAESKGSPY QARANCAQEE NRSPSGSQST
360 370 380 390 400
SGAWGARDPG SQLFPVEGNA SQIDPQVKRS KAPWRKPKTG KGGTDGPPDA
410 420 430 440 450
LEDKKQPNRR GLPLYSKLNP QGQLPENGVL DMPEESNDHY NPPFNISKLL
460 470 480 490 500
TPIISTKHVL ETSDTQPVEI SPSPPGQLNG YQEKESSEAQ SRDSYKSKAP
510 520 530 540 550
SLLFNLKDVR KRVKSTYSPL PLLKGFDEKT RGKLDSKQEP LSNGVTLPDG
560 570 580 590 600
LEENPPTELL PDNVPGVLHS STQKDPAINS RESFAVSHPT FSSPSASSQT
610 620 630 640 650
HFCVNGEAAE SNSNEKEEAN GESELDPSKG GGHPDCRENL PRKHLSLKLF
660 670 680 690 700
NRESEMGPAM AEMKPHQLEN GLSRSVSQET ETERETGFQS LPLNQKFSPG
710 720 730 740 750
PLSPEEEDVF YSDSQSDFTP CRQTKAKFST SSSDQSFASF EDQQKVCFTE
760 770 780 790 800
GPQEDRKSHV SAGDKQRDET AVEKEESQQC ASRNEHRGVD EQRQEEIQRK
810 820 830 840 850
AQGVSGGRPR KASAEDLSAR GSWMGADKDT AHTHAKDPTP LPASTNKHRL
860 870 880 890 900
FPIKDNTLRA TPVIKPIILP LLRTVSSEDS LSSGHQENEL PKQLWGEDAG
910 920 930 940 950
GLSASESQEM PNTPLSNNDV PGTQHRCMVC EDVQEDPVHT AAQDETSQQT
960 970 980 990 1000
RKGSFSFLPP VEEENRMKPS PDTAGEGLAQ EKSKSADLGK LGVPQRIPTI
1010 1020 1030 1040 1050
ALLPDDLEDS PPSLPQHTYW EEQGFKGHFL SAPRAGPSGR RLVPSEAETS
1060 1070 1080 1090 1100
PNPSSLGESS TCSPAASSIW EEASQAAGEH WQRQEPPGPN PWASPGPTGL
1110 1120 1130 1140 1150
TRREDMTHGL TWEAEGSDPS DFRALSPRGI LLADAAEKPE PPALLEKAAG
1160 1170 1180 1190 1200
KPPAVPPKTE KALRRAKKLA SKRRKSDQLL EKHTEAWEGK SFTEDTQGTE
1210 1220 1230 1240 1250
RRPVSPGKGP RPRFPAIRSL PPPTHRHSVS CGWEPTGRRP WGPQSLTPLP
1260 1270 1280 1290 1300
PYPATQKVLQ DPQSGQYFVF DVPLQVKIKT FYDPETGKYV KVSVPSSEEA
1310 1320 1330 1340 1350
SSEPPLQDAL AAPYLLYPGF RPVPVTSVMP LRCSSQLAAP TFLRQGSGHR
1360 1370 1380 1390 1400
PQSSQGSRLQ PPPERLGEST QHASGQCPRG PSHSPEKESA EAPRLSIIST
1410
DDLEDFATEG VS
Length:1,412
Mass (Da):154,478
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0080CC0DAB94AC93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT009541 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49437.1

NCBI Reference Sequences

More...
RefSeqi
NP_001182026.1, NM_001195097.1
XP_006518377.1, XM_006518314.3
XP_006518378.1, XM_006518315.3
XP_006518379.1, XM_006518316.3
XP_006518380.1, XM_006518317.3
XP_006518381.1, XM_006518318.3
XP_006518382.1, XM_006518319.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096038; ENSMUSP00000093741; ENSMUSG00000071540

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100504518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100504518

UCSC genome browser

More...
UCSCi
uc007szg.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009541 Genomic DNA No translation available.
CCDSiCCDS49437.1
RefSeqiNP_001182026.1, NM_001195097.1
XP_006518377.1, XM_006518314.3
XP_006518378.1, XM_006518315.3
XP_006518379.1, XM_006518316.3
XP_006518380.1, XM_006518317.3
XP_006518381.1, XM_006518318.3
XP_006518382.1, XM_006518319.3

3D structure databases

SMRiD3Z1D3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093741

PTM databases

iPTMnetiD3Z1D3
PhosphoSitePlusiD3Z1D3

Proteomic databases

MaxQBiD3Z1D3
PaxDbiD3Z1D3
PRIDEiD3Z1D3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096038; ENSMUSP00000093741; ENSMUSG00000071540
GeneIDi100504518
KEGGimmu:100504518
UCSCiuc007szg.2 mouse

Organism-specific databases

MGIiMGI:3588196 3425401B19Rik

Phylogenomic databases

eggNOGiENOG410IIUF Eukaryota
ENOG4111R16 LUCA
GeneTreeiENSGT00730000111333
HOGENOMiHOG000111690
InParanoidiD3Z1D3
OMAiPIIPTKH
OrthoDBi416362at2759
PhylomeDBiD3Z1D3
TreeFamiTF336978

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000071540 Expressed in 16 organ(s), highest expression level in interventricular septum

Family and domain databases

InterProiView protein in InterPro
IPR027838 DUF4585
PfamiView protein in Pfam
PF15232 DUF4585, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEFIP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z1D3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: April 20, 2010
Last modified: May 8, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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