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Protein
Submitted name:

A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6

Gene

Adamts6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • aorta development Source: MGI
  • cardiac septum development Source: MGI
  • coronary vasculature development Source: MGI
  • heart development Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPSiM12.248

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6Imported
Gene namesi
Name:Adamts6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347348 Adamts6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501508851718 – 1117Sequence analysisAdd BLAST1100

Keywords - PTMi

Disulfide bondSAAS annotation

PTM databases

PhosphoSitePlusiD3Z1A5

Expressioni

Gene expression databases

BgeeiENSMUSG00000046169 Expressed in 19 organ(s), highest expression level in fibroblast
GenevisibleiD3Z1A5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064570

Structurei

3D structure databases

ProteinModelPortaliD3Z1A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 468Peptidase M12BInterPro annotationAdd BLAST219
Domaini1079 – 1117PLACInterPro annotationAdd BLAST39

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
KOG4597 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
HOGENOMiHOG000004800
InParanoidiD3Z1A5
KOiK08621
OMAiGWCYQGD
OrthoDBiEOG091G14M8
PhylomeDBiD3Z1A5
TreeFamiTF313537

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00209 TSP1, 5 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3Z1A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEISWKTLTW ILSLIMASSE FYSDHRLSYS SQEEFLTYLE HYQLTIPIRV
60 70 80 90 100
DQNGAFLSFT VKNDKHSRRR RSMDLLDPQQ AVSKLFFKLS AYGKHFHLNL
110 120 130 140 150
TLNTNFVSKH FTVEYWGKDG PQWKHDFLDN CHYTGYLQDQ HSTTKVALSN
160 170 180 190 200
CVGLHGIIAT EDEEYFIEPL KNTTEDSKHF SYENGHPHVI YKKSTLQQQH
210 220 230 240 250
IYDHSHCGVS DLTGSGKPWW LNKTSSFPSL PPINDTHIHH RKRRSVSTER
260 270 280 290 300
FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA
310 320 330 340 350
RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH
360 370 380 390 400
DNAVLITRYD ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT
410 420 430 440 450
IAHEIGHNFG MNHDGIGNSC GTKGHEAAKL MAAHITANTN PFSWSACSRD
460 470 480 490 500
YITSFLDSGR GTCLDNEPPK RDFLYPAVAP GQVYDADEQC RFQYGATSRQ
510 520 530 540 550
CKYGEVCREL WCLSKSNRCV TNSIPAAEGT LCQTGNIEKG WCYQGDCVPF
560 570 580 590 600
GTWPQSIDGG WGSWSLWGEC SRTCGGGVSS SLRHCDSPAP SGGGKYCLGE
610 620 630 640 650
RKRYRSCNTD PCPLGSRDFR EKQCADFDSM PFRGKHYNWK PYTGGGVKPC
660 670 680 690 700
ALNCLAEGYN FYTERAPAVI DGTQCNADSL DICINGECKH VGCDNILGSD
710 720 730 740 750
AREDRCRVCG GDGSTCDAIE GFFNDSLPRG GYMEVVQIPR GSVHIEVREV
760 770 780 790 800
SMSKNYIALK SEGDDYYING AWTIDWPRKF DVSGTAFHYK RPTDEPESLE
810 820 830 840 850
ALGPTSENLI VMVLLQEQNL GIRYKFNVPI VRTGSGDNEV GFMWTYQPWA
860 870 880 890 900
ECSATCAGGV QRQEVVCKRL DDNSIVQNNF CDPDSKPPEN QRACNTEPCP
910 920 930 940 950
PEWFIGDWLE CSKTCDGGMR TRAVLCIRKV GPSEEETLDY GDCLTHRPVE
960 970 980 990 1000
KESCNNQSCP PQWVALDWSE CTPKCGSGFK HRIVLCKSSD LSKTFPAAQC
1010 1020 1030 1040 1050
PEESKPPARI RCSLGRCPPP RWVTGDWGQC SAQCGLGQQM RTVQCLSYTG
1060 1070 1080 1090 1100
QASVDCPETV RPPSMQQCDS KCDSTPLSST EECKDVNKVA YCPLVLKFKF
1110
CSRAYFRQMC CKTCQGH
Length:1,117
Mass (Da):125,059
Last modified:April 20, 2010 - v1
Checksum:i00B3271CD1D84EB5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YEC9A0A286YEC9_MOUSE
A disintegrin-like and metallopepti...
Adamts6
468Annotation score:
A0A286YCD8A0A286YCD8_MOUSE
A disintegrin-like and metallopepti...
Adamts6
292Annotation score:
A0A286YCZ1A0A286YCZ1_MOUSE
A disintegrin-like and metallopepti...
Adamts6
96Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154830 Genomic DNA No translation available.
AC165950 Genomic DNA No translation available.
RefSeqiNP_001074489.1, NM_001081020.2
XP_011242913.1, XM_011244611.2
UniGeneiMm.208125

Genome annotation databases

EnsembliENSMUST00000065766; ENSMUSP00000064570; ENSMUSG00000046169
ENSMUST00000224208; ENSMUSP00000153359; ENSMUSG00000046169
GeneIDi108154
KEGGimmu:108154
UCSCiuc007rti.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154830 Genomic DNA No translation available.
AC165950 Genomic DNA No translation available.
RefSeqiNP_001074489.1, NM_001081020.2
XP_011242913.1, XM_011244611.2
UniGeneiMm.208125

3D structure databases

ProteinModelPortaliD3Z1A5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064570

Protein family/group databases

MEROPSiM12.248

PTM databases

PhosphoSitePlusiD3Z1A5

Protocols and materials databases

DNASUi108154
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065766; ENSMUSP00000064570; ENSMUSG00000046169
ENSMUST00000224208; ENSMUSP00000153359; ENSMUSG00000046169
GeneIDi108154
KEGGimmu:108154
UCSCiuc007rti.1 mouse

Organism-specific databases

CTDi11174
MGIiMGI:1347348 Adamts6

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
KOG4597 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
HOGENOMiHOG000004800
InParanoidiD3Z1A5
KOiK08621
OMAiGWCYQGD
OrthoDBiEOG091G14M8
PhylomeDBiD3Z1A5
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046169 Expressed in 19 organ(s), highest expression level in fibroblast
GenevisibleiD3Z1A5 MM

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00209 TSP1, 5 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiD3Z1A5_MOUSE
AccessioniPrimary (citable) accession number: D3Z1A5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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