UniProtKB - D3Z0K8 (D3Z0K8_MOUSE)
Protein
Thioredoxin-disulfide reductase
Gene
Txnrd2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:1.8.1.9ARBA annotation
Cofactori
FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 79 | FADUniRule annotation | 1 | |
Binding sitei | 301 | NAD; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 343 | FADUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 209 – 216 | NADUniRule annotation | 8 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- thioredoxin-disulfide reductase activity Source: UniProtKB-EC
GO - Biological processi
- cell redox homeostasis Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | FADUniRule annotationARBA annotation, Flavoprotein, NADUniRule annotation, Nucleotide-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Txnrd2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1347023, Txnrd2 |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 70 ↔ 75 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
jPOSTi | D3Z0K8 |
PeptideAtlasi | D3Z0K8 |
PRIDEi | D3Z0K8 |
PTM databases
SwissPalmi | D3Z0K8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000075704, Expressed in blood and 283 other tissues |
ExpressionAtlasi | D3Z0K8, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 359 | Pyr_redox_2InterPro annotationAdd BLAST | 317 | |
Domaini | 379 – 466 | Pyr_redox_dimInterPro annotationAdd BLAST | 88 |
Sequence similaritiesi
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotationARBA annotation
Keywords - Domaini
Redox-active centerUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158832 |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR016156, FAD/NAD-linked_Rdtase_dimer_sf IPR001100, Pyr_nuc-diS_OxRdtase IPR004099, Pyr_nucl-diS_OxRdtase_dimer IPR012999, Pyr_OxRdtase_I_AS IPR006338, Thioredoxin/glutathione_Rdtase |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF02852, Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350, Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit SSF55424, SSF55424, 1 hit |
TIGRFAMsi | TIGR01438, TGR, 1 hit |
PROSITEi | View protein in PROSITE PS00076, PYRIDINE_REDOX_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
D3Z0K8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAMVAAMVA ALRGPSRRFR PRTRALTRGT RGAASAAGGQ QSFDLLVIGG
60 70 80 90 100
GSGGLACAKE GTKWGLGGTC VNVGCIPKKL MHQAALLGGM IRDAHHYGWE
110 120 130 140 150
VAQPVQHNWK TMAEAVQNHV KSLNWGHRVQ LQDRKVKYFN IKASFVDEHT
160 170 180 190 200
VRGVDKGGKA TLLSAEHIVI ATGGRPRYPT QVKGALEYGI TSDDIFWLKE
210 220 230 240 250
SPGKTLVVGA SYVALECAGF LTGIGLDTTV MMRSIPLRGF DQQMSSLVTE
260 270 280 290 300
HMESHGTQFL KGCVPSHIKK LPTNQLQVTW EDHASGKEDT GTFDTVLWAI
310 320 330 340 350
GRVPETRTLN LEKAGISTNP KNQKIIVDAQ EATSVPHIYA IGDVAEGRPE
360 370 380 390 400
LTPTAIKAGK LLAQRLFGKS STLMDYSNVP TTVFTPLEYG CVGLSEEEAV
410 420 430 440 450
ALHGQEHVEV YHAYYKPLEF TVADRDASQC YIKMVCMREP PQLVLGLHFL
460
GPNAGEVTQG FALGIK
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9JLT4 | TRXR2_MOUSE | Thioredoxin reductase 2, mitochondr... | Txnrd2 Trxr2 | 524 | Annotation score: | ||
A0A0M3HEQ0 | A0A0M3HEQ0_MOUSE | Thioredoxin-disulfide reductase | Txnrd2 | 527 | Annotation score: | ||
A0A0U1RPV8 | A0A0U1RPV8_MOUSE | Thioredoxin-disulfide reductase | Txnrd2 | 496 | Annotation score: | ||
A0A0U1RQA4 | A0A0U1RQA4_MOUSE | Thioredoxin-disulfide reductase | Txnrd2 | 505 | Annotation score: | ||
J3QMQ8 | J3QMQ8_MOUSE | Thioredoxin-disulfide reductase | Txnrd2 | 522 | Annotation score: | ||
J3QMN4 | J3QMN4_MOUSE | Thioredoxin-disulfide reductase | Txnrd2 | 491 | Annotation score: | ||
Q9D8I4 | Q9D8I4_MOUSE | Thioredoxin reductase 2, mitochondr... | Txnrd2 | 101 | Annotation score: | ||
A0A0M3HEP9 | A0A0M3HEP9_MOUSE | Thioredoxin reductase 2, mitochondr... | Txnrd2 | 359 | Annotation score: | ||
A0A0U1RPC6 | A0A0U1RPC6_MOUSE | Thioredoxin reductase 2, mitochondr... | Txnrd2 | 165 | Annotation score: | ||
A0A0U1RPS1 | A0A0U1RPS1_MOUSE | Thioredoxin reductase 2, mitochondr... | Txnrd2 | 123 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133487 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000115605; ENSMUSP00000111268; ENSMUSG00000075704 |
Keywords - Coding sequence diversityi
SelenocysteineARBA annotationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133487 Genomic DNA No translation available. |
3D structure databases
SMRi | D3Z0K8 |
ModBasei | Search... |
PTM databases
SwissPalmi | D3Z0K8 |
Proteomic databases
jPOSTi | D3Z0K8 |
PeptideAtlasi | D3Z0K8 |
PRIDEi | D3Z0K8 |
Protocols and materials databases
Antibodypediai | 230, 244 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000115605; ENSMUSP00000111268; ENSMUSG00000075704 |
Organism-specific databases
MGIi | MGI:1347023, Txnrd2 |
Phylogenomic databases
GeneTreei | ENSGT00940000158832 |
Miscellaneous databases
ChiTaRSi | Txnrd2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075704, Expressed in blood and 283 other tissues |
ExpressionAtlasi | D3Z0K8, baseline and differential |
Family and domain databases
Gene3Di | 3.30.390.30, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR016156, FAD/NAD-linked_Rdtase_dimer_sf IPR001100, Pyr_nuc-diS_OxRdtase IPR004099, Pyr_nucl-diS_OxRdtase_dimer IPR012999, Pyr_OxRdtase_I_AS IPR006338, Thioredoxin/glutathione_Rdtase |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF02852, Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350, Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit SSF55424, SSF55424, 1 hit |
TIGRFAMsi | TIGR01438, TGR, 1 hit |
PROSITEi | View protein in PROSITE PS00076, PYRIDINE_REDOX_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3Z0K8_MOUSE | |
Accessioni | D3Z0K8Primary (citable) accession number: D3Z0K8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | February 17, 2016 | |
Last modified: | October 7, 2020 | |
This is version 77 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |