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Entry version 55 (02 Jun 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Pleckstrin homology-like domain family B member 2

Gene

Phldb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pleckstrin homology-like domain family B member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Phldb2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444981, Phldb2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3Z069

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3Z069

PeptideAtlas

More...
PeptideAtlasi
D3Z069

PRoteomics IDEntifications database

More...
PRIDEi
D3Z069

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
373370

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033149, Expressed in urothelium and 282 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3Z069, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3Z069

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59
Regioni109 – 132DisorderedSequence analysisAdd BLAST24
Regioni173 – 199DisorderedSequence analysisAdd BLAST27
Regioni235 – 293DisorderedSequence analysisAdd BLAST59
Regioni309 – 335DisorderedSequence analysisAdd BLAST27
Regioni433 – 469DisorderedSequence analysisAdd BLAST37
Regioni910 – 979DisorderedSequence analysisAdd BLAST70
Regioni1090 – 1113DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili469 – 492Sequence analysisAdd BLAST24
Coiled coili628 – 662Sequence analysisAdd BLAST35
Coiled coili681 – 733Sequence analysisAdd BLAST53
Coiled coili763 – 812Sequence analysisAdd BLAST50
Coiled coili828 – 848Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 34Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi173 – 188Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi235 – 263Polar residuesSequence analysisAdd BLAST29
Compositional biasi264 – 278Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi279 – 293Polar residuesSequence analysisAdd BLAST15
Compositional biasi309 – 327Polar residuesSequence analysisAdd BLAST19
Compositional biasi440 – 462Polar residuesSequence analysisAdd BLAST23
Compositional biasi919 – 938Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi941 – 979Polar residuesSequence analysisAdd BLAST39

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156371

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3Z069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGMDPRVS SENHQKIPME EEDEAREEPK NGGADDPEPF GSSHIMAEDS
60 70 80 90 100
HMQKQLEFQN GSLEEGFVVR SLENEPQNMM ESLSPRKYSS SLKFKANGDY
110 120 130 140 150
SGSYLTLSQP VSAKRSPSPM GTSVRSSPSL AKIQGSKQFC DGIDKNISMK
160 170 180 190 200
PPISFLSSAA SLGGYPLGKA DLDHYTGRDS ERSTRLSEKP PYSRYSSRNK
210 220 230 240 250
SHDSVYFLGG LEGRKTSGSL LTMWNGNSLS CTGSSPISRS GAASMPSSPK
260 270 280 290 300
QVRKMNLQDH STLQPRLSRH KEPASENVSV RTRKYSGSSL SNMGAYSRSL
310 320 330 340 350
PRLYKATDNQ MSPLSLPPRS SLGNSRRGQL GEKDLPHSLV DSDNYLNFSS
360 370 380 390 400
LSSGASPYKT CLSEGNPYVS SALSVPASPR VARKMLLAST SSDDFDRASY
410 420 430 440 450
SGTSPSHSFI SGEPDRVLVA RRNFSCGSME LDDSDLESLR QSSETPQPVL
460 470 480 490 500
RERKSSISSI SGRDDLMDYH RRQREERLRE QEMERLERQR LETILSLCAE
510 520 530 540 550
YTKPEGRRLS AGTTVADVQK INKELEKLQL SDEESVFEDA LVCPDARYRC
560 570 580 590 600
HRKGSLQDVD VAGFGNLGHS ASFLAPRGSR SDELLGDLTR TPPSSSAAFL
610 620 630 640 650
KATNESSYLS ILPKTPEDIG EEQRTQELAA MEDARMVILN NLEELEQKIK
660 670 680 690 700
DINDQMDESS RELDMECALL DGEQKSETAE LMKEKEILDH LNRKITELEK
710 720 730 740 750
NIVGEKTKEK VKLDAEREKL ERLQELYSEQ KTQLDNCPES MREQLQQQLK
760 770 780 790 800
RDADLLDVES KHFEDLEFQQ LEHESRLDEE KENLTQQLLR EVAEYQRNIV
810 820 830 840 850
ARKEKISALK KQASHIVQQA QREQDHFVKE KNNLIMMLQR EKENLCNLEK
860 870 880 890 900
KYSSLTGGKG FPINPNTLKE GYISVNEINE SCGNSTNLSP STQFPADADA
910 920 930 940 950
AVTEPALAVP VSQPQSSEHF RSLEERKKQH KEGLYLSDTL PRKKTTPSLS
960 970 980 990 1000
PHFSSATMGR STTPKAHLPL GQSNSCGSVL PHSLATMTKD SESRRMLRGY
1010 1020 1030 1040 1050
NHQQMSEGQR QKPEFYSRTA SESNVYLNSF HYPDRSYKDQ AYDTLSLDSS
1060 1070 1080 1090 1100
DSMETSISAC SPDNISSAST SNIARIEEME RLLKQAHAEK TRLLESRERE
1110 1120 1130
MEAKKRALEE EKRRREILEK RLQEETSQRQ K
Length:1,131
Mass (Da):127,176
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4828FB14398E7937
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K1N2PHLB2_MOUSE
Pleckstrin homology-like domain fam...
Phldb2 Ll5b
1,249Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QU68F6QU68_MOUSE
Pleckstrin homology-like domain fam...
Phldb2
565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z231D3Z231_MOUSE
Pleckstrin homology-like domain fam...
Phldb2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1131Imported1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000134802; ENSMUSP00000123284; ENSMUSG00000033149

UCSC genome browser

More...
UCSCi
uc007zjc.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiD3Z069
ModBaseiSearch...

Proteomic databases

jPOSTiD3Z069
MaxQBiD3Z069
PeptideAtlasiD3Z069
PRIDEiD3Z069
ProteomicsDBi373370

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34806, 37 antibodies

Genome annotation databases

EnsembliENSMUST00000134802; ENSMUSP00000123284; ENSMUSG00000033149
UCSCiuc007zjc.1, mouse

Organism-specific databases

MGIiMGI:2444981, Phldb2

Phylogenomic databases

GeneTreeiENSGT00940000156371

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Phldb2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033149, Expressed in urothelium and 282 other tissues
ExpressionAtlasiD3Z069, baseline and differential

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z069_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z069
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 2, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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