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Entry version 92 (02 Jun 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

SLIT-ROBO Rho GTPase-activating protein 1

Gene

Srgap1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SLIT-ROBO Rho GTPase-activating protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Srgap1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152936, Srgap1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3YZW1

PeptideAtlas

More...
PeptideAtlasi
D3YZW1

PRoteomics IDEntifications database

More...
PRIDEi
D3YZW1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
312364

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020121, Expressed in cortical plate and 215 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YZW1, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YZW1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 314F-BARInterPro annotationAdd BLAST296
Domaini506 – 694Rho-GAPInterPro annotationAdd BLAST189
Domaini743 – 802SH3InterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni475 – 496DisorderedSequence analysisAdd BLAST22
Regioni808 – 954DisorderedSequence analysisAdd BLAST147
Regioni997 – 1036DisorderedSequence analysisAdd BLAST40
Regioni1051 – 1085DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili7 – 34Sequence analysisAdd BLAST28
Coiled coili352 – 379Sequence analysisAdd BLAST28
Coiled coili959 – 979Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi808 – 830Polar residuesSequence analysisAdd BLAST23
Compositional biasi831 – 857Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi933 – 947Polar residuesSequence analysisAdd BLAST15
Compositional biasi997 – 1013Polar residuesSequence analysisAdd BLAST17
Compositional biasi1021 – 1036Polar residuesSequence analysisAdd BLAST16
Compositional biasi1069 – 1085Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005715_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
1245523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3YZW1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07683, F-BAR_srGAP1, 1 hit
cd11955, SH3_srGAP1-3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR001060, FCH_dom
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035648, srGAP1/2/3_SH3
IPR037451, srGAP1_F-BAR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00611, FCH, 1 hit
PF00620, RhoGAP, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00055, FCH, 1 hit
SM00324, RhoGAP, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit
SSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741, F_BAR, 1 hit
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3YZW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTPSRFKKD KEIIAEYESQ VKEIRAQLVE QQKCLEQQTE MRVQLLQDLQ
60 70 80 90 100
DFFRKKAEIE TEYSRNLEKL AERFMAKTRS TKDHQQFKKD QNLLSPVNCW
110 120 130 140 150
YLLLNQVRRE SKDHATLSDI YLNNVIMRFM QISEDSTRMF KKSKEIAFQL
160 170 180 190 200
HEDLMKVLNE LYTVMKTYHM YHSESISAES KLKEAEKQEE KQIGRSGDPV
210 220 230 240 250
FHIRLEERHQ RRSSVKKIEK MKEKRQAKYS ENKLKSIKAR NEYLLTLEAT
260 270 280 290 300
NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTYLSAEYN LETSRHEGLD
310 320 330 340 350
IIENAVDNLE PRSDKQRFME MYPAAFCPPM KFEFQSHMGD EVCQVSAQQP
360 370 380 390 400
VQAELMLRNQ QLQSRLATLK IESEEVKKTT EATLQTIQDM VTIEDYDVSE
410 420 430 440 450
CFQHSRSTES VKSTVSETYL SKPSIAKRRA NQQETEQFYF MKLREFLEGS
460 470 480 490 500
NLITKLQAKH DLLQRTLGEG HRAEYMTTRP PNVPPKPQKH RKSRPRSQYN
510 520 530 540 550
AKLFNGDLET FVKDSGQVIP LIVESCIRFI NLYGLQHQGI FRVSGSQVEV
560 570 580 590 600
NDIKNSFERG ENPLSDEQSN HDINSVAGVL KLYFRGLENP LFPKERFTDL
610 620 630 640 650
ISCIRIDNLY ERALHIRKLL LTLPRSVLIV MRYLFAFLNH LSQYSDENMM
660 670 680 690 700
DPYNLAICFG PTLMPVPEIQ DQVSCQAHVN EIVKTIIIHH ETIFPDAKEL
710 720 730 740 750
DGPVYEKCMA GGDYCDSPYS EHGTLEEVDQ DAGTEPHTSE DECEPIEAIA
760 770 780 790 800
KFDYVGRSAR ELSFKKGASL LLYHRASEDW WEGRHNGIDG LVPHQYIVVQ
810 820 830 840 850
DMDDTFSDTL SQKADSEASS GPVTEDKSSS KDMNSPTDRH SDSYLARQRK
860 870 880 890 900
RGEPPPPGRR PGRTSDGHCP LHPPHALSNS SIDLGSPNLA SHPRGLLQNR
910 920 930 940 950
GLNNDSPERR RRPGHGSLTN ISRHDSLKKI DSPPIRRSTS SGQYTGFNDH
960 970 980 990 1000
KPLDPETIAQ DIEETMNTAL NELRELERQS TVKHAPDVVL DTLEQVKNSP
1010 1020 1030 1040 1050
TPATSTESLS PLHNVALRGS EPQIRRSTSS SSETMSTFKP MVAPRMGVQL
1060 1070 1080
KPPALRPKPA VLPKTNPTMG PAAPSQGPTD KSCTM
Length:1,085
Mass (Da):124,100
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2809AF70E44AE167
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91Z69SRGP1_MOUSE
SLIT-ROBO Rho GTPase-activating pro...
Srgap1 Arhgap13
1,062Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7D9F7F7D9F7_MOUSE
SLIT-ROBO Rho GTPase-activating pro...
Srgap1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001074506.1, NM_001081037.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000081688; ENSMUSP00000080389; ENSMUSG00000020121

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117600

UCSC genome browser

More...
UCSCi
uc007hgb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001074506.1, NM_001081037.2

3D structure databases

SMRiD3YZW1
ModBaseiSearch...

Proteomic databases

MaxQBiD3YZW1
PeptideAtlasiD3YZW1
PRIDEiD3YZW1
ProteomicsDBi312364

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29129, 226 antibodies

Genome annotation databases

EnsembliENSMUST00000081688; ENSMUSP00000080389; ENSMUSG00000020121
GeneIDi117600
UCSCiuc007hgb.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57522
MGIiMGI:2152936, Srgap1

Phylogenomic databases

GeneTreeiENSGT00950000182824
HOGENOMiCLU_005715_0_0_1
OrthoDBi1245523at2759
PhylomeDBiD3YZW1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
117600, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Srgap1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020121, Expressed in cortical plate and 215 other tissues
GenevisibleiD3YZW1, MM

Family and domain databases

CDDicd07683, F-BAR_srGAP1, 1 hit
cd11955, SH3_srGAP1-3, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR001060, FCH_dom
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035648, srGAP1/2/3_SH3
IPR037451, srGAP1_F-BAR
PfamiView protein in Pfam
PF00611, FCH, 1 hit
PF00620, RhoGAP, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00055, FCH, 1 hit
SM00324, RhoGAP, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741, F_BAR, 1 hit
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YZW1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YZW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 2, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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