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Protein

Coiled-coil domain-containing protein 8 homolog

Gene

Ccdc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.By similarity

Miscellaneous

Despite its name, does not contain a coiled coil domain.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 8 homolog
Gene namesi
Name:Ccdc8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3612184 Ccdc8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158071 – 685Coiled-coil domain-containing protein 8 homologAdd BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineCombined sources1
Modified residuei146PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiD3YZV8
PaxDbiD3YZV8
PeptideAtlasiD3YZV8
PRIDEiD3YZV8

PTM databases

iPTMnetiD3YZV8
PhosphoSitePlusiD3YZV8

Expressioni

Gene expression databases

BgeeiENSMUSG00000041117 Expressed in 130 organ(s), highest expression level in dorsal pancreas
GenevisibleiD3YZV8 MM

Interactioni

Subunit structurei

Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts (via PxLPxI/L motif) with ANKRA2 (via ankyrin repeats); may link the 3M complex to histone deacetylases including HDAC4 and HDAC5.By similarity

Protein-protein interaction databases

BioGridi241620, 1 interactor
STRINGi10090.ENSMUSP00000092399

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi647 – 653PxLPxI/L motif; mediates interaction with ANKRA2By similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi298 – 552Ala-richAdd BLAST255

Domaini

The PxLPxI/L motif mediates interaction with ankyrin repeats of ANKRA2.By similarity

Phylogenomic databases

eggNOGiENOG410J8V3 Eukaryota
ENOG410Y3DP LUCA
GeneTreeiENSGT00440000038596
HOGENOMiHOG000111446
InParanoidiD3YZV8
KOiK17561
OrthoDBiEOG091G0BG9
PhylomeDBiD3YZV8
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026526 Coiled-coil_p8
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 3 hits
PTHR23095:SF2 PTHR23095:SF2, 3 hits
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequencei

Sequence statusi: Complete.

D3YZV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQIGEDVDY LLIPREVRLA GGVWRVISKP ATKEAEFRER LIQFLQEEGR
60 70 80 90 100
TLEDVARIIE KSTPHPPQPR KRTKELRVRR VPQMVTPPLR LVVGTYDSSN
110 120 130 140 150
GSDSELSDFD TSKVKGNRSS SGRTRKVRKM PVSYLGSKFL GSDVESEDDQ
160 170 180 190 200
ELVEAFLRRG EKPSAPPPRR RVNLPVPMFE NNLGPQPSKA DRWREYVSQV
210 220 230 240 250
SWGKLKQRVK GWAPRSGSEV GQTQQASTAA ERAGEMRHSQ ASSDDDSSRN
260 270 280 290 300
TGDRSDQMLG TRRWKPKIKW VSLRRCRKEQ VPPFAQGTGM PAEEHPEAAE
310 320 330 340 350
NQGAEAAANQ RAEPLASPRA EAAASPRAET AADPRVEAVA SPRAEAAASP
360 370 380 390 400
RAEAVADPRA EAAASPRAEA AASPRTEAAA SLRAEAVASP RAEAAASPRA
410 420 430 440 450
EAAADPRAEA AASPIAEAAA NQKAELVDSP RAETAADPRA EAAASPRAEA
460 470 480 490 500
VADPRVEAAA SPIAEAAANQ KAELVDSPRA ETAADPRAEA AASPRAEAAA
510 520 530 540 550
DPRAEVAASP RAEAAASPRA EAEASPRAEA AASPKAEAEA NLRVEAAAYL
560 570 580 590 600
RAGVPPDQRA EAIDSQRAEG PANQRTGATE NQRVEVLADQ RAGVLHDQRE
610 620 630 640 650
EAGPQGIQEA SAGSGSRAQK QVKTVRFQTP GRFSWFRMRR RVFWHTPRLP
660 670 680
TLPRRVPRAG EARSLRVLRA DIRADVEHRE QEEQL
Length:685
Mass (Da):73,938
Last modified:April 5, 2011 - v2
Checksum:i72CBA6C436127E02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148976 Genomic DNA No translation available.
CH466654 Genomic DNA Translation: EDL42062.1
CCDSiCCDS52044.1
RefSeqiNP_001095005.1, NM_001101535.1
UniGeneiMm.484826

Genome annotation databases

EnsembliENSMUST00000094805; ENSMUSP00000092399; ENSMUSG00000041117
GeneIDi434130
KEGGimmu:434130
UCSCiuc012fak.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148976 Genomic DNA No translation available.
CH466654 Genomic DNA Translation: EDL42062.1
CCDSiCCDS52044.1
RefSeqiNP_001095005.1, NM_001101535.1
UniGeneiMm.484826

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi241620, 1 interactor
STRINGi10090.ENSMUSP00000092399

PTM databases

iPTMnetiD3YZV8
PhosphoSitePlusiD3YZV8

Proteomic databases

MaxQBiD3YZV8
PaxDbiD3YZV8
PeptideAtlasiD3YZV8
PRIDEiD3YZV8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094805; ENSMUSP00000092399; ENSMUSG00000041117
GeneIDi434130
KEGGimmu:434130
UCSCiuc012fak.1 mouse

Organism-specific databases

CTDi83987
MGIiMGI:3612184 Ccdc8

Phylogenomic databases

eggNOGiENOG410J8V3 Eukaryota
ENOG410Y3DP LUCA
GeneTreeiENSGT00440000038596
HOGENOMiHOG000111446
InParanoidiD3YZV8
KOiK17561
OrthoDBiEOG091G0BG9
PhylomeDBiD3YZV8
TreeFamiTF335054

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Miscellaneous databases

PROiPR:D3YZV8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041117 Expressed in 130 organ(s), highest expression level in dorsal pancreas
GenevisibleiD3YZV8 MM

Family and domain databases

InterProiView protein in InterPro
IPR026526 Coiled-coil_p8
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 3 hits
PTHR23095:SF2 PTHR23095:SF2, 3 hits
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCDC8_MOUSE
AccessioniPrimary (citable) accession number: D3YZV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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