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Protein

Coiled-coil domain-containing protein 6

Gene

Ccdc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 6
Gene namesi
Name:Ccdc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1923801 Ccdc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004158082 – 469Coiled-coil domain-containing protein 6Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei242PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei277PhosphoserineBy similarity1
Modified residuei316PhosphoserineCombined sources1
Modified residuei342PhosphothreonineBy similarity1
Modified residuei356PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei380Omega-N-methylarginineCombined sources1
Modified residuei388PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiD3YZP9
MaxQBiD3YZP9
PaxDbiD3YZP9
PeptideAtlasiD3YZP9
PRIDEiD3YZP9

PTM databases

iPTMnetiD3YZP9
PhosphoSitePlusiD3YZP9

Expressioni

Gene expression databases

BgeeiENSMUSG00000048701 Expressed in 289 organ(s), highest expression level in embryo
ExpressionAtlasiD3YZP9 baseline and differential
GenevisibleiD3YZP9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218173, 1 interactor
IntActiD3YZP9, 1 interactor
STRINGi10090.ENSMUSP00000123374

Structurei

3D structure databases

ProteinModelPortaliD3YZP9
SMRiD3YZP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 1271Add BLAST29
Repeati128 – 1562Add BLAST29
Repeati157 – 1853Add BLAST29
Repeati186 – 1994; approximateAdd BLAST14
Repeati200 – 2285Add BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 2285 X 29 AA tandem repeatsAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 320Sequence analysisAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi435 – 444SH3-bindingSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi433 – 441Poly-Pro9

Domaini

The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.By similarity

Keywords - Domaini

Coiled coil, Repeat, SH3-binding

Phylogenomic databases

eggNOGiKOG2129 Eukaryota
ENOG410XR5H LUCA
GeneTreeiENSGT00390000013594
HOGENOMiHOG000091755
InParanoidiD3YZP9
KOiK09288
OMAiQNRCYAC
OrthoDBiEOG091G07PT
PhylomeDBiD3YZP9
TreeFamiTF321211

Family and domain databases

InterProiView protein in InterPro
IPR019152 DUF2046
PANTHERiPTHR15276 PTHR15276, 1 hit
PfamiView protein in Pfam
PF09755 DUF2046, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3YZP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSASESDT DAAGGGPAAM QSSCSATSGG SGGGGGGKSG GIVISPFRLE
60 70 80 90 100
ELTNRLASLQ QENKVLKIEL ETYKLKCKAL QEENRDLRKA SVTIQARAEQ
110 120 130 140 150
EEEFISNTLF KKIQALQKEK ETLAVNYEKE EEFLTNELSR KLMQLQHEKA
160 170 180 190 200
ELEQHLEQEQ EFQVNKLMKK IKKLENDTIS KQLTLEQLRR EKIDLENTLE
210 220 230 240 250
QEQEALVNRL WKRMDKLEAE KRILQEKLDQ PVSAPPSPRD ISMEIDSPEN
260 270 280 290 300
MMRHIRFLKN EVERLKKQLR AAQLQHSEKM AQYLEEERHM REENLRLQRK
310 320 330 340 350
LQREMERREA LCRQLSESES SLEMDDERYF NEMSAQGLRP RTVSSPIPYT
360 370 380 390 400
PSPSSSRPIS PGLSYASHTV GFTPPTSLTR AGMSYYNSPG LHVQHMGASH
410 420 430 440 450
GITRPSPRRS SSPDKFKRPT PPPSPNTQSP VQPPPPPPPP PMQPAVPSAA
460
PTQPAPTQPQ HPVHPSSQP
Length:469
Mass (Da):52,939
Last modified:April 20, 2010 - v1
Checksum:i708882EB2F131354
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SXB0F6SXB0_MOUSE
Coiled-coil domain-containing prote...
Ccdc6
137Annotation score:
F7B4D5F7B4D5_MOUSE
Coiled-coil domain-containing prote...
Ccdc6
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132435 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31982.1
CCDSiCCDS48591.1
RefSeqiNP_001104591.1, NM_001111121.1
UniGeneiMm.281741

Genome annotation databases

EnsembliENSMUST00000147545; ENSMUSP00000123374; ENSMUSG00000048701
GeneIDi76551
KEGGimmu:76551
UCSCiuc011xfv.1 mouse

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132435 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31982.1
CCDSiCCDS48591.1
RefSeqiNP_001104591.1, NM_001111121.1
UniGeneiMm.281741

3D structure databases

ProteinModelPortaliD3YZP9
SMRiD3YZP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218173, 1 interactor
IntActiD3YZP9, 1 interactor
STRINGi10090.ENSMUSP00000123374

PTM databases

iPTMnetiD3YZP9
PhosphoSitePlusiD3YZP9

Proteomic databases

EPDiD3YZP9
MaxQBiD3YZP9
PaxDbiD3YZP9
PeptideAtlasiD3YZP9
PRIDEiD3YZP9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000147545; ENSMUSP00000123374; ENSMUSG00000048701
GeneIDi76551
KEGGimmu:76551
UCSCiuc011xfv.1 mouse

Organism-specific databases

CTDi8030
MGIiMGI:1923801 Ccdc6

Phylogenomic databases

eggNOGiKOG2129 Eukaryota
ENOG410XR5H LUCA
GeneTreeiENSGT00390000013594
HOGENOMiHOG000091755
InParanoidiD3YZP9
KOiK09288
OMAiQNRCYAC
OrthoDBiEOG091G07PT
PhylomeDBiD3YZP9
TreeFamiTF321211

Miscellaneous databases

ChiTaRSiCcdc6 mouse
PROiPR:D3YZP9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048701 Expressed in 289 organ(s), highest expression level in embryo
ExpressionAtlasiD3YZP9 baseline and differential
GenevisibleiD3YZP9 MM

Family and domain databases

InterProiView protein in InterPro
IPR019152 DUF2046
PANTHERiPTHR15276 PTHR15276, 1 hit
PfamiView protein in Pfam
PF09755 DUF2046, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCDC6_MOUSE
AccessioniPrimary (citable) accession number: D3YZP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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