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Entry version 51 (08 May 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Family with sequence similarity 205, member A1

Gene

Fam205a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Family with sequence similarity 205, member A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam205a1Imported
Synonyms:Gm12429Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:3651059 Fam205a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 31HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
D3YZF6

PRoteomics IDEntifications database

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PRIDEi
D3YZF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000078721 Expressed in 11 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000103613

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 138DUF4599InterPro annotationAdd BLAST87
Domaini414 – 480FAM75InterPro annotationAdd BLAST67
Domaini468 – 604FAM75InterPro annotationAdd BLAST137

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITN3 Eukaryota
ENOG4111BIV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183043

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231609

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3YZF6

Database of Orthologous Groups

More...
OrthoDBi
270197at2759

TreeFam database of animal gene trees

More...
TreeFami
TF339420

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027970 DUF4599
IPR039509 SPATA31/FAM205

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15371 DUF4599, 1 hit
PF14650 FAM75, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3YZF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSTMCFLWD TECPLYVYFC IFIIVLIVWQ VCQNYQGLKC ENRRSCCRRH
60 70 80 90 100
QKVRQRAKDA ASRARGLSRE EDEKPCELLS IMKSQSWVPK QGNVRQLLCL
110 120 130 140 150
DPSCQICEAT TLEIRQLLQS EKSQISPALL GLPQSPACLE MPISSESFEW
160 170 180 190 200
NQDFYSRYST NSPVVPGNQT LTQLTEELTG SINADGAPLC WTDPLQVGQE
210 220 230 240 250
FHLADMPMAS ETLVSPGLEE PVVLMNEEDT VHSNLNYIQQ LQDHEALNSQ
260 270 280 290 300
VPFQTLTPQL TVTHPMAVSI VTDAPQPFLS PEVLRLLEIH VKKLMHFQRW
310 320 330 340 350
GLPRRVEESL KQFMPNPPVY LRPEHNQPVS FILNTSSQDC VHRFEGISPE
360 370 380 390 400
TWYSYMDGQP IQTFWVSEWS SGDQGQRLSC KPIPSLVEKP LLTPDYELLH
410 420 430 440 450
DLCLSPEGQV DGSQSNLQKK FTQLFCGLPS MHSESLGSTF LCTQGVSKNT
460 470 480 490 500
LKPPYKEPHF LKVSPPIPLP EAAPPPSSTS PNESLDEPQR AQIGGVPFLT
510 520 530 540 550
LSECKTLEWH LLQRQLQLQW GLSAVIARPP RVQSHTQYKH KPWNKAKPRE
560 570 580 590 600
TLKFFGPGKP FSAFTRELFF IPQHARKLLE FHLQKRLIHL RWGLPQRIQR
610 620 630 640 650
SINMLLSSTD PQSLPCGGSR LPNVSISQPG KPEAYGSGDT FLPTAGKGTT
660 670 680 690 700
PMPHLFAKAQ EMLKSHFDTK CEQIREGKVP ACVQSAWKGR IPGDLAAGTL
710 720 730 740 750
FPNIPQGQPL ELQAENNPDL HQEAVSWKPM DLDQEAQAFS GVFIEHCRRP
760 770 780 790 800
QALSEETIKK LETTLRHKYL AFLSGLQALY CMAPTKATSP TVDQSVITTM
810 820 830 840 850
PWSVKSPQKP LSQKSPLEAL CLSGLEPCTQ DDKETSANIA EEFQHGAQGH
860 870 880 890 900
GRTEKVPPER QPLLNRPYSL DTEIMERVSF YLKRKALDIK LGISLKESVF
910 920 930 940 950
QEPTATDLES ESVQEPLRSP RESTLLQGPP TLCHVPVAPD PDKVCLKQPA
960 970 980 990 1000
TAVQVVFQEQ NQPSSRAVPH RSARQGSQVH RNMMEAQVHY VQMGTGGEML
1010 1020 1030 1040 1050
NLGEPFSTES QSPGKSKSGY VPTVAGKRKI PGKPKVVGDL GEGDAGLGFS
1060 1070 1080 1090 1100
LVSLKTRQDG EQEKRLLHRQ LQGSSLQAQT FHLEGACPHS PQESPELQFA
1110 1120 1130 1140 1150
DPPPEVFMET DSEQDMEDSQ SKESIVPEPA RTAKAPQPML SRASQGLPFP
1160 1170 1180 1190 1200
RSPTQRKPSQ GQPGPGHVPP GHATPASPYT RPSRLPEAGL KNKMKLFFHS
1210 1220 1230 1240 1250
IKLKMKSKAH TEPSTVSTPG KVAKTSKENI DRGLPQAKSP TKKTKPEDFR
1260 1270 1280 1290 1300
GPKAQFSSSE KSVVGPCLTP SYILDSKFWP RPRRVGSVSV LGHSYHCPRH
1310
CPRLAYANQQ RNPP
Length:1,314
Mass (Da):146,615
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5946FBF73A9097E4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL772334 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001264096.1, NM_001277167.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000107979; ENSMUSP00000103613; ENSMUSG00000078721

Database of genes from NCBI RefSeq genomes

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GeneIDi
433698

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:433698

UCSC genome browser

More...
UCSCi
uc029uty.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772334 Genomic DNA No translation available.
RefSeqiNP_001264096.1, NM_001277167.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103613

Proteomic databases

PaxDbiD3YZF6
PRIDEiD3YZF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107979; ENSMUSP00000103613; ENSMUSG00000078721
GeneIDi433698
KEGGimmu:433698
UCSCiuc029uty.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
433698
MGIiMGI:3651059 Fam205a1

Phylogenomic databases

eggNOGiENOG410ITN3 Eukaryota
ENOG4111BIV LUCA
GeneTreeiENSGT00950000183043
HOGENOMiHOG000231609
InParanoidiD3YZF6
OrthoDBi270197at2759
TreeFamiTF339420

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000078721 Expressed in 11 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR027970 DUF4599
IPR039509 SPATA31/FAM205
PfamiView protein in Pfam
PF15371 DUF4599, 1 hit
PF14650 FAM75, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YZF6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YZF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 8, 2019
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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