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Protein

WD repeat-containing protein 72

Gene

Wdr72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in formation of tooth enamel (PubMed:25008349, PubMed:26247047). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins (PubMed:25008349, PubMed:26247047). May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane (PubMed:26247047).2 Publications

GO - Biological processi

  • enamel mineralization Source: MGI

Keywordsi

Biological processBiomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 72By similarity
Gene namesi
Name:Wdr72Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3583957 Wdr72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Disruption phenotypei

Viable with no gross morpholgical defects (PubMed:25008349, PubMed:26247047). At 6-7 weeks of age teeth have an opaque, chalky appearance, with reduced enamel thickness at occlusal surfaces (PubMed:25008349, PubMed:26247047). Body weight is reduced, probably due to problems with chewing hard foods (PubMed:25008349). Enamel formation is abnormal from the maturation stage onwards with significantly reduced mineral density and retention of proteinaceous material in the enamel matrix (PubMed:25008349, PubMed:26247047). Tooth enamel hardness is ten times lower than wild type (PubMed:26247047). Attachment of ameloblasts to the enamel layer may be weakened (PubMed:26247047). The calcium transporter SLC24A4 fails to localize to the distal ameloblast membrane (PubMed:26247047). In maturation stage ameloblasts expression levels of amelogenin appear to be reduced, although abnormally high amelogenin levels are found in the extracellular enamel matrix (PubMed:25008349, PubMed:26247047).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004381881 – 1114WD repeat-containing protein 72Add BLAST1114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1093PhosphoserineCombined sources1
Modified residuei1095PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiD3YYM4
PaxDbiD3YYM4
PRIDEiD3YYM4

PTM databases

iPTMnetiD3YYM4
PhosphoSitePlusiD3YYM4

Expressioni

Tissue specificityi

Expressed in maturation stage ameloblasts (at protein level) (PubMed:19853237, PubMed:25008349).

Gene expression databases

BgeeiENSMUSG00000044976 Expressed in 17 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiD3YYM4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057320

Structurei

3D structure databases

ProteinModelPortaliD3YYM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 54WD 1Sequence analysisAdd BLAST40
Repeati60 – 102WD 2Sequence analysisAdd BLAST43
Repeati160 – 197WD 3Sequence analysisAdd BLAST38
Repeati327 – 373WD 4Sequence analysisAdd BLAST47
Repeati413 – 452WD 5Sequence analysisAdd BLAST40
Repeati470 – 515WD 6Sequence analysisAdd BLAST46
Repeati566 – 605WD 7Sequence analysisAdd BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410KDHE Eukaryota
ENOG411264G LUCA
GeneTreeiENSGT00520000055590
HOGENOMiHOG000168573
InParanoidiD3YYM4
OMAiWGVDKEL
OrthoDBiEOG091G01B8
PhylomeDBiD3YYM4
TreeFamiTF313196

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011044 Quino_amine_DH_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50969 SSF50969, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3YYM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGALQAVAL WGRKAPPHSI TAIMITDDQQ TIVTGSQEGQ LCLWSLSPEL
60 70 80 90 100
KISAKELLFG HSASVTCLAR ARDFSKQPYV VSAAENGEMC MWNVSSGQCV
110 120 130 140 150
EKTSLPYRHT AICYYHCSFR MTGEGWLLCC GEYQDVLVLD AGTLAVLHTF
160 170 180 190 200
TSLQSPDWMK CMCIVHSVRI QEDSLLVVSI TGELKVWDLS SSINSIQEKQ
210 220 230 240 250
DVHEKESKFL DSFNCQTIRF CPYTERLLLV VFSKCWKIYD YCDFSLLWTE
260 270 280 290 300
VSRDGQFFAG GEVLAAHRIL VWTEDGHSYI YQLLNRWAQM GATLRTFSGL
310 320 330 340 350
SKCVCPADGG VLKGTVYPHL LCSTSVEENK SLHFVMGYMN ERKEPFYKVL
360 370 380 390 400
FSGEVSGRIT LWHIPDVPIS KFDGSPREIP ITTTWTLQDN FDKHQMVSQS
410 420 430 440 450
ITDHFSGSRD EVGMTATITS SEYIPNLDKL ICGCEDGTIF ITKALNAAKA
460 470 480 490 500
GLLEGDSLLK DSPCHTLLRG HHQSVTSLLY PHNLASKLDQ SWMVSGDRGS
510 520 530 540 550
YVILWDIFTE EILHTFFLEA GPVTRLLMSP ENLKRSDGQI LCCVCGDHSV
560 570 580 590 600
ALLHLEGRRC LLRARKHLFP VRMIRWHPVE NFLIVGCTDD SVYIWEIETG
610 620 630 640 650
TLERHETGER ARIILNCGDD AQLIRSEPTL SVASETHKHK SIEQKSSNSH
660 670 680 690 700
QPGPVPCPSV QLESSCKVAD ASSVPRPFNV LPVKTKWSHI GFHVLLFDLE
710 720 730 740 750
NLVELLLPTP LSDVDPSGSF YGGDILRRAK STVEKKTLTI RRNKASCSSL
760 770 780 790 800
QTEAQAKPSG DSLVLGDSTS KFSEENNGIK RQKKMKSSKK AHPKPPRKVD
810 820 830 840 850
ASLTIDMAKL FLSCILPWGV DKDLDSLCTR HLSILKLQGP VSLGLASNED
860 870 880 890 900
LFSLMLPGWD ACSTEMKEYS GVNLCSRKVL DLSSKYTATL LHQTGIPRGL
910 920 930 940 950
ESHCDSVQQS DAIVYLLSRL FLVNKLVNMP LDLACEIDRP FKMETVHSKA
960 970 980 990 1000
RFPGSDILNI SSFYGHPKNG GNECRAPEAD LSLLKLISCW RDQSVQVTEA
1010 1020 1030 1040 1050
IQAVLLAEVQ QHMKSLRNTP VSSQPDPVAE HSICERMQIS AKMEWTEELE
1060 1070 1080 1090 1100
LQYVGKSSPL KTSVSPVKHG NDLNSANFQD TEDILDRCVL EESESAGQPR
1110
HRPWIAKVCS CRMC
Length:1,114
Mass (Da):124,410
Last modified:April 20, 2010 - v1
Checksum:i209D3BF22B75E72C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SR77A0A1L1SR77_MOUSE
WD repeat-containing protein 72
Wdr72
1,102Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108944 Genomic DNA No translation available.
AC111087 Genomic DNA No translation available.
CCDSiCCDS23338.2
RefSeqiNP_001028672.2, NM_001033500.3
XP_006511342.1, XM_006511279.2
UniGeneiMm.335289

Genome annotation databases

EnsembliENSMUST00000055879; ENSMUSP00000057320; ENSMUSG00000044976
GeneIDi546144
KEGGimmu:546144
UCSCiuc009qre.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108944 Genomic DNA No translation available.
AC111087 Genomic DNA No translation available.
CCDSiCCDS23338.2
RefSeqiNP_001028672.2, NM_001033500.3
XP_006511342.1, XM_006511279.2
UniGeneiMm.335289

3D structure databases

ProteinModelPortaliD3YYM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057320

PTM databases

iPTMnetiD3YYM4
PhosphoSitePlusiD3YYM4

Proteomic databases

MaxQBiD3YYM4
PaxDbiD3YYM4
PRIDEiD3YYM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055879; ENSMUSP00000057320; ENSMUSG00000044976
GeneIDi546144
KEGGimmu:546144
UCSCiuc009qre.1 mouse

Organism-specific databases

CTDi256764
MGIiMGI:3583957 Wdr72

Phylogenomic databases

eggNOGiENOG410KDHE Eukaryota
ENOG411264G LUCA
GeneTreeiENSGT00520000055590
HOGENOMiHOG000168573
InParanoidiD3YYM4
OMAiWGVDKEL
OrthoDBiEOG091G01B8
PhylomeDBiD3YYM4
TreeFamiTF313196

Miscellaneous databases

PROiPR:D3YYM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044976 Expressed in 17 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiD3YYM4 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011044 Quino_amine_DH_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50969 SSF50969, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiWDR72_MOUSE
AccessioniPrimary (citable) accession number: D3YYM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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