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Protein

Probable E3 ubiquitin-protein ligase RNF217

Gene

Rnf217

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi236Zinc 1PROSITE-ProRule annotation1
Metal bindingi239Zinc 1PROSITE-ProRule annotation1
Metal bindingi256Zinc 1PROSITE-ProRule annotation1
Metal bindingi259Zinc 1PROSITE-ProRule annotation1
Metal bindingi356Zinc 2PROSITE-ProRule annotation1
Metal bindingi359Zinc 2PROSITE-ProRule annotation1
Metal bindingi364Zinc 2; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi369Zinc 2PROSITE-ProRule annotation1
Metal bindingi396Zinc 3PROSITE-ProRule annotation1
Metal bindingi399Zinc 3PROSITE-ProRule annotation1
Active sitei409PROSITE-ProRule annotation1
Metal bindingi414Zinc 3PROSITE-ProRule annotation1
Metal bindingi417Zinc 3PROSITE-ProRule annotation1
Metal bindingi422Zinc 4PROSITE-ProRule annotation1
Metal bindingi425Zinc 4PROSITE-ProRule annotation1
Metal bindingi438Zinc 4; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi447Zinc 4PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri236 – 282RING-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri301 – 369IBR-typePROSITE-ProRule annotationAdd BLAST69
Zinc fingeri396 – 425RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase RNF217 (EC:2.3.2.31By similarity)
Alternative name(s):
IBR domain-containing protein 1
RING finger protein 217
Gene namesi
Name:Rnf217
Synonyms:Ibrdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3610311 Rnf217

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158211 – 515Probable E3 ubiquitin-protein ligase RNF217Add BLAST515

Proteomic databases

PaxDbiD3YYI7
PRIDEiD3YYI7

PTM databases

iPTMnetiD3YYI7
PhosphoSitePlusiD3YYI7

Expressioni

Gene expression databases

BgeeiENSMUSG00000063760 Expressed in 239 organ(s), highest expression level in urinary bladder
GenevisibleiD3YYI7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080650

Structurei

3D structure databases

ProteinModelPortaliD3YYI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 451TRIAD supradomainPROSITE-ProRule annotationAdd BLAST220

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 55Poly-Gly5
Compositional biasi105 – 217Pro-richAdd BLAST113

Domaini

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

Sequence similaritiesi

Belongs to the RBR family. RNF217 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri236 – 282RING-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri301 – 369IBR-typePROSITE-ProRule annotationAdd BLAST69
Zinc fingeri396 – 425RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1815 Eukaryota
ENOG410XP9Y LUCA
GeneTreeiENSGT00730000111285
HOGENOMiHOG000008112
InParanoidiD3YYI7
KOiK11977
OMAiVYCVEND
OrthoDBiEOG091G0R5I
PhylomeDBiD3YYI7
TreeFamiTF330860

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR11685 PTHR11685, 1 hit
PfamiView protein in Pfam
PF01485 IBR, 2 hits
SMARTiView protein in SMART
SM00647 IBR, 2 hits
PROSITEiView protein in PROSITE
PS51873 TRIAD, 1 hit

Sequencei

Sequence statusi: Complete.

D3YYI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEEQSTVSG SGGARASGGG SAGQPESPRP RGDRVRTAGP RAAASSSRPN
60 70 80 90 100
GGGGGRDPGC VDASVQEPAS NRAPAGQPAR LPLSGPLDPQ SLELQLEREA
110 120 130 140 150
EGAGPREAPP GQQPPDGLLL DVLAQRHPPP AKPQVLCSVY CVESDLPEAP
160 170 180 190 200
SAESPSPSES PPQAPLGPIP ASPPPSFPSS PLSLPADPLS PDGGSIELEF
210 220 230 240 250
YLAPEPFSVP GLLGAPPYSG LGGVGDPYAP LMVLMCRVCL EDKPIKPLPC
260 270 280 290 300
CKKAVCEECL KIYLSSQVQL GQVEIKCPVT ECFEFLEETT VVYNLTHEDS
310 320 330 340 350
IKYKYFLELG RIDSSTKPCP QCKHFTTFKK KGHIPTPSRS ESRYKIQCPT
360 370 380 390 400
CQLIWCFKCH SPWHEGVNCK EYKKGDKLLR HWASEIEHGQ RNAQKCPKCK
410 420 430 440 450
IHIQRTEGCD HMTCSQCNTN FCYRCGERYR QLRFFGDHTS NLSIFGCKYR
460 470 480 490 500
YLPERPHLRR LVRGSVCAGK LFIAPLILVL GLALGAIAVV IGLFVFPIYC
510
LCKKQRKRSR TGMHW
Length:515
Mass (Da):56,036
Last modified:April 5, 2011 - v2
Checksum:i718AF99658F9F55D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116557 Genomic DNA No translation available.
CCDSiCCDS48531.1
RefSeqiNP_001139821.1, NM_001146349.1
UniGeneiMm.295212

Genome annotation databases

EnsembliENSMUST00000081989; ENSMUSP00000080650; ENSMUSG00000063760
GeneIDi268291
KEGGimmu:268291
UCSCiuc007etu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116557 Genomic DNA No translation available.
CCDSiCCDS48531.1
RefSeqiNP_001139821.1, NM_001146349.1
UniGeneiMm.295212

3D structure databases

ProteinModelPortaliD3YYI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080650

PTM databases

iPTMnetiD3YYI7
PhosphoSitePlusiD3YYI7

Proteomic databases

PaxDbiD3YYI7
PRIDEiD3YYI7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081989; ENSMUSP00000080650; ENSMUSG00000063760
GeneIDi268291
KEGGimmu:268291
UCSCiuc007etu.2 mouse

Organism-specific databases

CTDi154214
MGIiMGI:3610311 Rnf217

Phylogenomic databases

eggNOGiKOG1815 Eukaryota
ENOG410XP9Y LUCA
GeneTreeiENSGT00730000111285
HOGENOMiHOG000008112
InParanoidiD3YYI7
KOiK11977
OMAiVYCVEND
OrthoDBiEOG091G0R5I
PhylomeDBiD3YYI7
TreeFamiTF330860

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:D3YYI7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063760 Expressed in 239 organ(s), highest expression level in urinary bladder
GenevisibleiD3YYI7 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR11685 PTHR11685, 1 hit
PfamiView protein in Pfam
PF01485 IBR, 2 hits
SMARTiView protein in SMART
SM00647 IBR, 2 hits
PROSITEiView protein in PROSITE
PS51873 TRIAD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN217_MOUSE
AccessioniPrimary (citable) accession number: D3YYI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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