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Protein

Histone-lysine N-methyltransferase

Gene

Setdb1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Setdb1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1934229 Setdb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000015697 Expressed in 291 organ(s), highest expression level in secondary oocyte

Interactioni

Protein-protein interaction databases

IntActiD3YYC3, 8 interactors
D3YYC3, 8 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini612 – 683MBDInterPro annotationAdd BLAST72
Domaini745 – 818Pre-SETInterPro annotationAdd BLAST74
Domaini821 – 1283SETInterPro annotationAdd BLAST463
Domaini1292 – 1308Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 64Sequence analysisAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1141 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000154292
KOiK11421
OrthoDBiEOG091G014F
TreeFamiTF106411

Family and domain databases

InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR025796 Hist-Lys_N-MeTrfase_SETDB1
IPR001739 Methyl_CpG_DNA-bd
IPR003616 Post-SET_dom
IPR007728 Pre-SET_dom
IPR001214 SET_dom
IPR002999 Tudor
PfamiView protein in Pfam
PF01429 MBD, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00391 MBD, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982 MBD, 1 hit
PS50868 POST_SET, 1 hit
PS50867 PRE_SET, 1 hit
PS51573 SAM_MT43_SUVAR39_1, 1 hit
PS50280 SET, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3YYC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK
60 70 80 90 100
MDCIQQRKKQ LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY
110 120 130 140 150
SKLGLQYHDS SSEDEASRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLGQVSG ELSKDGDLIV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSSASAME KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT GTGIQFKPME
460 470 480 490 500
PLQPIAPPAP LPIPPLSPQA ADTESLESQL AQSRKQVAKK STSFRPGSVG
510 520 530 540 550
SGHSSPTSST LSENVSAGKL GINQTYRSPL ASVTSTPASA APPVPPVPPG
560 570 580 590 600
PPTPPGPPAP PGPLAPPAFH GMLERAPAEP SYRAPMEKLF YLPHVCSYTC
610 620 630 640 650
LSRIRPMRNE QYRGKNPLLV PLLYDFRRMT ARRRVNRKMG FHVIYKTPCG
660 670 680 690 700
LCLRTMQEIE RYLFETGCDF LFLEMFCLDP YVLVDRKFQP FKPFYYILDI
710 720 730 740 750
TYGKEDVPLS CVNEIDTTPP PQVAYSKERI PGKGVFINTG PEFLVGCDCK
760 770 780 790 800
DGCRDKSKCA CHQLTIQATA CTPGGQVNPN SGYQYKRLEE CLPTGVYECN
810 820 830 840 850
KRCNCDPNMC TNRLVQHGLQ VRLQLFKTQN KGWGIRCLDD IAKGSFVCIY
860 870 880 890 900
AGKILTDDFA DKEGLEMGDE YFANLDHIES VENFKEGYES DVPTSSDSSG
910 920 930 940 950
VDMKDQEDGN SGSEDPEESN DDSSDDNFCK DEDFSTSSVW RSYATRRQTR
960 970 980 990 1000
GQKENELSEM TSKDSRPPDL GPPHVPIPSS VSVGGCNPPS SEETPKNKVA
1010 1020 1030 1040 1050
SWLSCNSVSE GGFADSDSRS SFKTSEGGDG RAGGGRGEAE RASTSGLSFK
1060 1070 1080 1090 1100
DEGDNKQPKK EDPENRNKMP VVTEGSQNHG HNPPMKSEGL RRSASKMSVL
1110 1120 1130 1140 1150
QSQRVVTSTQ SNPDDILTLS SSTESEGESG TSRKPTAGHT SATAVDSDDI
1160 1170 1180 1190 1200
QTISSGSDGD DFEDKKNLSG PTKRQVAVKS TRGFALKSTH GIAIKSTNMA
1210 1220 1230 1240 1250
SVDKGESAPV RKNTRQFYDG EESCYIIDAK LEGNLGRYLN HSCSPNLFVQ
1260 1270 1280 1290 1300
NVFVDTHDLR FPWVAFFASK RIRAGTELTW DYNYEVGSVE GKELLCCCGA

IECRGRLL
Length:1,308
Mass (Da):144,640
Last modified:April 20, 2010 - v1
Checksum:iB3D9AD6F61298E14
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O88974SETB1_MOUSE
Histone-lysine N-methyltransferase ...
Setdb1 Eset, Kiaa0067
1,307Annotation score:
G5E8N3G5E8N3_MOUSE
Histone-lysine N-methyltransferase
Setdb1 mCG_16729
1,307Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092202 Genomic DNA No translation available.
RefSeqiNP_001157113.1, NM_001163641.1
NP_061365.3, NM_018877.3
UniGeneiMm.490259

Genome annotation databases

EnsembliENSMUST00000015841; ENSMUSP00000015841; ENSMUSG00000015697
ENSMUST00000107170; ENSMUSP00000102788; ENSMUSG00000015697
GeneIDi84505
KEGGimmu:84505
UCSCiuc008qjl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092202 Genomic DNA No translation available.
RefSeqiNP_001157113.1, NM_001163641.1
NP_061365.3, NM_018877.3
UniGeneiMm.490259

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3YYC3, 8 interactors
D3YYC3, 8 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015841; ENSMUSP00000015841; ENSMUSG00000015697
ENSMUST00000107170; ENSMUSP00000102788; ENSMUSG00000015697
GeneIDi84505
KEGGimmu:84505
UCSCiuc008qjl.2 mouse

Organism-specific databases

CTDi9869
MGIiMGI:1934229 Setdb1

Phylogenomic databases

eggNOGiKOG1141 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000154292
KOiK11421
OrthoDBiEOG091G014F
TreeFamiTF106411

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines

Miscellaneous databases

ChiTaRSiSetdb1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015697 Expressed in 291 organ(s), highest expression level in secondary oocyte

Family and domain databases

InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR025796 Hist-Lys_N-MeTrfase_SETDB1
IPR001739 Methyl_CpG_DNA-bd
IPR003616 Post-SET_dom
IPR007728 Pre-SET_dom
IPR001214 SET_dom
IPR002999 Tudor
PfamiView protein in Pfam
PF01429 MBD, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00391 MBD, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982 MBD, 1 hit
PS50868 POST_SET, 1 hit
PS50867 PRE_SET, 1 hit
PS51573 SAM_MT43_SUVAR39_1, 1 hit
PS50280 SET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3YYC3_MOUSE
AccessioniPrimary (citable) accession number: D3YYC3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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