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Entry version 89 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

RIMS-binding protein 2

Gene

Rimbp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RIMS-binding protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rimbp2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443235, Rimbp2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000029420

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3YXR8

PRoteomics IDEntifications database

More...
PRIDEi
D3YXR8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
341129

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D3YXR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029420, Expressed in visual cortex and 138 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YXR8, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YXR8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 255SH3InterPro annotationAdd BLAST68
Domaini510 – 611Fibronectin type-IIIInterPro annotationAdd BLAST102
Domaini875 – 943SH3InterPro annotationAdd BLAST69
Domaini979 – 1046SH3InterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni604 – 687DisorderedSequence analysisAdd BLAST84
Regioni720 – 807DisorderedSequence analysisAdd BLAST88
Regioni1051 – 1079DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 81Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi605 – 621Pro residuesSequence analysisAdd BLAST17
Compositional biasi626 – 644Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi732 – 747Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi757 – 777Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1065 – 1079Basic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIMBP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183203

Database of Orthologous Groups

More...
OrthoDBi
102427at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3YXR8

TreeFam database of animal gene trees

More...
TreeFami
TF316230

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 3 hits
cd12012, SH3_RIM-BP_2, 1 hit
cd12013, SH3_RIM-BP_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035519, RIM-BP2
IPR035753, RIM-BP_SH3_2
IPR035755, RIM-BP_SH3_3
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR14234, PTHR14234, 2 hits
PTHR14234:SF18, PTHR14234:SF18, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07653, SH3_2, 1 hit
PF14604, SH3_9, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 1 hit
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

D3YXR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREAAERRQQ LELEHEQALA FLNAKQQEIQ LLQQAQVEAK KEHEGAVQLL
60 70 80 90 100
ENTLDCMQSK VRELEEKCRV QSEQFNLLSR DLEKFRQHTG SIDLLGSSSV
110 120 130 140 150
ALLDVPLAPG KPFPQYMNGL ATSIHKGHEG PTGHYSVIGD YIPLSGDKLE
160 170 180 190 200
SPCVKPSFLL RSSSPRCRFE SEMDNDRNSN NSKQSSSGKV HLCVARYSYN
210 220 230 240 250
PFDGPNENPE AELPLTAGKY LYVYGDMDED GFYEGELLDG QRGLVPSNFV
260 270 280 290 300
DFIQDNESRL AGTLGSEQDQ NFLNHSGISL ERDSILHLHS PTQVDSGITD
310 320 330 340 350
NGGGTLDVNI DDIGEDTVPY PRKITLIKQL AKSVIVGWEP PAVPPGWGTV
360 370 380 390 400
SSYNVLVDKE TRMSLALGRR TKALIEKLNT AACTYRISVQ CVTSRGNSDE
410 420 430 440 450
LQCTLLVGKD VVVAPSQLRV DNITQISAQL SWLPTNSNYS HIIFLNEEEL
460 470 480 490 500
DIVKAARYKY QFFNLRPNMA YKVKVLAQPH QMPWQLPLEQ REKKEACVEF
510 520 530 540 550
STLPAGPPAP PQDVTVHAGA TAASVQVSWK PPALTPTGLS NGANVTGYGV
560 570 580 590 600
YAKGQRVAEV IAPTADGTAV ELIRLRSLEA KAVSVRTLSV QGESMDSALA
610 620 630 640 650
AIPPDLLVPP APHPRTAPPP KPLASDMDTK DQHLGPHVKV DESWEQSRSP
660 670 680 690 700
GPAHGHMLEP PDMHSAGPGR RSPSPSRILP QPQGAPVSTT VAKAMAREAA
710 720 730 740 750
QRVAESNRLE KRSLFLEQSS AGQYTNSDEE DGYASPEVKR RGTSVDDFLK
760 770 780 790 800
GSELGKQPHC CHGDEYHTES SRGSDLSDIM EEDEEELYSE MQLEDGGRRR
810 820 830 840 850
PSGTSHNALK ILGNSTLMGR ADRMEHVSRR YSHSGGGSHR HRPAMAPSID
860 870 880 890 900
EYTGRDHLSP DFYDESETDP GAEELPARIF VALFDYDPLT MSPNPDAAEE
910 920 930 940 950
ELPFKEGQII KVYGDKDADG FYRGETCARL GLIPCNMVSE IHADDEEMMD
960 970 980 990 1000
QLLRQGFLPL NTPVEKIERS RRSGRGHSVP TRRMVALYDY DPRESSPNVD
1010 1020 1030 1040 1050
VEAELPFCTG DIITVFGEID EDGFYYGELN GQKGLVPSNF LEEVPDDVEV
1060 1070
HLSDAPPHYS HDPPMRSKAK RKKSVHFTP
Length:1,079
Mass (Da):119,148
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i560826C5504B5F98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80U40RIMB2_MOUSE
RIMS-binding protein 2
Rimbp2 Kiaa0318, Rbp2
1,072Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFB0A0A0G2JFB0_MOUSE
RIMS-binding protein 2
Rimbp2
1,071Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGW5A0A0G2JGW5_MOUSE
RIMS-binding protein 2
Rimbp2
1,004Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BDA2A0A571BDA2_MOUSE
RIMS-binding protein 2
Rimbp2
1,291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPV6A0A5F8MPV6_MOUSE
RIMS-binding protein 2
Rimbp2
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEC0A0A0G2JEC0_MOUSE
RIMS-binding protein 2
Rimbp2
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001074857.1, NM_001081388.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111346; ENSMUSP00000106978; ENSMUSG00000029420
ENSMUST00000198941; ENSMUSP00000142455; ENSMUSG00000029420

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231760

UCSC genome browser

More...
UCSCi
uc008zsl.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001074857.1, NM_001081388.2

3D structure databases

SMRiD3YXR8
ModBaseiSearch...

PTM databases

SwissPalmiD3YXR8

Proteomic databases

PeptideAtlasiD3YXR8
PRIDEiD3YXR8
ProteomicsDBi341129

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
65349, 44 antibodies

The DNASU plasmid repository

More...
DNASUi
231760

Genome annotation databases

EnsembliENSMUST00000111346; ENSMUSP00000106978; ENSMUSG00000029420
ENSMUST00000198941; ENSMUSP00000142455; ENSMUSG00000029420
GeneIDi231760
UCSCiuc008zsl.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23504
MGIiMGI:2443235, Rimbp2
VEuPathDBiHostDB:ENSMUSG00000029420

Phylogenomic databases

GeneTreeiENSGT00950000183203
OrthoDBi102427at2759
PhylomeDBiD3YXR8
TreeFamiTF316230

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
231760, 2 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rimbp2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029420, Expressed in visual cortex and 138 other tissues
GenevisibleiD3YXR8, MM

Family and domain databases

CDDicd00063, FN3, 3 hits
cd12012, SH3_RIM-BP_2, 1 hit
cd12013, SH3_RIM-BP_3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035519, RIM-BP2
IPR035753, RIM-BP_SH3_2
IPR035755, RIM-BP_SH3_3
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR14234, PTHR14234, 2 hits
PTHR14234:SF18, PTHR14234:SF18, 2 hits
PfamiView protein in Pfam
PF07653, SH3_2, 1 hit
PF14604, SH3_9, 2 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00326, SH3, 3 hits
SUPFAMiSSF49265, SSF49265, 2 hits
SSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 1 hit
PS50002, SH3, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YXR8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YXR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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