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Entry version 93 (02 Dec 2020)
Sequence version 2 (12 Aug 2020)
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Protein

Diacylglycerol kinase eta

Gene

Dgkh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:27643686). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity).By similarityCurated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri172 – 222Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri244 – 295Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00230

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase etaCurated (EC:2.7.1.1071 Publication)
Short name:
DAG kinase eta
Alternative name(s):
Diglyceride kinase eta
Short name:
DGK-eta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DgkhImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444188, Dgkh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004506651 – 1211Diacylglycerol kinase etaAdd BLAST1211

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation does not inhibit catalytic activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
D3YXJ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3YXJ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3YXJ0

PeptideAtlas

More...
PeptideAtlasi
A0A0B5JC35

PRoteomics IDEntifications database

More...
PRIDEi
D3YXJ0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3YXJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3YXJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:27643686). Detected in the granulosa cells of the primary and secondary follicles (PubMed:25613821). Expressed in mature follicles and corpus lutea (PubMed:25613821). Expressed in the oviductal epithelium (PubMed:25613821). In the uterus, strongly expressed in the luminal epithelium (PubMed:25613821). Detected in the uterine glands (PubMed:25613821).2 Publications
Detected in ovary and uterus (at protein level).1 Publication
Specifically expressed in testis (PubMed:25613821, PubMed:27643686). Detected in the inner area of the testis (PubMed:25613821). Strongly expressed in the secondary spermatocytes and the round spermatids and weakly detected in the primary spermatocytes (PubMed:25613821).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034731, Expressed in dorsal root ganglion and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3YXJ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YXJ0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAF1 and BRAF.

By similarity

Homooligomers. Heterooligomers. Oligomerization through the SAM domain inhibits the diacylglycerol kinase activity. Heterooligomerizes with SAM domain-containing isoforms of DGKD.

By similarity

Does not form homooligomers.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000074290

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
D3YXJ0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 155PHPROSITE-ProRule annotationAdd BLAST94
Domaini325 – 460DAGKcPROSITE-ProRule annotationAdd BLAST136
Domaini1143 – 1206SAMPROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAM domain mediates homooligomerization.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 222Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri244 – 295Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1170, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001799_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3YXJ0

Database of Orthologous Groups

More...
OrthoDBi
43384at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3YXJ0

TreeFam database of animal gene trees

More...
TreeFami
TF313104

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
2.30.29.30, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001660, SAM
IPR013761, SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF00169, PH, 1 hit
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00233, PH, 1 hit
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111331, SSF111331, 1 hit
SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50146, DAGK, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: D3YXJ0-1) [UniParc]FASTAAdd to basket
Also known as: DAG kinase eta-21 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAGSQHHP QGVAGGAVAG ASAVSPTAAG PGEDSSDSEA EQEGPQKLIR
60 70 80 90 100
KVSTSGQMRT KTSIKEGQLL KQTSSFQRWK KRYFKLRGRT LYYAKDSKSL
110 120 130 140 150
IFDEVDLSDA SVAEASTKNA NNSFTIITPF RRLMLCAENR KEMEVWISSL
160 170 180 190 200
KSVQSREPYE VAQFNVEHFS GMHNWYACSH ARPTFCNVCR ESLSGVTSHG
210 220 230 240 250
LSCEVCKFKA HKRCAVRATN NCKWTTLASI GKDIIEDEDG VAMPHQWLEG
260 270 280 290 300
NLPVSAKCAV CDKTCGSVLR LQDWKCLWCK TMVHTACKDV YHPVCPLGQC
310 320 330 340 350
KVSIIPPIAL NSTDSDGFCR ATFSFCVSPL LVFVNSKSGD NQGVKFLRRF
360 370 380 390 400
KQLLNPAQVF DLMNGGPYLG LRLFQKFDNF RILVCGGDGS VGWVLSEIDK
410 420 430 440 450
LNLHKQCQLG VLPLGTGNDL ARVLGWGGSY DDDTQLPQIL EKLERASTKM
460 470 480 490 500
LDRWSIMTYE LKLPAKSSLL PEPVAATEEF YMTIYEDSVA NHLTKIVNSD
510 520 530 540 550
EHAVVISSAK ILCETVKDFV AKVEKAQDRT LENTVVAEAV ASKCSVLNEK
560 570 580 590 600
LEQLLQALHA DSQASRVPPG IGPAIPEEDT VESASDESLG ESKDQLVNDI
610 620 630 640 650
GKPSSQKAVK PREIMLRANS LKKAVRQVIE EAEKVMDEPA VQPSEPVSPS
660 670 680 690 700
CDYDTETDEA KEDDAKESLS AKTTSQSPDA QASCGHPQTD SVAGPAMATT
710 720 730 740 750
KENLPVLNTR IICPGLRAGL AASIAGSSII NKMLLANIDP FGATPFIDPD
760 770 780 790 800
LDSLDGYSEK CVMNNYFGIG LDAKISLEFN NKREEHPEKC RSRTKNLMWY
810 820 830 840 850
GVLGTRELLQ RSYKNLEQRV QLECDGQYIP LPSLQGIAVL NIPSYAGGTN
860 870 880 890 900
FWGGTKEDDI FAAPSFDDKI LEVVAVFDSV QMAVSRVIKL QHHRIAQCRT
910 920 930 940 950
VKITIFGDEG VPVQVDGEAW VQPPGIIKIV HKNRAQMLTR DRAFESTLKS
960 970 980 990 1000
WEDKQKCDSG KPVLRTNLYI HPAPDLATEE VSQMRLCSQA AEELITRICD
1010 1020 1030 1040 1050
AATIHCLLEQ ELAHAVNACS HALNKANPRF PESLTRDTAT EIAINVKALY
1060 1070 1080 1090 1100
NETEALLVGR VPLHLESPHE ERVSSALHSV EMELQKLTEI PWLYYILRPS
1110 1120 1130 1140 1150
EDEEPPLDCT KRNNKSTVFR IVPKFKKEKA QKQKTSSQPV QNWGTEEVAA
1160 1170 1180 1190 1200
WLDLLNLGEY KEIFIRHDVR GAELLHLERR DLKDLGIPKV GHMKRILQGI
1210
KELERNPPNL V
Length:1,211
Mass (Da):134,132
Last modified:August 12, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i477C73A1142B3BB1
GO
Isoform 2 (identifier: D3YXJ0-2) [UniParc]FASTAAdd to basket
Also known as: DAG kinase eta-11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1140-1156: VQNWGTEEVAAWLDLLN → GPGDSESGSYEANSPGN
     1157-1211: Missing.

Show »
Length:1,156
Mass (Da):127,362
Checksum:i84962D1A01A72842
GO
Isoform 3 (identifier: D3YXJ0-3) [UniParc]FASTAAdd to basket
Also known as: DAG kinase eta-31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1033-1063: Missing.
     1140-1156: VQNWGTEEVAAWLDLLN → GPGDSESGSYEANSPGN
     1157-1211: Missing.

Show »
Length:1,125
Mass (Da):124,008
Checksum:iA9749D1B4E5D4EC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQ48A0A2I3BQ48_MOUSE
Diacylglycerol kinase
Dgkh
1,180Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0JP53A0JP53_MOUSE
Diacylglycerol kinase
Dgkh
1,078Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ43A0A2I3BQ43_MOUSE
Diacylglycerol kinase
Dgkh
1,032Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQA6A0A2I3BQA6_MOUSE
Diacylglycerol kinase eta
Dgkh
443Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0606681033 – 1063Missing in isoform 3. Add BLAST31
Alternative sequenceiVSP_0606691140 – 1156VQNWG…LDLLN → GPGDSESGSYEANSPGN in isoform 2 and isoform 3. Add BLAST17
Alternative sequenceiVSP_0606701157 – 1211Missing in isoform 2 and isoform 3. Add BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC124715 Genomic DNA No translation available.
AC126251 Genomic DNA No translation available.
AC161608 Genomic DNA No translation available.
KP329574 mRNA Translation: AJF98606.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074805.1, NM_001081336.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000074729; ENSMUSP00000074290; ENSMUSG00000034731 [D3YXJ0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
380921

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:380921

UCSC genome browser

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UCSCi
uc007uso.1, mouse [D3YXJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124715 Genomic DNA No translation available.
AC126251 Genomic DNA No translation available.
AC161608 Genomic DNA No translation available.
KP329574 mRNA Translation: AJF98606.1
RefSeqiNP_001074805.1, NM_001081336.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074290

PTM databases

iPTMnetiD3YXJ0
PhosphoSitePlusiD3YXJ0

Proteomic databases

EPDiD3YXJ0
MaxQBiD3YXJ0
PaxDbiD3YXJ0
PeptideAtlasiA0A0B5JC35
PRIDEiD3YXJ0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23454, 122 antibodies

Genome annotation databases

EnsembliENSMUST00000074729; ENSMUSP00000074290; ENSMUSG00000034731 [D3YXJ0-2]
GeneIDi380921
KEGGimmu:380921
UCSCiuc007uso.1, mouse [D3YXJ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
160851
MGIiMGI:2444188, Dgkh

Phylogenomic databases

eggNOGiKOG1170, Eukaryota
GeneTreeiENSGT00940000158106
HOGENOMiCLU_001799_3_0_1
InParanoidiD3YXJ0
OrthoDBi43384at2759
PhylomeDBiD3YXJ0
TreeFamiTF313104

Enzyme and pathway databases

UniPathwayiUPA00230

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
380921, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dgkh, mouse
RNActiD3YXJ0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034731, Expressed in dorsal root ganglion and 219 other tissues
ExpressionAtlasiD3YXJ0, baseline and differential
GenevisibleiD3YXJ0, MM

Family and domain databases

CDDicd00029, C1, 2 hits
Gene3Di1.10.150.50, 1 hit
2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001660, SAM
IPR013761, SAM/pointed_sf
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF00169, PH, 1 hit
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00233, PH, 1 hit
SM00454, SAM, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
SSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKH_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YXJ0
Secondary accession number(s): A0A0B5JC35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 12, 2020
Last sequence update: August 12, 2020
Last modified: December 2, 2020
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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