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Protein

Hemicentin-1

Gene

Hmcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos (PubMed:21215633). May play a role in the architecture of adhesive and flexible epithelial cell junctions (PubMed:17015624). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (PubMed:24951538).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Hemicentin-1Imported
Alternative name(s):
Fibulin-61 Publication
Short name:
FIBL-61 Publication
Gene namesi
Name:Hmcn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685047 Hmcn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Cell junction, Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Embryos arrest between the one- and four-cell stages with cleavage furrows that form but fail to ingress and often retract prior to completion, resulting in multinucleate cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500305310622 – 5634Hemicentin-1Sequence analysisAdd BLAST5613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi451 ↔ 499PROSITE-ProRule annotation
Disulfide bondi541 ↔ 591PROSITE-ProRule annotation
Glycosylationi615O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi633 ↔ 681PROSITE-ProRule annotation
Disulfide bondi723 ↔ 772PROSITE-ProRule annotation
Disulfide bondi814 ↔ 867PROSITE-ProRule annotation
Disulfide bondi911 ↔ 960PROSITE-ProRule annotation
Disulfide bondi1002 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1101 ↔ 1150PROSITE-ProRule annotation
Disulfide bondi1192 ↔ 1240PROSITE-ProRule annotation
Disulfide bondi1287 ↔ 1337PROSITE-ProRule annotation
Glycosylationi1292O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi1381 ↔ 1430PROSITE-ProRule annotation
Glycosylationi1386O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi1474 ↔ 1524PROSITE-ProRule annotation
Disulfide bondi1568 ↔ 1617PROSITE-ProRule annotation
Glycosylationi1639O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi1662 ↔ 1711PROSITE-ProRule annotation
Disulfide bondi1755 ↔ 1804PROSITE-ProRule annotation
Glycosylationi1826O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi1847 ↔ 1897PROSITE-ProRule annotation
Disulfide bondi1941 ↔ 1990PROSITE-ProRule annotation
Disulfide bondi2032 ↔ 2082PROSITE-ProRule annotation
Disulfide bondi2124 ↔ 2173PROSITE-ProRule annotation
Disulfide bondi2217 ↔ 2268PROSITE-ProRule annotation
Disulfide bondi2313 ↔ 2362PROSITE-ProRule annotation
Disulfide bondi2407 ↔ 2456PROSITE-ProRule annotation
Disulfide bondi2500 ↔ 2549PROSITE-ProRule annotation
Disulfide bondi2596 ↔ 2645PROSITE-ProRule annotation
Disulfide bondi2695 ↔ 2744PROSITE-ProRule annotation
Disulfide bondi2798 ↔ 2847PROSITE-ProRule annotation
Disulfide bondi2893 ↔ 2942PROSITE-ProRule annotation
Disulfide bondi2985 ↔ 3034PROSITE-ProRule annotation
Disulfide bondi3080 ↔ 3129PROSITE-ProRule annotation
Glycosylationi3151O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi3172 ↔ 3223PROSITE-ProRule annotation
Disulfide bondi3267 ↔ 3318PROSITE-ProRule annotation
Disulfide bondi3363 ↔ 3412PROSITE-ProRule annotation
Disulfide bondi3456 ↔ 3505PROSITE-ProRule annotation
Disulfide bondi3549 ↔ 3598PROSITE-ProRule annotation
Disulfide bondi3642 ↔ 3691PROSITE-ProRule annotation
Disulfide bondi3733 ↔ 3782PROSITE-ProRule annotation
Disulfide bondi3824 ↔ 3875PROSITE-ProRule annotation
Glycosylationi3897O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi3917 ↔ 3966PROSITE-ProRule annotation
Disulfide bondi4008 ↔ 4057PROSITE-ProRule annotation
Disulfide bondi4099 ↔ 4147PROSITE-ProRule annotation
Disulfide bondi4189 ↔ 4238PROSITE-ProRule annotation
Disulfide bondi4280 ↔ 4327PROSITE-ProRule annotation
Disulfide bondi4370 ↔ 4418PROSITE-ProRule annotation
Glycosylationi4379O-linked (GalNAc...) threonineSequence analysis1
Disulfide bondi4460 ↔ 4508PROSITE-ProRule annotation
Disulfide bondi4540 ↔ 4577PROSITE-ProRule annotation
Disulfide bondi4544 ↔ 4582PROSITE-ProRule annotation
Disulfide bondi4555 ↔ 4567PROSITE-ProRule annotation
Disulfide bondi4597 ↔ 4634PROSITE-ProRule annotation
Disulfide bondi4601 ↔ 4639PROSITE-ProRule annotation
Disulfide bondi4612 ↔ 4624PROSITE-ProRule annotation
Disulfide bondi4654 ↔ 4691PROSITE-ProRule annotation
Disulfide bondi4658 ↔ 4696PROSITE-ProRule annotation
Disulfide bondi4669 ↔ 4681PROSITE-ProRule annotation
Disulfide bondi4711 ↔ 4748PROSITE-ProRule annotation
Disulfide bondi4715 ↔ 4753PROSITE-ProRule annotation
Disulfide bondi4726 ↔ 4738PROSITE-ProRule annotation
Disulfide bondi4768 ↔ 4805PROSITE-ProRule annotation
Disulfide bondi4772 ↔ 4810PROSITE-ProRule annotation
Disulfide bondi4783 ↔ 4795PROSITE-ProRule annotation
Disulfide bondi4825 ↔ 4862PROSITE-ProRule annotation
Disulfide bondi4829 ↔ 4867PROSITE-ProRule annotation
Disulfide bondi4840 ↔ 4852PROSITE-ProRule annotation
Disulfide bondi5110 ↔ 5120PROSITE-ProRule annotation
Disulfide bondi5116 ↔ 5129PROSITE-ProRule annotation
Disulfide bondi5131 ↔ 5144PROSITE-ProRule annotation
Disulfide bondi5195 ↔ 5205PROSITE-ProRule annotation
Disulfide bondi5201 ↔ 5214PROSITE-ProRule annotation
Disulfide bondi5216 ↔ 5227PROSITE-ProRule annotation
Disulfide bondi5275 ↔ 5288PROSITE-ProRule annotation
Disulfide bondi5282 ↔ 5297PROSITE-ProRule annotation
Disulfide bondi5318 ↔ 5329PROSITE-ProRule annotation
Disulfide bondi5325 ↔ 5338PROSITE-ProRule annotation
Disulfide bondi5340 ↔ 5353PROSITE-ProRule annotation
Disulfide bondi5435 ↔ 5445PROSITE-ProRule annotation
Disulfide bondi5441 ↔ 5454PROSITE-ProRule annotation
Disulfide bondi5456 ↔ 5469PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiD3YXG0
PaxDbiD3YXG0
PRIDEiD3YXG0

PTM databases

iPTMnetiD3YXG0
PhosphoSitePlusiD3YXG0

Expressioni

Tissue specificityi

Expressed in vascular endothelial cells in coronary arteries and sparsely in endocardial endothelium (at protein level) (PubMed:24951538). Expressed in skin, tongue, lung and eye (PubMed:17015624).2 Publications

Inductioni

Up-regulated following myocardial infarction.1 Publication

Gene expression databases

BgeeiENSMUSG00000066842 Expressed in 170 organ(s), highest expression level in lung
ExpressionAtlasiD3YXG0 baseline and differential
GenevisibleiD3YXG0 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliD3YXG0
SMRiD3YXG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 216VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini431 – 517Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST87
Domaini520 – 607Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST88
Domaini612 – 697Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST86
Domaini702 – 788Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST87
Domaini793 – 883Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST91
Domaini890 – 976Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST87
Domaini981 – 1067Ig-like C2-type 7PROSITE-ProRule annotationAdd BLAST87
Domaini1072 – 1166Ig-like C2-type 8PROSITE-ProRule annotationAdd BLAST95
Domaini1171 – 1254Ig-like C2-type 9PROSITE-ProRule annotationAdd BLAST84
Domaini1261 – 1353Ig-like C2-type 10PROSITE-ProRule annotationAdd BLAST93
Domaini1357 – 1446Ig-like C2-type 11PROSITE-ProRule annotationAdd BLAST90
Domaini1451 – 1540Ig-like C2-type 12PROSITE-ProRule annotationAdd BLAST90
Domaini1545 – 1633Ig-like C2-type 13PROSITE-ProRule annotationAdd BLAST89
Domaini1638 – 1723Ig-like C2-type 14PROSITE-ProRule annotationAdd BLAST86
Domaini1732 – 1820Ig-like C2-type 15PROSITE-ProRule annotationAdd BLAST89
Domaini1825 – 1913Ig-like C2-type 16PROSITE-ProRule annotationAdd BLAST89
Domaini1918 – 2006Ig-like C2-type 17PROSITE-ProRule annotationAdd BLAST89
Domaini2011 – 2096Ig-like C2-type 18PROSITE-ProRule annotationAdd BLAST86
Domaini2103 – 2189Ig-like C2-type 19PROSITE-ProRule annotationAdd BLAST87
Domaini2194 – 2284Ig-like C2-type 20PROSITE-ProRule annotationAdd BLAST91
Domaini2289 – 2378Ig-like C2-type 21PROSITE-ProRule annotationAdd BLAST90
Domaini2383 – 2472Ig-like C2-type 22PROSITE-ProRule annotationAdd BLAST90
Domaini2477 – 2565Ig-like C2-type 23PROSITE-ProRule annotationAdd BLAST89
Domaini2570 – 2661Ig-like C2-type 24PROSITE-ProRule annotationAdd BLAST92
Domaini2665 – 2762Ig-like C2-type 25PROSITE-ProRule annotationAdd BLAST98
Domaini2765 – 2863Ig-like C2-type 26PROSITE-ProRule annotationAdd BLAST99
Domaini2867 – 2958Ig-like C2-type 27PROSITE-ProRule annotationAdd BLAST92
Domaini2962 – 3050Ig-like C2-type 28PROSITE-ProRule annotationAdd BLAST89
Domaini3055 – 3145Ig-like C2-type 29PROSITE-ProRule annotationAdd BLAST91
Domaini3155 – 3227Ig-like C2-type 30PROSITE-ProRule annotationAdd BLAST73
Domaini3244 – 3334Ig-like C2-type 31PROSITE-ProRule annotationAdd BLAST91
Domaini3339 – 3428Ig-like C2-type 32PROSITE-ProRule annotationAdd BLAST90
Domaini3433 – 3515Ig-like C2-type 33PROSITE-ProRule annotationAdd BLAST83
Domaini3526 – 3614Ig-like C2-type 34PROSITE-ProRule annotationAdd BLAST89
Domaini3619 – 3707Ig-like C2-type 35PROSITE-ProRule annotationAdd BLAST89
Domaini3712 – 3798Ig-like C2-type 36PROSITE-ProRule annotationAdd BLAST87
Domaini3803 – 3891Ig-like C2-type 37PROSITE-ProRule annotationAdd BLAST89
Domaini3896 – 3982Ig-like C2-type 38PROSITE-ProRule annotationAdd BLAST87
Domaini3987 – 4073Ig-like C2-type 39PROSITE-ProRule annotationAdd BLAST87
Domaini4077 – 4163Ig-like C2-type 40PROSITE-ProRule annotationAdd BLAST87
Domaini4168 – 4252Ig-like C2-type 41PROSITE-ProRule annotationAdd BLAST85
Domaini4259 – 4332Ig-like C2-type 42PROSITE-ProRule annotationAdd BLAST74
Domaini4347 – 4434Ig-like C2-type 43PROSITE-ProRule annotationAdd BLAST88
Domaini4439 – 4526Ig-like C2-type 44PROSITE-ProRule annotationAdd BLAST88
Domaini4528 – 4583TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini4585 – 4640TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini4642 – 4697TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini4699 – 4754TSP type-1 4PROSITE-ProRule annotationAdd BLAST56
Domaini4756 – 4811TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini4813 – 4868TSP type-1 6PROSITE-ProRule annotationAdd BLAST56
Domaini4870 – 5092Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST223
Domaini5106 – 5145EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini5146 – 5189EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini5191 – 5228EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini5229 – 5269EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini5271 – 5306EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini5314 – 5354EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini5431 – 5470EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4475 Eukaryota
ENOG410ZN3C LUCA
GeneTreeiENSGT00860000133679
HOGENOMiHOG000231553
InParanoidiD3YXG0
KOiK17341
OrthoDBiEOG091G015K
PhylomeDBiD3YXG0

Family and domain databases

CDDicd00255 nidG2, 1 hit
Gene3Di2.20.100.10, 5 hits
2.60.40.10, 44 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 6 hits
PF07474 G2F, 1 hit
PF07679 I-set, 33 hits
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00179 EGF_CA, 8 hits
SM00682 G2F, 1 hit
SM00409 IG, 44 hits
SM00408 IGc2, 44 hits
SM00406 IGv, 14 hits
SM00209 TSP1, 6 hits
SUPFAMiSSF48726 SSF48726, 44 hits
SSF53300 SSF53300, 1 hit
SSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 3 hits
SSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 5 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 8 hits
PS50835 IG_LIKE, 43 hits
PS50993 NIDOGEN_G2, 1 hit
PS50092 TSP1, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: D3YXG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MIAQEVVHTV FLVALFRSSL AGDGTPQSES RAEEIPEGAS TLAFVFDVTG
60 70 80 90 100
SMYDDLVQVI EGASKILETS LKRPKRPLYN FALVPFHDPE IGPVTITTDP
110 120 130 140 150
KKFQYELREL YVQGGGDCPE MSIGAIKIAL EISLPGSFIY VFTDARSKDY
160 170 180 190 200
RLTHEVLQLI QQKQSQVVFV LTGDCDDRNH IGYKVYEEIA STSSGQVFHL
210 220 230 240 250
DKKQVNEVLK WVEEAVQASK VHLLSTDHLE HAVNTWKIPF DPSLKEVTVS
260 270 280 290 300
LSGPSPVIEI RNPFGKLIKK GFGLNELLNI HNSAKVVNVK EPEAGMWTVK
310 320 330 340 350
TSSSGRHSVR ITGLSTIDFR AGFSRKPTLD FKKTMSRPVQ GIPTYVLLNT
360 370 380 390 400
SGISSPARVD RLELLSISGG SLKTIPVKHY PDRKPYGIWN ISDFIPPDEA
410 420 430 440 450
FFLKVTGYDK DGYLFQRVSS VSFSSIVPDA PKVTMPTRTL GYYLQPGQIL
460 470 480 490 500
CSVESFLPFT LSFMRDGIAL GVDQYLRESA SVNWDFTKVT LSDEGFYDCI
510 520 530 540 550
AVSSAGTGRA QTFFDVSEPP PIIQLPNNVT VTPGERAVLA CLVISAVDYN
560 570 580 590 600
LTWQRSGRDI RLADSARIRT LANLSLELRS VKIGDAGEYR CVVSSEGGSA
610 620 630 640 650
AASVFLTVQE KPKVTVMPKN QSFTGGSEIS IMCSATGYPK PKIVWTMNEM
660 670 680 690 700
FIMGSHRYRM TSEGTLFIKN AVPKDAGTYA CLASNAAGTD KQTSTLRYIE
710 720 730 740 750
APKLVVEQSE LLVALGDTTV MECKTSGIPP PQVKWFKGDL ELRPSTFLSI
760 770 780 790 800
DPLVGLLKIQ ETQDLDAGDY TCVAINEAGR ATGRLTLDVG SPPVFIQEPS
810 820 830 840 850
DVAVEIGSNV TLPCYVQGYP EPKIKWRRLD NMPVFSRPFS VSFISQLRTG
860 870 880 890 900
ALFISNLWAS DKGTYICEAE NQFGKIQSQT TVTVTGLVAP LIGISPSMAS
910 920 930 940 950
VIEGQPLTLP CTLLAGNPIP ERRWMKNSAM LVQNPYITVR SDGSLHIERV
960 970 980 990 1000
RLQDGGKYTC VASNVAGTNN KTTSVAVHVL PSIQHGQQIL STIEGVPVTL
1010 1020 1030 1040 1050
PCRASGIPKP SITWSKKGEL ISTSSAKFSA GADGSLYVVS PGSEESGEYI
1060 1070 1080 1090 1100
CTATNAAGYA KRKVQLTVYV RPRVFGDQRG LSQDKPVEIS VLAGEEAILP
1110 1120 1130 1140 1150
CEAKSLPPPI ITWAKDSQLI SPFSPRHTFL PSGSMKITET RVSDSGMYLC
1160 1170 1180 1190 1200
VATNIAGNVT QSVKLSVHVP PKIQHGNRHI KVQVGQRVDI LCNAHGSPPP
1210 1220 1230 1240 1250
VITWFKSGRP FLDGAQHPGS PDGTLSIEQA VISDAGVYTC AATNIAGSDE
1260 1270 1280 1290 1300
AEVTLHVQEP PSVEDLQPPF NTPFQERLAN QRIEFPCPAK GTPKPTIKWL
1310 1320 1330 1340 1350
HNGREVTGQE PGVSILEDGA LLVIASVTPH NNGEYICVAV NEAGTTERKY
1360 1370 1380 1390 1400
NLKVHVPPVI RDKEHVTNVS VLTSQLASLY CEVEGTPSPV ITWYKDDIQV
1410 1420 1430 1440 1450
TESSTVQIVN NGKILKLFKV SAEDAGRYSC KAINIAGTSQ KDFSVNVLVP
1460 1470 1480 1490 1500
PSILGASSPS EVSVVLNHNV TLQCPGTGVP FPAIHWFKDG KPLFLGDPNI
1510 1520 1530 1540 1550
ELSDRGQSLH LRNARRSDKG RYQCTVSNAA GKQAKDIKLT VYVPPSIKGG
1560 1570 1580 1590 1600
NITTEISALL NSIVKLECET RGLPVPAITW YKDGQVVTSS SQALYIDKGQ
1610 1620 1630 1640 1650
LLHIQRAQVS DSATYTCHAA NVAGTAEKSF HVDIYVPPTI EGDLTAPSNK
1660 1670 1680 1690 1700
QVIIGQSLIL ECKAAGNPPP ILTWLKDGVP VKASDNIHIE AGGKKLEILS
1710 1720 1730 1740 1750
ALEVDRGQYI CVATSVAGER EIKYEVDVLV PPAVEGGEET SYFIVLANNL
1760 1770 1780 1790 1800
LELDCQVSGS PPPTIMWLKG GQLIDERDGF KILLNGRKLV IAQAQVSDTG
1810 1820 1830 1840 1850
LYQCVATNIA GDHRKEFEVT VHVPPTIKSS DLPEKTVVRY KPVTLQCIAN
1860 1870 1880 1890 1900
GIPNPSITWL KDDQPVNTAH GNLKIQSSGR VLQIAKALLE DAGRYTCVAT
1910 1920 1930 1940 1950
NAAGEAHQHT QLHVHEPPSL DDAGKMRNET VVVNNPIQLE CKATGKPLPV
1960 1970 1980 1990 2000
ITWYKDSHPL SGSASAAFLK RGQVLEIGSA QISDAGIYKC VAINSAGATE
2010 2020 2030 2040 2050
LFYSLQVHVP PSISGSSSMV EVVVNNLARL ECEARGIPAP SLTWLKDGSP
2060 2070 2080 2090 2100
VSSFSNGIQI LSGGRILALT SAQMSDAGRY TCVAVNAAGE KQRDIDLRVY
2110 2120 2130 2140 2150
APPNIMGEEQ NVSVLIGQAV ELFCQSDAVP PPTLMWLKDG RPLLKRPGLS
2160 2170 2180 2190 2200
ISENGSVLKI EDAQAGDTGR YTCEATNVAG KTEKNYNVNV WVPPSIYGSD
2210 2220 2230 2240 2250
ELVQLTAIEG NLITLLCESS GIPPPDLTWK KKGSLVLADS AGRVHILSGG
2260 2270 2280 2290 2300
RRLQISIAEK ADAGLYTCVA SNVAGVAKKE YNLQVYIRPS ITNSGGHRPE
2310 2320 2330 2340 2350
ITVIRGKSIS LECEVQGIPQ PTVTWMKDGR PLTKGKGVEI LDEGRILQLK
2360 2370 2380 2390 2400
NVHVSDTGRY VCVAVNVAGM TDKRYDLSVH APPSIIGNHG VPENVSVVEK
2410 2420 2430 2440 2450
SSVSLTCEAS GIPLPSITWL KDGWPVNLGS SVKILSGGRM LRLMQTRPED
2460 2470 2480 2490 2500
AGQYTCIVRN AAGEDRKMFG LSVLVPPHIV GENTLEDVKI KEKQSVTLTC
2510 2520 2530 2540 2550
EVRGNPVPQI TWHKDGQLLQ EDEAHHMMSG GRFLQITNAQ VSHTGRYTCL
2560 2570 2580 2590 2600
ASNIAGDKSK SFRLNVFVSP TIAGVDSDGS PEDVIVILNS PTSLVCEAYS
2610 2620 2630 2640 2650
YPPATITWFK DGTPLESNRN IRILPGGRTL QILNAQEDNA GRYSCVATNE
2660 2670 2680 2690 2700
AGEKIKHYEV KVYIPPIIKK GDLLGPGLSP KEVKIRVNSS LTLECEAYAI
2710 2720 2730 2740 2750
PSASLRWYKD GQPLKSDDHV TIAASGHTLQ IKEAQISDTG RYTCVASNLA
2760 2770 2780 2790 2800
GEDELDFDVN IQVPPSFQKL WEIGNMLDTG RSGEAKDVII NNPLSLHCET
2810 2820 2830 2840 2850
NAAPPPTLTW YKDGRPLTSS DRVLILPGGR VLQIPRAKVE DAGRYTCVAV
2860 2870 2880 2890 2900
NEAGEDSLRY DVHVLLPPVI KGANSDLPEE VTVLVNKSTQ MECSSSGNPA
2910 2920 2930 2940 2950
PRNYWQKDGQ ILLEDEHHKF QSDGRSLQIL NAQITDTGRY VCVAENTAGS
2960 2970 2980 2990 3000
AKKYFNLNVH VPPSVIGPNH EHLSVVVNHF ISLNCEVSGF PPPDLSWLKN
3010 3020 3030 3040 3050
EEPIKPNTNV LTVPGGRTLQ IIRAKISDGG DYTCIAINQA GESKKKVSLT
3060 3070 3080 3090 3100
VHVPPSIKDH GSQSLSIVNV REGTSVSLEC ESNAVPPPVI TWSKNGRMIP
3110 3120 3130 3140 3150
DSTNVEILTG GQTLHIRRAE VSDTGQYVCR AINVAGRDDK NFHLNVYVPP
3160 3170 3180 3190 3200
TIEGPETEVI VETISNPVTL TCDATGIPPP TITWLKNHKP IENSDPLEVH
3210 3220 3230 3240 3250
ILSGGSKLQI ARPQRSNSGN YTCVASNMEG KAQKNFILFI QVPPSVAGAE
3260 3270 3280 3290 3300
VPSEVSVLLG ENVELVCNAD GIPTPHLQWL RDGKPIVNGE TERVRVTTDG
3310 3320 3330 3340 3350
STLNIYRALT SDMGKYTCVA TNPAGEEDRI FNLNVYVPPK IRGNKEEAEK
3360 3370 3380 3390 3400
LMALVDTSIN IECKATGTPP PQINWLKNGL PLPISSHIRL LSAGQVVRIV
3410 3420 3430 3440 3450
RAQVSDIAVY TCVASNRAGV DSKHYSLQVF VPPNMDNAMG TEEITIVKGS
3460 3470 3480 3490 3500
STSMTCFTDG TPAPSMSWLR DGQPLAPDAH LTVSTQGMVL QLIKAETEDT
3510 3520 3530 3540 3550
GKYTCVATNE AGEVSKHFVL KVLEPPHING SEGPGEVSVI VNNPLELSCI
3560 3570 3580 3590 3600
ASGIPAPKIS WMKDGRPFLQ TEQVQTLEGG AILRVSSAQV EDTGRYTCLA
3610 3620 3630 3640 3650
SSPAGDDDKE YLVRVHVPPN IAGMDEAQDF TVLRNRQVTL ECKSDAVPPP
3660 3670 3680 3690 3700
VIMWLKNREQ LQATPRVRIL SGGRYLQINN ADLGDTANYT CVASNIAGKT
3710 3720 3730 3740 3750
TREFNLTVNV PPSIGGGPQS LVTLLNKSIA LECRAEGVPA PRITWRKDGV
3760 3770 3780 3790 3800
VLAESHARYS ILENGFLHIE SAHVTDTGRY LCMATNVAGT DRRRIDLQVH
3810 3820 3830 3840 3850
VPPSIAMGPT NVTVTVNVQT TLACEATGIP KPSVTWRKNG HLLNVDQNQN
3860 3870 3880 3890 3900
SYRLLSSGSL VIISPSVDDT ASYECTVTSD AGEDKRAVDL TVQVPPTIAD
3910 3920 3930 3940 3950
EPMDFLVTRQ APAVMTCSAS GVPVPSIHWT KNGLRLLPRG DGYRILSSGA
3960 3970 3980 3990 4000
IEIPTTQLNH AGRYTCVARN AAGSAHRHVT LRVQEPPVIQ PQPSELDVIL
4010 4020 4030 4040 4050
NNPILLPCEA TGIPTPFITW QKEGINVITS GKSLAILPSG SLQISRAVRG
4060 4070 4080 4090 4100
DAGTYMCVAQ NPAGTALGKV KLNVQVPPVI SSHQKEYVVT MDKPVSLLCE
4110 4120 4130 4140 4150
TEGSPPPDIT WHKDGHALTE SIRQRILNSG ALQIAFAQPD DAGQYTCMAA
4160 4170 4180 4190 4200
NMAGSSSVSS TLTVHVPPRI QSTEVHFTVN ENSQAVLPCV ADGIPTPAIH
4210 4220 4230 4240 4250
WEKDGVLIAN LLGKYTAQPY GELILENVVL EDSGTYTCVA NNAAGEDTRI
4260 4270 4280 4290 4300
VTLAVHTLPT FTELPGDLSL NKGEQLRLSC KAVGIPLPKL TWTFNNNIIP
4310 4320 4330 4340 4350
AHFDSINGHS ELVIEKVSKE DSGTYVCTAE NSVGFVKAIG FVYVKEPPVF
4360 4370 4380 4390 4400
KGDYPSNWIE PLGGNAILNC EVKGDPAPTI QWSRKGADIE ISHRIRQLGN
4410 4420 4430 4440 4450
GSLAIYGTVN EDAGDYTCVA ANEAGMVERS MSLTLQSSPI ITLEPVETVV
4460 4470 4480 4490 4500
DAGGRVILDC QAAGEPQPTI TWSRQGQPIS WDNRLSMLPN SSLYIAAARK
4510 4520 4530 4540 4550
EDTSEYECVA RNLMGSVLVR VPVIVQVHGG FSLWSAWRPC SVTCGKGIQK
4560 4570 4580 4590 4600
RSRLCDNPPP ANGGRPCQGA DSEARHCHNK LCPVDGHWSE WSFWEDCSRS
4610 4620 4630 4640 4650
CGHGNQTRTR TCSNPPAQHG GRPCEGHAVE TIMCNIRPCP VHGVWNAWQP
4660 4670 4680 4690 4700
WSACSKSCGK GSQTRMRLCN NPPPSFGGAH CSGAETQMQV CNERHCPVDG
4710 4720 4730 4740 4750
RWATWSSWSA CTVSCGGGAR KRTRDCSDPV PQYGGNKCEG TGVQSDFCNS
4760 4770 4780 4790 4800
DPCPTHGNWS PWSGWGTCSR TCNGGQMRRY RTCDNPRPSN GGRACGGPDT
4810 4820 4830 4840 4850
QIQRCNTDMC PVDGSWGTWH SWSHCSVSCG GGERTRKRLC DNPVPTKGGR
4860 4870 4880 4890 4900
SCPGDATQVS RCNMQACPGG PQRARGSVIG NINDIEFGIA FLNATITDSP
4910 4920 4930 4940 4950
NTDTRVIQAK ITNVPRSLGP AMRKIISILN PIYWTTAKEI GEAVNGFTLT
4960 4970 4980 4990 5000
NAVFKRETQV EFATGEVLRM THVARGLDSD GALLLDVIVS GQVLQLHSPA
5010 5020 5030 5040 5050
EVGVKDYTED YIQTGPGQLY AYSTRLFTID GISIPYTWNH TIFYDQAWGK
5060 5070 5080 5090 5100
MPFLVETLHA SSIESDYNQL EETLGFKIHA SISKGDRSNQ CPSGFILDSV
5110 5120 5130 5140 5150
GPFCADEDEC TAGNPCSHTC HNAIGAYYCS CPKGLTIAAD GRTCQDIDEC
5160 5170 5180 5190 5200
ALGGHTCRAG QDCDNTIGSY RCVVHCGTGF RRTSDGLSCQ DINECQESSP
5210 5220 5230 5240 5250
CHQRCFNVIG SFHCGCEAGY QLKGRKCIDV NECRQNVCRP DQHCKNTRGG
5260 5270 5280 5290 5300
YKCIDLCPSG MTKAENGTCI DIDECKDGTH QCRYNQICEN TRGSYRCACP
5310 5320 5330 5340 5350
RGYRSQGVGR PCIDINECEQ VPKPCAHQCS NSPGSFKCIC LPGQQLLGDG
5360 5370 5380 5390 5400
KSCAGLERLS NYGTQYSSYT LERFSPVRSD YQPSQHYRQY SQLYSSYSEY
5410 5420 5430 5440 5450
RNSRASFSRN RRTIRKTCPE GSEANHETCV DIDECQNRDT CQHECKNTIG
5460 5470 5480 5490 5500
SYQCVCPPGY RLMLNGKTCQ DVDECLEQNV RCGPNRMCFN MRGSYQCIDT
5510 5520 5530 5540 5550
PCPPNYQRDP VLGFCLKNCP PNDLECTLSP YALEYKLVSL PFGIAANQDL
5560 5570 5580 5590 5600
IRLVAYTQDG VMHPRTTFLM IDEEPAVPFA LRDENLKGVV YTTRPLREAE
5610 5620 5630
TYRMKVGALS YSANGTIEYQ TTFIVYIAVS AYPY
Length:5,634
Mass (Da):611,561
Last modified:April 20, 2010 - v1
Checksum:i38F277C227773C1C
GO
Isoform 2 (identifier: D3YXG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5316-5432: Missing.

Note: No experimental confirmation available.
Show »
Length:5,517
Mass (Da):598,259
Checksum:iAF326B188765F9D8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJH2H3BJH2_MOUSE
Hemicentin-1
Hmcn1
155Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0585265316 – 5432Missing in isoform 2. Add BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111145 Genomic DNA No translation available.
AC113326 Genomic DNA No translation available.
AC115051 Genomic DNA No translation available.
AC124120 Genomic DNA No translation available.
CCDSiCCDS15357.2 [D3YXG0-1]
RefSeqiNP_001019891.2, NM_001024720.3 [D3YXG0-1]
UniGeneiMm.379425

Genome annotation databases

EnsembliENSMUST00000074783; ENSMUSP00000074340; ENSMUSG00000066842 [D3YXG0-1]
ENSMUST00000137197; ENSMUSP00000121500; ENSMUSG00000066842 [D3YXG0-2]
GeneIDi545370
KEGGimmu:545370
UCSCiuc007cyj.1 mouse [D3YXG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111145 Genomic DNA No translation available.
AC113326 Genomic DNA No translation available.
AC115051 Genomic DNA No translation available.
AC124120 Genomic DNA No translation available.
CCDSiCCDS15357.2 [D3YXG0-1]
RefSeqiNP_001019891.2, NM_001024720.3 [D3YXG0-1]
UniGeneiMm.379425

3D structure databases

ProteinModelPortaliD3YXG0
SMRiD3YXG0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiD3YXG0
PhosphoSitePlusiD3YXG0

Proteomic databases

MaxQBiD3YXG0
PaxDbiD3YXG0
PRIDEiD3YXG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074783; ENSMUSP00000074340; ENSMUSG00000066842 [D3YXG0-1]
ENSMUST00000137197; ENSMUSP00000121500; ENSMUSG00000066842 [D3YXG0-2]
GeneIDi545370
KEGGimmu:545370
UCSCiuc007cyj.1 mouse [D3YXG0-1]

Organism-specific databases

CTDi83872
MGIiMGI:2685047 Hmcn1

Phylogenomic databases

eggNOGiKOG4475 Eukaryota
ENOG410ZN3C LUCA
GeneTreeiENSGT00860000133679
HOGENOMiHOG000231553
InParanoidiD3YXG0
KOiK17341
OrthoDBiEOG091G015K
PhylomeDBiD3YXG0

Miscellaneous databases

PROiPR:D3YXG0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066842 Expressed in 170 organ(s), highest expression level in lung
ExpressionAtlasiD3YXG0 baseline and differential
GenevisibleiD3YXG0 MM

Family and domain databases

CDDicd00255 nidG2, 1 hit
Gene3Di2.20.100.10, 5 hits
2.60.40.10, 44 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 6 hits
PF07474 G2F, 1 hit
PF07679 I-set, 33 hits
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00179 EGF_CA, 8 hits
SM00682 G2F, 1 hit
SM00409 IG, 44 hits
SM00408 IGc2, 44 hits
SM00406 IGv, 14 hits
SM00209 TSP1, 6 hits
SUPFAMiSSF48726 SSF48726, 44 hits
SSF53300 SSF53300, 1 hit
SSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 3 hits
SSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 5 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 8 hits
PS50835 IG_LIKE, 43 hits
PS50993 NIDOGEN_G2, 1 hit
PS50092 TSP1, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHMCN1_MOUSE
AccessioniPrimary (citable) accession number: D3YXG0
Secondary accession number(s): D3Z2Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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