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Entry version 76 (08 May 2019)
Sequence version 2 (03 Oct 2012)
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Protein
Submitted name:

Complement component 7

Gene

C7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-166665 Terminal pathway of complement
R-MMU-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Complement component 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88235 C7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305273223 – 845Sequence analysisAdd BLAST823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi91 ↔ 109PROSITE-ProRule annotation
Disulfide bondi599 ↔ 626PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3YXF5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3YXF5

PeptideAtlas

More...
PeptideAtlasi
D3YXF5

PRoteomics IDEntifications database

More...
PRIDEi
D3YXF5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3YXF5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3YXF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079105 Expressed in 15 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000106317

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YXF5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 456MACPFInterPro annotationAdd BLAST335
Domaini569 – 628SushiInterPro annotationAdd BLAST60
Domaini629 – 690SushiInterPro annotationAdd BLAST62

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDXP Eukaryota
ENOG410YJ70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156804

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3YXF5

KEGG Orthology (KO)

More...
KOi
K03996

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNSSWSY

Database of Orthologous Groups

More...
OrthoDBi
100680at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330498

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 2 hits
cd00112 LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 2 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037564 Complement_C7
IPR003884 FacI_MAC
IPR040729 Kazal_3
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45742:SF2 PTHR45742:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18434 Kazal_3, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00084 Sushi, 2 hits
PF00090 TSP_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00764 COMPLEMENTC9

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 2 hits
SM00057 FIMAC, 2 hits
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 1 hit
SSF57535 SSF57535, 2 hits
SSF82895 SSF82895, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50923 SUSHI, 2 hits
PS50092 TSP1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3YXF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVTSLLILV CFIAAFQVFS RASSPVNCKW DSYGPWSECN GCTKTQTRRR
60 70 80 90 100
SVAVYGQYGG YPCEGSAFET QSCKPERGCP TEEGCGDRFR CFSGQCISKS
110 120 130 140 150
LVCNGDPDCE EDGADEDKCE NVANPSCNID KPPPNIELTG YGYNVVTGQG
160 170 180 190 200
KKRVINTKSF GGQCRKVFSG DGKDFYRLSG NILSYTFQVK VDNDFNYEFY
210 220 230 240 250
NSSWSYIKHT STEQNTFYSW KGLFSHSRNT YGHGSAKEEI DTKMKSYKLL
260 270 280 290 300
VVQNTVEVAQ FTNNNPEFLQ VAEPFWKELS HLPTLYDYSA YRRLIDQYGT
310 320 330 340 350
HYLQSGSLGG EYRVLFYVDS GSAKETGFQS DQDNACSSAD FQFLFTSSAD
360 370 380 390 400
QRCMKQLETE KSTSGNKGRL LRGKPLVRGG DSGFVADLSF LDLDNPAGNK
410 420 430 440 450
QRYSSWAGSV TRLPQVIKEK LAPLYELVKE VPCASVKRLY LKRAIEEYFD
460 470 480 490 500
EFDPCHCRPC QNGGLAIVVE TQCQCLCKPY TFGSACEQGV LVGDQAGGVD
510 520 530 540 550
GGWNCWSSWS PCVQGKRTRS RECNNPPPRD DGKSCLGETT ESKQCEDQDL
560 570 580 590 600
EKLRLLEPHC FHSSLAPKEF CLSPPALKDG FVQGEGTMVP VGQSVVYACD
610 620 630 640 650
EGYSLIGDPV ARCGEDLQWL VGEMHCQKLA CVLPGEMNGM QSHPQKPFYM
660 670 680 690 700
VGEKVTLSCV GGMSLEGPST LLCGSSLKWS PELKDAKCVQ KATSTPPPAA
710 720 730 740 750
PACQPWEKLQ NSKCICKMPY ECGSSLDVCA RDESRNKILS LTICKMHVVH
760 770 780 790 800
CHKRNYTLVG KESCTLPSPA EKVCGACPIW SKCDAQNGKC ICREASECQT
810 820 830 840
AGYRICVEVN GKEETMSECE AGILRCRGQS ISITAIKPCA EEAAQ
Length:845
Mass (Da):93,337
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11DC75F420092275
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC115877 Genomic DNA No translation available.
AC131919 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001230766.1, NM_001243837.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110689; ENSMUSP00000106317; ENSMUSG00000079105

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:109828

UCSC genome browser

More...
UCSCi
uc011zqy.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115877 Genomic DNA No translation available.
AC131919 Genomic DNA No translation available.
RefSeqiNP_001230766.1, NM_001243837.1

3D structure databases

SMRiD3YXF5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106317

PTM databases

iPTMnetiD3YXF5
PhosphoSitePlusiD3YXF5

Proteomic databases

MaxQBiD3YXF5
PaxDbiD3YXF5
PeptideAtlasiD3YXF5
PRIDEiD3YXF5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110689; ENSMUSP00000106317; ENSMUSG00000079105
GeneIDi109828
KEGGimmu:109828
UCSCiuc011zqy.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
730
MGIiMGI:88235 C7

Phylogenomic databases

eggNOGiENOG410IDXP Eukaryota
ENOG410YJ70 LUCA
GeneTreeiENSGT00940000156804
InParanoidiD3YXF5
KOiK03996
OMAiYNSSWSY
OrthoDBi100680at2759
TreeFamiTF330498

Enzyme and pathway databases

ReactomeiR-MMU-166665 Terminal pathway of complement
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Oxr1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079105 Expressed in 15 organ(s), highest expression level in lung

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR037564 Complement_C7
IPR003884 FacI_MAC
IPR040729 Kazal_3
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR45742:SF2 PTHR45742:SF2, 1 hit
PfamiView protein in Pfam
PF18434 Kazal_3, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00084 Sushi, 2 hits
PF00090 TSP_1, 2 hits
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00057 FIMAC, 2 hits
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 2 hits
SUPFAMiSSF57424 SSF57424, 1 hit
SSF57535 SSF57535, 2 hits
SSF82895 SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50923 SUSHI, 2 hits
PS50092 TSP1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YXF5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YXF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: October 3, 2012
Last modified: May 8, 2019
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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