Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 100 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Diacylglycerol kinase iota

Gene

Dgki

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (By similarity).

By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway (PubMed:15894621).

May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (PubMed:21119615).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri172 – 227Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri245 – 304Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114508, Effects of PIP2 hydrolysis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00230

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase iota1 Publication (EC:2.7.1.107By similarity)
Short name:
DAG kinase iota1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DgkiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443430, Dgki

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000038665

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous knockout mice lacking Dgki do not display overt phenotype (PubMed:15894621). They are slower to habituation to a novel environment, but have normal levels of locomotor activity, anxiety, and motor coordination (PubMed:21119615). They display a small increase in presynaptic release probability and synapses show a reduction in metabotropic glutamate receptor-dependent long-term depression (PubMed:21119615).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004516981 – 1071Diacylglycerol kinase iotaAdd BLAST1071

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3YWQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3YWQ0

PeptideAtlas

More...
PeptideAtlasi
D3YWQ0

PRoteomics IDEntifications database

More...
PRIDEi
D3YWQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
350765
361049 [D3YWQ0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3YWQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3YWQ0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D3YWQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In brain, expressed in the hippocampus and cerebellum with stronger expression in the Purkinje cell layer (at protein level) (PubMed:21119615). Expressed in kidney (PubMed:15894621).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038665, Expressed in cerebral cortex and 103 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3YWQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YWQ0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PDZ-binding motif) with DLG4; controls the localization of DGKI to the synapse (By similarity).

Interacts (via PDZ-binding motif) with DLG1 (By similarity).

Interacts (via PDZ-binding motif) with DLG2 (By similarity).

Interacts (via PDZ-binding motif) with DLG3 (PubMed:21119615). May interact with RASGRP3; involved in the regulation of RASGRP3 activity (Probable).

By similarity1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3YWQ0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099071

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
D3YWQ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YWQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini367 – 502DAGKcPROSITE-ProRule annotationAdd BLAST136
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati964 – 993ANK 1Sequence analysisAdd BLAST30
Repeati1000 – 1029ANK 2Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 74DisorderedSequence analysisAdd BLAST22
Regioni92 – 111DisorderedSequence analysisAdd BLAST20
Regioni328 – 356DisorderedSequence analysisAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1069 – 1071PDZ-bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Polar residuesSequence analysisAdd BLAST18
Compositional biasi328 – 344Basic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 227Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri245 – 304Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0782, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3YWQ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
TREPAMD

Database of Orthologous Groups

More...
OrthoDBi
274339at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3YWQ0

TreeFam database of animal gene trees

More...
TreeFami
TF312817

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd

The PANTHER Classification System

More...
PANTHERi
PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00130, C1_1, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111331, SSF111331, 1 hit
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50146, DAGK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: D3YWQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAAGRGCHL LPLPAARGPA RAPAASSALS PTGLCSGTTS ASFAAAGAVA
60 70 80 90 100
MNPSSSAGEE RGATGGSSSS GSGAGSCCLG AEGGADPRGA GAAAAAALEE
110 120 130 140 150
PAAAGQKEKE EALEEKLRDL TFRKQVSYRK AISRTGLQHL APAHPLGLPV
160 170 180 190 200
ANGPAKEPRA TLDWSENAVN GEHLWLETNV SGDLCYLGEE NCQVRFAKSA
210 220 230 240 250
LRRKCAVCKI VVHTACIEQL EKINFRCKPT FREGGSRSPR ENFVRHHWVH
260 270 280 290 300
RRRQEGKCKQ CGKGFQQKFS FHSKEIVAIS CSWCKQAFHN KVTCFMLHHI
310 320 330 340 350
EEPCSLGAHA AVIVPPTWII KVKKPQNSLK ASNRKKKRTS FKRKASKRGT
360 370 380 390 400
EQETKGRPFV IKPISSPLMK PLLVFVNPKS GGNQGTKVLQ MFMWYLNPRQ
410 420 430 440 450
VFDLSQEGPK DALEMYRKVP NLRILACGGD GTVGWILSIL DELQLSPQPP
460 470 480 490 500
VGVLPLGTGN DLARTLNWGG GYTDEPVSKI LCQVEDGTIV QLDRWNLHVE
510 520 530 540 550
RNPDLPPEEL EDGVCKLPLN VFNNYFSLGF DAHVTLEFHE SREANPEKFN
560 570 580 590 600
SRFRNKMFYA GAAFSDFLQR SSRDLSKHVK VVCDGTDLTP KIQDLKFQCI
610 620 630 640 650
VFLNIPRYCA GTMPWGNPGD HHDFEPQRHD DGYIEVIGFT MASLAALQVG
660 670 680 690 700
GHGERLHQCR EVMLLTYKSI PMQVDGEPCR LAPAMIRISL RNQANMVQKS
710 720 730 740 750
KRRTSMPLLN DIHQVQAADL RRVSAPPGSF TIPQSVPDRL RIRVNKISLQ
760 770 780 790 800
DYEGLHYDKD KLREASIPLG ILVVRGDCDL ETCRMYIDRL QEDLQSVSSG
810 820 830 840 850
SQRVHYQDQE TSFPRALSAQ RLSPRWCFLD ATSADRFYRI DRSQEHLHFV
860 870 880 890 900
MEISHDEIFI LDPDMVVSQQ AGTPPGMPDL VVEQASGLSD WWNPALRKRM
910 920 930 940 950
LSDSGMITPH YEDSDLKDFS HSRVLQSPVS SEDHAILQAV LTGDLMKLME
960 970 980 990 1000
SYKNGGSLLI QGPGHCSLLH YAAKTGNGDI VKYILDHGPA ELLDMADSET
1010 1020 1030 1040 1050
GETALHKAAC QRNRAVCQLL VDAGASLRQT DSKGKTPQER AQQAGDPDLA
1060 1070
AYLESRQNYK IIGHEDLETA V
Length:1,071
Mass (Da):118,209
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i407FD700231F89ED
GO
Isoform 2 (identifier: D3YWQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-732: Missing.

Show »
Length:1,050
Mass (Da):115,963
Checksum:i629C08C4362CE129
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z519D3Z519_MOUSE
Diacylglycerol kinase
Dgki
899Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R215S4R215_MOUSE
Diacylglycerol kinase
Dgki
591Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2G0S4R2G0_MOUSE
Diacylglycerol kinase
Dgki
841Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060832712 – 732Missing in isoform 2. Add BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC114574 Genomic DNA No translation available.
AC154019 Genomic DNA No translation available.
AC159480 Genomic DNA No translation available.
AC184160 Genomic DNA No translation available.
AC185507 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39459.1 [D3YWQ0-1]
CCDS85032.1 [D3YWQ0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001074675.1, NM_001081206.1 [D3YWQ0-1]
NP_001334033.1, NM_001347104.1 [D3YWQ0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000090314; ENSMUSP00000087788; ENSMUSG00000038665 [D3YWQ0-2]
ENSMUST00000101532; ENSMUSP00000099071; ENSMUSG00000038665 [D3YWQ0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
320127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:320127

UCSC genome browser

More...
UCSCi
uc009bjb.1, mouse [D3YWQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114574 Genomic DNA No translation available.
AC154019 Genomic DNA No translation available.
AC159480 Genomic DNA No translation available.
AC184160 Genomic DNA No translation available.
AC185507 Genomic DNA No translation available.
CCDSiCCDS39459.1 [D3YWQ0-1]
CCDS85032.1 [D3YWQ0-2]
RefSeqiNP_001074675.1, NM_001081206.1 [D3YWQ0-1]
NP_001334033.1, NM_001347104.1 [D3YWQ0-2]

3D structure databases

SMRiD3YWQ0
ModBaseiSearch...

Protein-protein interaction databases

IntActiD3YWQ0, 1 interactor
STRINGi10090.ENSMUSP00000099071

PTM databases

iPTMnetiD3YWQ0
PhosphoSitePlusiD3YWQ0
SwissPalmiD3YWQ0

Proteomic databases

MaxQBiD3YWQ0
PaxDbiD3YWQ0
PeptideAtlasiD3YWQ0
PRIDEiD3YWQ0
ProteomicsDBi350765
361049 [D3YWQ0-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32299, 191 antibodies

The DNASU plasmid repository

More...
DNASUi
320127

Genome annotation databases

EnsembliENSMUST00000090314; ENSMUSP00000087788; ENSMUSG00000038665 [D3YWQ0-2]
ENSMUST00000101532; ENSMUSP00000099071; ENSMUSG00000038665 [D3YWQ0-1]
GeneIDi320127
KEGGimmu:320127
UCSCiuc009bjb.1, mouse [D3YWQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9162
MGIiMGI:2443430, Dgki
VEuPathDBiHostDB:ENSMUSG00000038665

Phylogenomic databases

eggNOGiKOG0782, Eukaryota
GeneTreeiENSGT00940000158094
InParanoidiD3YWQ0
OMAiTREPAMD
OrthoDBi274339at2759
PhylomeDBiD3YWQ0
TreeFamiTF312817

Enzyme and pathway databases

UniPathwayiUPA00230
ReactomeiR-MMU-114508, Effects of PIP2 hydrolysis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
320127, 4 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dgki, mouse
RNActiD3YWQ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038665, Expressed in cerebral cortex and 103 other tissues
ExpressionAtlasiD3YWQ0, baseline and differential
GenevisibleiD3YWQ0, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR017438, ATP-NAD_kinase_N
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00130, C1_1, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
SSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50146, DAGK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKI_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YWQ0
Secondary accession number(s): D3Z2W1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 2, 2020
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again