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Protein

Transcriptional activator MN1

Gene

Mn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity).By similarity3 Publications

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator MN1Curated
Gene namesi
Name:Mn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1261813 Mn1

Pathology & Biotechi

Disruption phenotypei

Lethality occurs at or shortly after birth, associated with cleft secondary palate (PubMed:15870292). Skulls at late embryonic stages show multiple abnormalities including complete loss of alisphenoid, squamosal and vomer bones, and poorly developed presphenoid and basisphenoid bones (PubMed:15870292). Other parts of the skeleton are not affected (PubMed:15870292). Early palate development is normal but later the palatal shelves fail to grow and elevate towards the midline, associated with both impaired cell division and apoptosis (PubMed:18948418).2 Publications

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004353381 – 1297Transcriptional activator MN1Add BLAST1297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei932PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei988PhosphoserineBy similarity1
Modified residuei1062PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiD3YWE6
PRIDEiD3YWE6

PTM databases

iPTMnetiD3YWE6
PhosphoSitePlusiD3YWE6

Expressioni

Tissue specificityi

Detected in brain, heart, tibia, and calvarial osteoclasts.1 Publication

Developmental stagei

Detected in the midbrain, hindbrain and craniofacial mesenchyme at E9.5. At E10.5 and E11.5, strong expression is detected in the brain, frontonasal processes, maxillary processes, mandibular processes, the second brachial arch, and also in somites and limb buds. In the developing palatal shelves from E12.5-E14.5, shows graded expression with highest levels in the posterior and middle regions and very low levels in the anterior region.1 Publication

Inductioni

By calcitrol (1,25-dihydroxyvitamin D3).1 Publication

Gene expression databases

BgeeiENSMUSG00000070576 Expressed in 214 organ(s), highest expression level in ganglionic eminence
GenevisibleiD3YWE6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092034

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 144Gly/His-richPROSITE-ProRule annotationAdd BLAST74
Compositional biasi292 – 506Pro-richPROSITE-ProRule annotationAdd BLAST215
Compositional biasi509 – 564Gln-richPROSITE-ProRule annotationAdd BLAST56
Compositional biasi620 – 775Pro-richPROSITE-ProRule annotationAdd BLAST156

Phylogenomic databases

eggNOGiENOG410IEWX Eukaryota
ENOG410YZ22 LUCA
GeneTreeiENSGT00390000001777
HOGENOMiHOG000088640
InParanoidiD3YWE6
KOiK22543
OMAiRHPLMQP
OrthoDBiEOG091G01PB
PhylomeDBiD3YWE6
TreeFamiTF331780

Family and domain databases

InterProiView protein in InterPro
IPR037644 MN1
PANTHERiPTHR15821 PTHR15821, 1 hit

Sequencei

Sequence statusi: Complete.

D3YWE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGLDQFEPQ INSRHAGQGE GNFNEAGLSM NAHFKAPAFH AGPPTGPVDP
60 70 80 90 100
AISALGEPPI LGLNMEPYGF HARSHSELHA GGLQAQPVHG FFGGQQPHHS
110 120 130 140 150
HPGGHHPHQH HPHFGGNFGG PDPGASCLHG GRLLGYGGAA GGLGSQPPFA
160 170 180 190 200
ESYEHMAESQ GPEGFGPQRP GNLPDFHSSG TSGHAVPAPC LPLDQSPNRA
210 220 230 240 250
ASFHGLSASS GSDSHSLEPR RVTNQGAVDS LEYNYPSEPP SGHFDMFSPS
260 270 280 290 300
DSEGQLPHYA AGRQVPGGAF PGASAMPRAS GMVGLSKMHS QPPQPPPQQQ
310 320 330 340 350
QPQHGVFFER FGGARKMPVG LEPAVGSRHP LMQPPQQAPP PPQQPPPQQQ
360 370 380 390 400
PPPPGLLVRQ NSCPPALPRP QQGEAGTPSG GLQDGGPMLP SQHAQFEYPI
410 420 430 440 450
HRLENRSMHP YSEPVFSMQH PPPQQAPNQR LQHFDAPPYM NVAKRPRFDF
460 470 480 490 500
PGSAGVDRCA SWNGSMHNGT LDNQLSPSAY PGLPGEFTPP VPDSFSSGPP
510 520 530 540 550
LQHPGPDHQS LQQQQQQQQQ QQQQQQQQQQ QQQQQQQRQN AALMIKQMAS
560 570 580 590 600
RNQQQRLRQP NLAQLGHPGD VGQGGLVHGG SVGGLAQTNF EREGGSAGAG
610 620 630 640 650
RLSGFEQQAP HLAQESAWFP GPHPPGDLLP RRMGGAGLPT DCGPHDPALA
660 670 680 690 700
PPPAPGGSGV LFRGSLQEPL RMPGEGHVPA LASPGLQFGG SLAGLGQLQS
710 720 730 740 750
PGAGVGLPNA PSERRPPPPD FPAPALGGQP GFPFGSGSRQ ATPHSAPGVN
760 770 780 790 800
SPPSAGSGSS GAGGGAYPPQ PDFQPSQRNS ASKLGALSLG SFNKPSSKDN
810 820 830 840 850
LFGQSCLAAL STACQNMIAS LGAPNLNVTF NKKNPPEGKR KLSQNEPDSA
860 870 880 890 900
VAAGNPGSDY FPGGTTPGAP GPGGPSGTSG GGSKASGPPN PPIQGDSTSL
910 920 930 940 950
SPNYTLESTS GNDGKPVPGG SGRGRGRRKR DSGHVSPGTF FDKYSTAPDS
960 970 980 990 1000
GGAPGVSPGQ QQAPGSAAGG SSVNEARGPT PHEKALTSPS WGKGAELLLG
1010 1020 1030 1040 1050
DQPDLMASLD STAKSDGSSP HVGEFASDEV STSYANEDEV SSSSDNTTAL
1060 1070 1080 1090 1100
AKASRSPLVT SSPKLPPRGV GAGEHTPKAS ALGLGILSTS TSTPDSYGGG
1110 1120 1130 1140 1150
VGTGHPGTPG LEQVRTPTSS SGAQPPDEIH PLEILQAQIQ LQRQQFSISE
1160 1170 1180 1190 1200
DQPLGLKGSK KAECAVGASG AQNGDSELGS CCSEAVKSAM STIDLDSLMA
1210 1220 1230 1240 1250
EHSTTWYMPP DKALVDGGDE DKTLAPWEKA KSQNPNNKEA HDHPTNKASA
1260 1270 1280 1290
TQPGSHLQCL TVHCTDGDPK ARTSVPTWRS LHSDISNRFG TFVAALT
Length:1,297
Mass (Da):134,072
Last modified:April 20, 2010 - v1
Checksum:i41130654703FF053
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122226 Genomic DNA No translation available.
AC124749 Genomic DNA No translation available.
CCDSiCCDS39214.1
RefSeqiNP_001074704.1, NM_001081235.1
UniGeneiMm.332576

Genome annotation databases

EnsembliENSMUST00000094463; ENSMUSP00000092034; ENSMUSG00000070576
GeneIDi433938
KEGGimmu:433938
UCSCiuc008yse.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122226 Genomic DNA No translation available.
AC124749 Genomic DNA No translation available.
CCDSiCCDS39214.1
RefSeqiNP_001074704.1, NM_001081235.1
UniGeneiMm.332576

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092034

PTM databases

iPTMnetiD3YWE6
PhosphoSitePlusiD3YWE6

Proteomic databases

PaxDbiD3YWE6
PRIDEiD3YWE6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094463; ENSMUSP00000092034; ENSMUSG00000070576
GeneIDi433938
KEGGimmu:433938
UCSCiuc008yse.1 mouse

Organism-specific databases

CTDi4330
MGIiMGI:1261813 Mn1

Phylogenomic databases

eggNOGiENOG410IEWX Eukaryota
ENOG410YZ22 LUCA
GeneTreeiENSGT00390000001777
HOGENOMiHOG000088640
InParanoidiD3YWE6
KOiK22543
OMAiRHPLMQP
OrthoDBiEOG091G01PB
PhylomeDBiD3YWE6
TreeFamiTF331780

Miscellaneous databases

PROiPR:D3YWE6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070576 Expressed in 214 organ(s), highest expression level in ganglionic eminence
GenevisibleiD3YWE6 MM

Family and domain databases

InterProiView protein in InterPro
IPR037644 MN1
PANTHERiPTHR15821 PTHR15821, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMN1_MOUSE
AccessioniPrimary (citable) accession number: D3YWE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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