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Protein

Transcriptional activator MN1

Gene

Mn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • intramembranous ossification Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator MN1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mn1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1261813 Mn1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethality occurs at or shortly after birth, associated with cleft secondary palate (PubMed:15870292). Skulls at late embryonic stages show multiple abnormalities including complete loss of alisphenoid, squamosal and vomer bones, and poorly developed presphenoid and basisphenoid bones (PubMed:15870292). Other parts of the skeleton are not affected (PubMed:15870292). Early palate development is normal but later the palatal shelves fail to grow and elevate towards the midline, associated with both impaired cell division and apoptosis (PubMed:18948418).2 Publications

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004353381 – 1297Transcriptional activator MN1Add BLAST1297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei932PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei988PhosphoserineBy similarity1
Modified residuei1062PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3YWE6

PRoteomics IDEntifications database

More...
PRIDEi
D3YWE6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3YWE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3YWE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, heart, tibia, and calvarial osteoclasts.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the midbrain, hindbrain and craniofacial mesenchyme at E9.5. At E10.5 and E11.5, strong expression is detected in the brain, frontonasal processes, maxillary processes, mandibular processes, the second brachial arch, and also in somites and limb buds. In the developing palatal shelves from E12.5-E14.5, shows graded expression with highest levels in the posterior and middle regions and very low levels in the anterior region.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By calcitrol (1,25-dihydroxyvitamin D3).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000070576 Expressed in 214 organ(s), highest expression level in ganglionic eminence

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YWE6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000092034

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 144Gly/His-richPROSITE-ProRule annotationAdd BLAST74
Compositional biasi292 – 506Pro-richPROSITE-ProRule annotationAdd BLAST215
Compositional biasi509 – 564Gln-richPROSITE-ProRule annotationAdd BLAST56
Compositional biasi620 – 775Pro-richPROSITE-ProRule annotationAdd BLAST156

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEWX Eukaryota
ENOG410YZ22 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001777

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088640

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3YWE6

KEGG Orthology (KO)

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KOi
K22543

Identification of Orthologs from Complete Genome Data

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OMAi
ASWNGSM

Database of Orthologous Groups

More...
OrthoDBi
923694at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3YWE6

TreeFam database of animal gene trees

More...
TreeFami
TF331780

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037644 MN1

The PANTHER Classification System

More...
PANTHERi
PTHR15821 PTHR15821, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3YWE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGLDQFEPQ INSRHAGQGE GNFNEAGLSM NAHFKAPAFH AGPPTGPVDP
60 70 80 90 100
AISALGEPPI LGLNMEPYGF HARSHSELHA GGLQAQPVHG FFGGQQPHHS
110 120 130 140 150
HPGGHHPHQH HPHFGGNFGG PDPGASCLHG GRLLGYGGAA GGLGSQPPFA
160 170 180 190 200
ESYEHMAESQ GPEGFGPQRP GNLPDFHSSG TSGHAVPAPC LPLDQSPNRA
210 220 230 240 250
ASFHGLSASS GSDSHSLEPR RVTNQGAVDS LEYNYPSEPP SGHFDMFSPS
260 270 280 290 300
DSEGQLPHYA AGRQVPGGAF PGASAMPRAS GMVGLSKMHS QPPQPPPQQQ
310 320 330 340 350
QPQHGVFFER FGGARKMPVG LEPAVGSRHP LMQPPQQAPP PPQQPPPQQQ
360 370 380 390 400
PPPPGLLVRQ NSCPPALPRP QQGEAGTPSG GLQDGGPMLP SQHAQFEYPI
410 420 430 440 450
HRLENRSMHP YSEPVFSMQH PPPQQAPNQR LQHFDAPPYM NVAKRPRFDF
460 470 480 490 500
PGSAGVDRCA SWNGSMHNGT LDNQLSPSAY PGLPGEFTPP VPDSFSSGPP
510 520 530 540 550
LQHPGPDHQS LQQQQQQQQQ QQQQQQQQQQ QQQQQQQRQN AALMIKQMAS
560 570 580 590 600
RNQQQRLRQP NLAQLGHPGD VGQGGLVHGG SVGGLAQTNF EREGGSAGAG
610 620 630 640 650
RLSGFEQQAP HLAQESAWFP GPHPPGDLLP RRMGGAGLPT DCGPHDPALA
660 670 680 690 700
PPPAPGGSGV LFRGSLQEPL RMPGEGHVPA LASPGLQFGG SLAGLGQLQS
710 720 730 740 750
PGAGVGLPNA PSERRPPPPD FPAPALGGQP GFPFGSGSRQ ATPHSAPGVN
760 770 780 790 800
SPPSAGSGSS GAGGGAYPPQ PDFQPSQRNS ASKLGALSLG SFNKPSSKDN
810 820 830 840 850
LFGQSCLAAL STACQNMIAS LGAPNLNVTF NKKNPPEGKR KLSQNEPDSA
860 870 880 890 900
VAAGNPGSDY FPGGTTPGAP GPGGPSGTSG GGSKASGPPN PPIQGDSTSL
910 920 930 940 950
SPNYTLESTS GNDGKPVPGG SGRGRGRRKR DSGHVSPGTF FDKYSTAPDS
960 970 980 990 1000
GGAPGVSPGQ QQAPGSAAGG SSVNEARGPT PHEKALTSPS WGKGAELLLG
1010 1020 1030 1040 1050
DQPDLMASLD STAKSDGSSP HVGEFASDEV STSYANEDEV SSSSDNTTAL
1060 1070 1080 1090 1100
AKASRSPLVT SSPKLPPRGV GAGEHTPKAS ALGLGILSTS TSTPDSYGGG
1110 1120 1130 1140 1150
VGTGHPGTPG LEQVRTPTSS SGAQPPDEIH PLEILQAQIQ LQRQQFSISE
1160 1170 1180 1190 1200
DQPLGLKGSK KAECAVGASG AQNGDSELGS CCSEAVKSAM STIDLDSLMA
1210 1220 1230 1240 1250
EHSTTWYMPP DKALVDGGDE DKTLAPWEKA KSQNPNNKEA HDHPTNKASA
1260 1270 1280 1290
TQPGSHLQCL TVHCTDGDPK ARTSVPTWRS LHSDISNRFG TFVAALT
Length:1,297
Mass (Da):134,072
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41130654703FF053
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122226 Genomic DNA No translation available.
AC124749 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS39214.1

NCBI Reference Sequences

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RefSeqi
NP_001074704.1, NM_001081235.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.332576

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000094463; ENSMUSP00000092034; ENSMUSG00000070576

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
433938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:433938

UCSC genome browser

More...
UCSCi
uc008yse.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122226 Genomic DNA No translation available.
AC124749 Genomic DNA No translation available.
CCDSiCCDS39214.1
RefSeqiNP_001074704.1, NM_001081235.1
UniGeneiMm.332576

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092034

PTM databases

iPTMnetiD3YWE6
PhosphoSitePlusiD3YWE6

Proteomic databases

PaxDbiD3YWE6
PRIDEiD3YWE6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094463; ENSMUSP00000092034; ENSMUSG00000070576
GeneIDi433938
KEGGimmu:433938
UCSCiuc008yse.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4330
MGIiMGI:1261813 Mn1

Phylogenomic databases

eggNOGiENOG410IEWX Eukaryota
ENOG410YZ22 LUCA
GeneTreeiENSGT00390000001777
HOGENOMiHOG000088640
InParanoidiD3YWE6
KOiK22543
OMAiASWNGSM
OrthoDBi923694at2759
PhylomeDBiD3YWE6
TreeFamiTF331780

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3YWE6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000070576 Expressed in 214 organ(s), highest expression level in ganglionic eminence
GenevisibleiD3YWE6 MM

Family and domain databases

InterProiView protein in InterPro
IPR037644 MN1
PANTHERiPTHR15821 PTHR15821, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMN1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YWE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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