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Protein
Submitted name:

Collagen, type VI, alpha 3

Gene

Col6a3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • growth plate cartilage chondrocyte morphogenesis Source: GO_Central

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type VI, alpha 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col6a3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88461 Col6a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305234426 – 1703Sequence analysisAdd BLAST1678

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3YWD1

PRoteomics IDEntifications database

More...
PRIDEi
D3YWD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048126 Expressed in 240 organ(s), highest expression level in zone of skin

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3YWD1 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
D3YWD1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YWD1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 212VWFAInterPro annotationAdd BLAST175
Domaini241 – 414VWFAInterPro annotationAdd BLAST174
Domaini444 – 619VWFAInterPro annotationAdd BLAST176
Domaini638 – 811VWFAInterPro annotationAdd BLAST174
Domaini836 – 1008VWFAInterPro annotationAdd BLAST173
Domaini1026 – 1202VWFAInterPro annotationAdd BLAST177
Domaini1230 – 1401VWFAInterPro annotationAdd BLAST172
Domaini1433 – 1606VWFAInterPro annotationAdd BLAST174
Domaini1636 – 1703VWFAInterPro annotationAdd BLAST68

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156462

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168250

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00092 VWA, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327 VWA, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

D3YWD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKHRHLPLV AVFSLLLSGI ATTHAQQHGD VKNGAAADIV FLVDSSWSAG
60 70 80 90 100
KDRFLLVQEF LSDVVESLAV GDNDFHFALV RLNGNPHTEF LLNTYHSKQE
110 120 130 140 150
VLSHIVNMSY IGGSNQTGKG LEYVIHSHLT EASGSRAADG VPQVIIVLTD
160 170 180 190 200
GQSEDGFALP SAELKSADVN VFAVGVEGAD ERALGEVASE PLSMHVFNLE
210 220 230 240 250
NVTSLHGLVG NLVSCIHSSV NPERAGDKES LKDITAQDSA DIIFLIDGSQ
260 270 280 290 300
NTGNANFDVI RDFLVNVLER LSVGNQQVQV GVVQYSEEPI TMFSLNSYPS
310 320 330 340 350
KAAVLDAVKG LSLVGGESAN IGQALDFVVE NHFTRAGGSR VEEGVPQVLV
360 370 380 390 400
LISAGPSSDE IRDSVVALKQ ASVFSFGLGA QAASRAELQH IATDDSLVFT
410 420 430 440 450
VPEFRSFGDL QEQILPYLVG VAQRHIVLQP PAIVTQVMEV NKRDIVFLVD
460 470 480 490 500
GSSSLGPSNF NAIRDFVTRV IQRLEIGQDL VQVSVAQYAD TVKPEFYLNS
510 520 530 540 550
YTNKRDAITA VRKMRALNGS ALYTGSSLDF VRNNLFTSSA GHRAAEGVPK
560 570 580 590 600
LLVLITGGKS LDEVSQPAQE LKRGSIMALA VGSKAADEDE LKEIAFDSSL
610 620 630 640 650
VFIPAEFRPA PLQNMLPSLM APLRTLTGTT EVHVNKRDII FLLDGSDNVG
660 670 680 690 700
KNNFPYVRDF VTNLVNSLDV GSDNIRVGLV QFSDTPVTEF SLDTYQTKSE
710 720 730 740 750
LLAHLRRLQL KGGSGLNAGS ALSYIHANHF TEAGGSRTRE HVPQLLLLLM
760 770 780 790 800
AGPSEDAYLQ AANALVRSGV LTFCVGTNRA DKAELEHIAF NPSLVYLMDD
810 820 830 840 850
FRSLPSLPQQ LIQPLTTYVS GGVQEVPLSQ PESKRDILFL FDGSVNVLGQ
860 870 880 890 900
FPAVRDFLYR IIEELDVKPD GTRVAIAQFS DDVRLESRFS EHQTKAEILN
910 920 930 940 950
LVKKMKLKTG KALNLGYALD YALRNIFVRS AGSRIEDNVQ QFLVLLVAGR
960 970 980 990 1000
SSDAVAGPAS SLKQRGVVPF IFQAKNANPS ELEQIVLSPA FILAAESLPK
1010 1020 1030 1040 1050
IGDLQSQIVS LLKAEQGSGP VSGEKDVVFL IDGSEGVRSG FPLLKDFVQR
1060 1070 1080 1090 1100
VVESLDVGPD RVRVALVQYS DRTRPEFYLN SHMDQQGVIS AIRRLTLLGG
1110 1120 1130 1140 1150
PTPNTGAALE FVLRNILTSS TGSRIAEGVP QLLIVLTAEP SGDDVRGPSV
1160 1170 1180 1190 1200
VLKQGGAVPI GIGIGNADIS EMQTISFIPD FAVAIPTFRE LGTIQQVISE
1210 1220 1230 1240 1250
RVIQLNREEL SSLKPILTPS TGAGVGSKKD VVFLIDGSRN AGPEFQYIRT
1260 1270 1280 1290 1300
LIERIVEYLD IGFDTTRVAV IQFSEDSKME FPLNAHFSKD EVQNAVRRLR
1310 1320 1330 1340 1350
PKGGSQVYIG NALEYVLKNI FQRPLGSRIE EGVPQFLVLI SSGKSDDEVD
1360 1370 1380 1390 1400
DSAVELKQFG VAPLTIARHT DQEELVKISL SPEYVYSVST FRELPRLEQK
1410 1420 1430 1440 1450
LLTPITTLTS QQIHQILAST RYPPSVVESD AADIVFLIDS SDAVKPDGIA
1460 1470 1480 1490 1500
HIRDFVSRIV RRLNIGPSKV RIGVVQFSND VFPEFYLKTH KSQSSVLEAI
1510 1520 1530 1540 1550
RRLRFKGGSP LNTGRALEFV ARNLFVKSAG SRIEDGVPQH LVLFLGGKSQ
1560 1570 1580 1590 1600
DDVARHAQVI SSSGIVSLGI GDRNIDRTDL QTITNDPRLV FTVREFRELP
1610 1620 1630 1640 1650
NIEERVMLSF GPSGATPQPP GVDLPSPSRP EKKKADIVFL LDGSINFRRD
1660 1670 1680 1690 1700
SFQEVLRFAS EIVDTVYEDG DSIRVGLVQY NSDPTDEFFL RDFSTKRQII

DAI
Length:1,703
Mass (Da):185,729
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB12CA8944C16FB66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWQ3E9PWQ3_MOUSE
Collagen, type VI, alpha 3
Col6a3
3,284Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQ16J3QQ16_MOUSE
Collagen, type VI, alpha 3
Col6a3
2,677Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WS16A0A087WS16_MOUSE
Collagen, type VI, alpha 3
Col6a3
2,677Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQN9A0A087WQN9_MOUSE
Collagen, type VI, alpha 3
Col6a3
74Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1703Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC110895 Genomic DNA No translation available.
AC158773 Genomic DNA No translation available.
FQ976558 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000130846; ENSMUSP00000115210; ENSMUSG00000048126

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110895 Genomic DNA No translation available.
AC158773 Genomic DNA No translation available.
FQ976558 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD3YWD1
SMRiD3YWD1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiD3YWD1
PRIDEiD3YWD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130846; ENSMUSP00000115210; ENSMUSG00000048126

Organism-specific databases

MGIiMGI:88461 Col6a3

Phylogenomic databases

GeneTreeiENSGT00940000156462
HOGENOMiHOG000168250

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048126 Expressed in 240 organ(s), highest expression level in zone of skin
ExpressionAtlasiD3YWD1 baseline and differential

Family and domain databases

Gene3Di3.40.50.410, 9 hits
InterProiView protein in InterPro
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00092 VWA, 9 hits
SMARTiView protein in SMART
SM00327 VWA, 8 hits
SUPFAMiSSF53300 SSF53300, 9 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YWD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YWD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: October 3, 2012
Last modified: December 5, 2018
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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