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Entry version 72 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Tubulin polyglutamylase TTLL5

Gene

Ttll5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tubulin polyglutamylase TTLL5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttll5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443657, Ttll5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000012609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
D3YVZ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3YVZ5

PRoteomics IDEntifications database

More...
PRIDEi
D3YVZ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
310464

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000012609, Expressed in spermatocyte and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3YVZ5, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YVZ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni411 – 436DisorderedSequence analysisAdd BLAST26
Regioni572 – 618DisorderedSequence analysisAdd BLAST47
Regioni821 – 840DisorderedSequence analysisAdd BLAST20
Regioni935 – 962DisorderedSequence analysisAdd BLAST28
Regioni992 – 1018DisorderedSequence analysisAdd BLAST27
Regioni1071 – 1115DisorderedSequence analysisAdd BLAST45
Regioni1198 – 1281DisorderedSequence analysisAdd BLAST84

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili759 – 781Sequence analysisAdd BLAST23
Coiled coili1153 – 1173Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi411 – 431Polar residuesSequence analysisAdd BLAST21
Compositional biasi582 – 604Acidic residuesSequence analysisAdd BLAST23
Compositional biasi821 – 836Polar residuesSequence analysisAdd BLAST16
Compositional biasi947 – 962Polar residuesSequence analysisAdd BLAST16
Compositional biasi1071 – 1112Polar residuesSequence analysisAdd BLAST42

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162910

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006704_1_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004344, TTL/TTLL_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133, TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221, TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

D3YVZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVVMARDLE ETASSSEDED LANQEDHPCI MWTGGCRRIP VLVFHAEAIL
60 70 80 90 100
TKDNNIRVIG ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW
110 120 130 140 150
TGSHLKPFLL RTLSEAQKVN HFPRSYELTR KDRLYKNIIR MQHTHGFKAF
160 170 180 190 200
HILPQTFLLP AEYAEFCNSY SKDRGPWIVK PVASSRGRGV YLINNPNQIS
210 220 230 240 250
LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL YEEGLARFAT
260 270 280 290 300
VRYDQGSKNI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML
310 320 330 340 350
RYLKQEGKDT TALMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY
360 370 380 390 400
GFDVLIDNTL KPWLLEVNLS PSLACDAPLD LKIKASMISD MFTVVGFVCQ
410 420 430 440 450
DPAQRTSNRS IYPSFESSRR NPFQKPQRTR PLSASDAEMK NLVASAREKV
460 470 480 490 500
PGKLGGSVLG LSMEEIKVLR RVKEENDRRG GFIRIFPTSE TWEIYGSYLE
510 520 530 540 550
HKTSMNYMLA TRLFQDRVST EGAPELKVES MNSKAKLHAA LYERKLLSLE
560 570 580 590 600
VRKRRRRSGR LRAMRPKYPV IAQPAEMNIK TETESEEEEE VGLDNDDEEQ
610 620 630 640 650
EASQEESAGS LGENQAKYTP SLTVIVENSP RDNAMKVAEW TNKGEPCCKI
660 670 680 690 700
EAQEPESKFN LMQILQDNGN LSKVQARLAF SAYLQHVQIR LTKDSGGQTL
710 720 730 740 750
SPSWAAKEDE QMELVVRFLK RASSNLQHSL RMVLPSRRLA LLERRRILAH
760 770 780 790 800
QLGDFIGVYN KETEQMAEKK SKKKLEEEEE DGVNAESFQE FIRQASEAEL
810 820 830 840 850
EEVLTFYTQK NKSASVFLGT HSKSSKNSSS YSDSGAKGDH PETIQEVKIK
860 870 880 890 900
QPKQQQATEI HADKLSRFTT SSGKEAKLVY TNCSSFCSPA AVLLQRLPSS
910 920 930 940 950
HLSSVITTSA LSAGPGHHAS LSQIPPAVPS LPHQPALLLS PVPDNAPPSI
960 970 980 990 1000
HSGTQNVSPA GLPRCRSGSY TIGPFSSFQS AAHIYSQKLS RPSSAKAGSC
1010 1020 1030 1040 1050
HPHKHHSGIA KTQKEGEDVS LNRRYNQSLV TAELQRLAEK QAARQYSPAS
1060 1070 1080 1090 1100
HISLLTQQVT NLNLASSVIN RSSASTPPTL RPVISPSGPT WSIQPDLHAS
1110 1120 1130 1140 1150
ETHSSPPGSR SLQTGGFAWE GEVENNAYSK TTGVVPQHKY HPTAGSYQLH
1160 1170 1180 1190 1200
FALQQLEQQK LQSRQLLDQS RARHQAIFGS QTLPNSSLWT MNNGPGCRIS
1210 1220 1230 1240 1250
SATTGGQKPN TLPQKVVAPP NSSTLVSKPA SNHKQVLRKP ASQRASKGSS
1260 1270 1280
AEGQLNGLQS SLNPAAFMPI TNSTDPAHTN R
Length:1,281
Mass (Da):142,908
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6674DDEE909B3B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CHB8TTLL5_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5 Kiaa0998
1,328Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q425E9Q425_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
1,295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJ73H3BJ73_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
795Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK74H3BK74_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLA3H3BLA3_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLC0H3BLC0_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJC7H3BJC7_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BUF0Q8BUF0_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJC2H3BJC2_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C125Q8C125_MOUSE
Tubulin polyglutamylase TTLL5
Ttll5
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110224; ENSMUSP00000105853; ENSMUSG00000012609

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiD3YVZ5
ModBaseiSearch...

Proteomic databases

EPDiD3YVZ5
MaxQBiD3YVZ5
PRIDEiD3YVZ5
ProteomicsDBi310464

Genome annotation databases

EnsembliENSMUST00000110224; ENSMUSP00000105853; ENSMUSG00000012609

Organism-specific databases

MGIiMGI:2443657, Ttll5
VEuPathDBiHostDB:ENSMUSG00000012609

Phylogenomic databases

GeneTreeiENSGT00940000162910
HOGENOMiCLU_006704_1_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ttll5, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000012609, Expressed in spermatocyte and 251 other tissues
ExpressionAtlasiD3YVZ5, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004344, TTL/TTLL_fam
PfamiView protein in Pfam
PF03133, TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221, TTL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YVZ5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YVZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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