UniProtKB - D3YVY7 (D3YVY7_MOUSE)
Protein
Hyaluronidase
Gene
Hyal3
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.UniRule annotationARBA annotation EC:3.2.1.35
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 129 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- hyalurononglucosaminidase activity Source: UniProtKB-UniRule
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- hyaluronan catabolic process Source: InterPro
- single fertilization Source: UniProtKB-KW
Keywordsi
Molecular function | GlycosidaseUniRule annotationARBA annotation, Hydrolase |
Biological process | FertilizationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Hyal3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1330288, Hyal3 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum ARBA annotation
Endosome
- Early endosome ARBA annotation
- Endosome ARBA annotation
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Endosome
- early endosome Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- acrosomal vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesicleARBA annotation, Endoplasmic reticulumARBA annotation, EndosomeARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5003052943 | 25 – 328 | HyaluronidaseSequence analysisAdd BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 206 ↔ 221 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationProteomic databases
ProteomicsDBi | 349610 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036091, Expressed in respiratory system and 69 other tissues |
ExpressionAtlasi | D3YVY7, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT01020000230364 |
HOGENOMi | CLU_036366_2_0_1 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR017853, Glycoside_hydrolase_SF IPR018155, Hyaluronidase IPR027260, Hyaluronidase-3 |
PANTHERi | PTHR11769, PTHR11769, 2 hits PTHR11769:SF19, PTHR11769:SF19, 2 hits |
Pfami | View protein in Pfam PF01630, Glyco_hydro_56, 1 hit |
PIRSFi | PIRSF038193, Hyaluronidase, 2 hits |
PRINTSi | PR00846, GLHYDRLASE56 |
SUPFAMi | SSF51445, SSF51445, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3YVY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIMHLGLMMV VGLTLCLMHG QALLQVPEHP FSVVWNVPSA RCKAHFGVHL
60 70 80 90 100
PLDALGIVAN HGQHFHGQNI SIFYKNQFGL YPYFGPRGTA HNGGIPQAVS
110 120 130 140 150
LDHHLARAAH QILHSLGSSF AGLAVLDWEE WYPLWAGNWG PHRQVYLAAS
160 170 180 190 200
WVWTQQMFPG LDPQEQLHKA HTSFEQAARA LMEYTLQLGR TLRPSGLWGF
210 220 230 240 250
YRYPACGNGW HKMASNYTGH CHAAITTRNT QLRWLWAASS ALFPSIYLPP
260 270 280 290 300
RLPLAYRQAF VRHRLEEAFR VALLEHSHPL PVLAYSRLTH RSSGRFLSLE
310 320
KCWRLHDYLV GTLGPYVINV TKAAMACS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8VEI3 | HYAL3_MOUSE | Hyaluronidase-3 | Hyal3 Hyl3 | 412 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 328 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672219 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000149487; ENSMUSP00000117845; ENSMUSG00000036091 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672219 Genomic DNA No translation available. |
3D structure databases
SMRi | D3YVY7 |
ModBasei | Search... |
Proteomic databases
ProteomicsDBi | 349610 |
Protocols and materials databases
Antibodypediai | 34877, 188 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000149487; ENSMUSP00000117845; ENSMUSG00000036091 |
Organism-specific databases
MGIi | MGI:1330288, Hyal3 |
Phylogenomic databases
GeneTreei | ENSGT01020000230364 |
HOGENOMi | CLU_036366_2_0_1 |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036091, Expressed in respiratory system and 69 other tissues |
ExpressionAtlasi | D3YVY7, baseline and differential |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR017853, Glycoside_hydrolase_SF IPR018155, Hyaluronidase IPR027260, Hyaluronidase-3 |
PANTHERi | PTHR11769, PTHR11769, 2 hits PTHR11769:SF19, PTHR11769:SF19, 2 hits |
Pfami | View protein in Pfam PF01630, Glyco_hydro_56, 1 hit |
PIRSFi | PIRSF038193, Hyaluronidase, 2 hits |
PRINTSi | PR00846, GLHYDRLASE56 |
SUPFAMi | SSF51445, SSF51445, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3YVY7_MOUSE | |
Accessioni | D3YVY7Primary (citable) accession number: D3YVY7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | April 7, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |