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Protein

Anion exchange protein

Gene

Slc4a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • inorganic anion exchanger activity Source: InterPro
  • sodium:bicarbonate symporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-425381 Bicarbonate transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
Gene namesi
Name:Slc4a5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2443220 Slc4a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei399 – 421HelicalUniRule annotationAdd BLAST23
Transmembranei433 – 464HelicalUniRule annotationAdd BLAST32
Transmembranei484 – 505HelicalUniRule annotationAdd BLAST22
Transmembranei517 – 540HelicalUniRule annotationAdd BLAST24
Transmembranei620 – 638HelicalUniRule annotationAdd BLAST19
Transmembranei658 – 677HelicalUniRule annotationAdd BLAST20
Transmembranei706 – 724HelicalUniRule annotationAdd BLAST19
Transmembranei744 – 760HelicalUniRule annotationAdd BLAST17
Transmembranei806 – 825HelicalUniRule annotationAdd BLAST20
Transmembranei831 – 851HelicalUniRule annotationAdd BLAST21
Transmembranei901 – 918HelicalUniRule annotationAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiD3YVG0
PeptideAtlasiD3YVG0
PRIDEiD3YVG0

Expressioni

Gene expression databases

BgeeiENSMUSG00000068323 Expressed in 69 organ(s), highest expression level in camera-type eye
ExpressionAtlasiD3YVG0 baseline and differential
GenevisibleiD3YVG0 MM

Structurei

3D structure databases

ProteinModelPortaliD3YVG0
SMRiD3YVG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 292Band_3_cytoInterPro annotationAdd BLAST267
Domaini368 – 884HCO3_cotranspInterPro annotationAdd BLAST517

Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00760000119021
HOGENOMiHOG000280684
KOiK13857
OMAiKNPWWIY

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3YVG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTLQHDGDQ MEWKESARWI KFEEKVEEGG ERWSKPHVST LSLHSLFELR
60 70 80 90 100
TCLQTGTVLL DLDSCSLPQI IDDVIEKQIE DGLLRPELRE RVSYVLLRKH
110 120 130 140 150
RHQTKKPIHR SLADIGKSVS TTNRSSARSS SAGPTLHRST EDLRIRQSTS
160 170 180 190 200
YGHLCHAQSR SMNDISHTPN TDQRKNKFMK KIPKDSEASN VLVGEVDFLD
210 220 230 240 250
QPFIAFVRLV QSAMLGGVTE VPVPTRFLFI LLGPSGRAKS YNEIGRAIAT
260 270 280 290 300
LMVDDLFSDV AYKARNREDL IAGIDEFLDE VIVLPPGEWD PNIRIEPPKK
310 320 330 340 350
VPSADKRKSV FSLAEPGQMN GSVGGGGASA GGGGSGGGAG GSGAGGVGSG
360 370 380 390 400
DEAEMPAMHE IGEELIWTGR FFGGLCLDVK RKLPWFPSDF YDGFHLQSIS
410 420 430 440 450
AVLFIYLGCI TNAITFGGLL GDATDNYQGV MESFLGTAMA GSLFCLFSGQ
460 470 480 490 500
PLIILSSTGP ILIFEKLLFD FSKANGLDYM EFRLWIGLHS AIQCLILVAT
510 520 530 540 550
DASFIIKYIT RFTEEGFSTL ISFIFIYDAI KKMIGAFKYY PINTDFKPDF
560 570 580 590 600
ITTYKCECVA PDTVNTTTVN ASAPLAPNTN TSLYTPLNLT ALDWSLLSKK
610 620 630 640 650
ECLSYGGRLL GSSCQFVPDL ALMSFILFFG TYSMTLTLKK FKFSRYFPTK
660 670 680 690 700
VRTLVADFSI VFSILLFCGI DACFGLQTPK LHVPSVIKPT RPDRGWFVAP
710 720 730 740 750
FGKNPWWVYP ASILPALLVT ILIFMDQQIT AVIVNRKENK LRKAAGYHLD
760 770 780 790 800
LFWVGILMAL CSFTGLPWYV AATVISIAHI DSLKMETETS APGEQPQFLG
810 820 830 840 850
VREQRVTGVM VFILTGISVF LAPILKYIPM PVLYGVFLYM GVASLNGIQF
860 870 880 890 900
WERCKLFLMP AKHQPDHAFL RHVPLRRIHL FTLVQILCLA LLWILKSTMA
910 920 930 940 950
AIIFPVMILG LIIVRRLLDL IFSQHDLAWI DNILPEKDKK ETDKKKKRRK
960 970 980 990 1000
EVHETAEKEV AMPQFLPPSV VKIPMEGIPS DPQNGIHCVA RKRSSSWSYS

L
Length:1,001
Mass (Da):111,516
Last modified:April 5, 2011 - v2
Checksum:i3C75F2BD60AA80DF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3M5E9Q3M5_MOUSE
Anion exchange protein
Slc4a5
1,116Annotation score:
D3YX36D3YX36_MOUSE
Anion exchange protein
Slc4a5
1,041Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159713 Genomic DNA No translation available.
AC160400 Genomic DNA No translation available.
RefSeqiNP_001159539.1, NM_001166067.1
UniGeneiMm.333189

Genome annotation databases

EnsembliENSMUST00000039212; ENSMUSP00000041007; ENSMUSG00000068323
GeneIDi232156
KEGGimmu:232156
UCSCiuc012enx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159713 Genomic DNA No translation available.
AC160400 Genomic DNA No translation available.
RefSeqiNP_001159539.1, NM_001166067.1
UniGeneiMm.333189

3D structure databases

ProteinModelPortaliD3YVG0
SMRiD3YVG0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD3YVG0
PeptideAtlasiD3YVG0
PRIDEiD3YVG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039212; ENSMUSP00000041007; ENSMUSG00000068323
GeneIDi232156
KEGGimmu:232156
UCSCiuc012enx.1 mouse

Organism-specific databases

CTDi57835
MGIiMGI:2443220 Slc4a5

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00760000119021
HOGENOMiHOG000280684
KOiK13857
OMAiKNPWWIY

Enzyme and pathway databases

ReactomeiR-MMU-425381 Bicarbonate transporters

Miscellaneous databases

ChiTaRSiSlc4a5 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068323 Expressed in 69 organ(s), highest expression level in camera-type eye
ExpressionAtlasiD3YVG0 baseline and differential
GenevisibleiD3YVG0 MM

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3YVG0_MOUSE
AccessioniPrimary (citable) accession number: D3YVG0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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