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Protein

A-kinase anchor protein 5

Gene

Akap5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May anchor the PKA kinase to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-399719 Trafficking of AMPA receptors
R-MMU-9010642 ROBO receptors bind AKAP5

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 5
Short name:
AKAP-5
Alternative name(s):
A-kinase anchor protein 150 kDa
Short name:
AKAP 150
Short name:
P150
cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Gene namesi
Name:Akap5
Synonyms:Akap150
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2685104 Akap5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004147501 – 745A-kinase anchor protein 5Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Lipidationi36S-palmitoyl cysteineBy similarity1
Lipidationi123S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation at Cys-36 and Cys-123 plays a key role in targeting to lipid rafts.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiD3YVF0
PaxDbiD3YVF0
PeptideAtlasiD3YVF0
PRIDEiD3YVF0

PTM databases

iPTMnetiD3YVF0
PhosphoSitePlusiD3YVF0
SwissPalmiD3YVF0

Expressioni

Gene expression databases

BgeeiENSMUSG00000021057 Expressed in 200 organ(s), highest expression level in lung
ExpressionAtlasiD3YVF0 baseline and differential
GenevisibleiD3YVF0 MM

Interactioni

Subunit structurei

Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Binds dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231964, 3 interactors
ComplexPortaliCPX-1006 Calcineurin-Calmodulin-AKAP5 complex, beta-R1 variant
CPX-1113 Calcineurin-Calmodulin-AKAP5 complex, gamma-R1 variant
CPX-1115 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant
CPX-1117 Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant
CPX-1119 Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant
CPX-881 Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant
IntActiD3YVF0, 3 interactors
MINTiD3YVF0
STRINGi10090.ENSMUSP00000114495

Structurei

3D structure databases

ProteinModelPortaliD3YVF0
SMRiD3YVF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 100AKAPAdd BLAST30
Repeati304 – 3121; approximate9
Repeati320 – 3272; approximate8
Repeati328 – 3353; approximate8
Repeati348 – 3554; approximate8
Repeati356 – 3635; approximate8
Repeati364 – 3956; approximateAdd BLAST32
Repeati420 – 4367; approximateAdd BLAST17
Repeati445 – 4528; approximate8
Repeati461 – 46898
Repeati469 – 476108
Repeati477 – 484118
Repeati485 – 492128
Repeati493 – 500138
Repeati501 – 50814; approximate8
Repeati517 – 52415; approximate8
Repeati525 – 532168
Repeati533 – 540178
Repeati541 – 548188
Repeati549 – 556198
Repeati557 – 56420; approximate8
Repeati565 – 572218
Repeati573 – 58022; approximate8
Repeati581 – 58823; approximate8
Repeati589 – 59624; approximate8
Repeati597 – 604258
Repeati605 – 61226; approximate8
Repeati613 – 62027; approximate8
Repeati621 – 62828; approximate8

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 164Essential to the intracellular anchoring functionBy similarityAdd BLAST164
Regioni304 – 62828 X 8 AA repeats of V-G-Q-A-E-E-A-TAdd BLAST325
Regioni706 – 727RII-beta subunit binding domainBy similarityAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 654Glu-richAdd BLAST323

Domaini

The N-terminal region, which is highly basic, is required for interaction with calmodulin.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIWH Eukaryota
ENOG4111833 LUCA
GeneTreeiENSGT00390000019941
HOGENOMiHOG000168350
InParanoidiD3YVF0
KOiK16522
PhylomeDBiD3YVF0

Family and domain databases

InterProiView protein in InterPro
IPR001573 Pkinase-A_anch_WSK-motif
PfamiView protein in Pfam
PF03832 WSK, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3YVF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSVSEIQV ETKDEKGPVA ASPQKERQER KTATLCFKRR KKANKTKPKA
60 70 80 90 100
GSRTAEETKK HTPEAGGSGQ RQPAGAWASI KGLVTHRKRS EPAKKQKPPE
110 120 130 140 150
AEVQPEDGAL PKKKAKSRLK FPCLRFSRGA KRSRHSKLTE DSGYVRVQGE
160 170 180 190 200
ADDLEIKAQT QPDDQAIQAG STQGLQEGVL VRDGKKSQES HISNSVTSGE
210 220 230 240 250
NVIAIELELE NKSSAIQMGT PELEKETKVI TEKPSVQTQR ASLLESSAAG
260 270 280 290 300
SPRSVTSAAP PSPATTHQHS LEEPSNGIRE SAPSGKDDRR KTAAEEKKSG
310 320 330 340 350
ETALGQAEEA AVGQADKRAL SQAGEATAGH PEEATVIQAE SQAKEGKLSQ
360 370 380 390 400
AEETTVAQAK ETVLSQAKEG ELSQAKKATV GQAEEATIDH TEKVTVDQAE
410 420 430 440 450
ETTVGQAEEA TVGQAGEAIL SQAKEATVVG QAEEATVDRA EEATVGQAEE
460 470 480 490 500
ATVGHTEKVT VDQAEEATVG QAEEATVGQA EEATVDWAEK PTVGQAEEAT
510 520 530 540 550
VGQAEEATVG HTEKVTVDQA EEATVGQAEE ATVGHTEKVT VDHAEEATVG
560 570 580 590 600
QAEEATVGQA EKVTVDHAEE ATVGQAEEAT VGQAEKVTVD HAEEATVGQA
610 620 630 640 650
EEATVGQAEK VTVDQAEEPT VDQAEEAISS HAPDLKENGI DTEKPRSEES
660 670 680 690 700
KRMEPIAIII TDTEISEFDV KKSKNVPKQF LISMENEQVG VFANDSDFEG
710 720 730 740
RTSEQYETLL IETASSLVKN AIELSVEQLV NEMVSEDNQI NTLFQ
Length:745
Mass (Da):79,397
Last modified:April 5, 2011 - v2
Checksum:iB0A2949CC0F52569
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BIV5H3BIV5_MOUSE
A-kinase anchor protein 5
Akap5
752Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120002 Genomic DNA No translation available.
CCDSiCCDS49092.1
RefSeqiNP_001094941.1, NM_001101471.1
UniGeneiMm.311452

Genome annotation databases

EnsembliENSMUST00000154078; ENSMUSP00000114495; ENSMUSG00000021057
GeneIDi238276
KEGGimmu:238276
UCSCiuc007nya.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120002 Genomic DNA No translation available.
CCDSiCCDS49092.1
RefSeqiNP_001094941.1, NM_001101471.1
UniGeneiMm.311452

3D structure databases

ProteinModelPortaliD3YVF0
SMRiD3YVF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231964, 3 interactors
ComplexPortaliCPX-1006 Calcineurin-Calmodulin-AKAP5 complex, beta-R1 variant
CPX-1113 Calcineurin-Calmodulin-AKAP5 complex, gamma-R1 variant
CPX-1115 Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant
CPX-1117 Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant
CPX-1119 Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant
CPX-881 Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant
IntActiD3YVF0, 3 interactors
MINTiD3YVF0
STRINGi10090.ENSMUSP00000114495

PTM databases

iPTMnetiD3YVF0
PhosphoSitePlusiD3YVF0
SwissPalmiD3YVF0

Proteomic databases

MaxQBiD3YVF0
PaxDbiD3YVF0
PeptideAtlasiD3YVF0
PRIDEiD3YVF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154078; ENSMUSP00000114495; ENSMUSG00000021057
GeneIDi238276
KEGGimmu:238276
UCSCiuc007nya.2 mouse

Organism-specific databases

CTDi9495
MGIiMGI:2685104 Akap5

Phylogenomic databases

eggNOGiENOG410IIWH Eukaryota
ENOG4111833 LUCA
GeneTreeiENSGT00390000019941
HOGENOMiHOG000168350
InParanoidiD3YVF0
KOiK16522
PhylomeDBiD3YVF0

Enzyme and pathway databases

ReactomeiR-MMU-399719 Trafficking of AMPA receptors
R-MMU-9010642 ROBO receptors bind AKAP5

Miscellaneous databases

PROiPR:D3YVF0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021057 Expressed in 200 organ(s), highest expression level in lung
ExpressionAtlasiD3YVF0 baseline and differential
GenevisibleiD3YVF0 MM

Family and domain databases

InterProiView protein in InterPro
IPR001573 Pkinase-A_anch_WSK-motif
PfamiView protein in Pfam
PF03832 WSK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKAP5_MOUSE
AccessioniPrimary (citable) accession number: D3YVF0
Secondary accession number(s): D3Z5C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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