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Protein

Matrix metalloproteinase

Gene

Mmp27

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei258UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiM10.027

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:Mmp27Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3039232 Mmp27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, ZymogenUniRule annotation

Proteomic databases

PaxDbiD3YV89
PRIDEiD3YV89

PTM databases

iPTMnetiD3YV89
PhosphoSitePlusiD3YV89

Expressioni

Gene expression databases

BgeeiENSMUSG00000070323 Expressed in 12 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiD3YV89 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091423

Structurei

3D structure databases

ProteinModelPortaliD3YV89
SMRiD3YV89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati317 – 366HemopexinPROSITE-ProRule annotationAdd BLAST50
Repeati367 – 412HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati414 – 462HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati463 – 506HemopexinPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
OMAiPHACDPD
OrthoDBiEOG091G03DP
PhylomeDBiD3YV89
TreeFamiTF315428

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028732 MMP27
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF115 PTHR10201:SF115, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 3 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 2 hits
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

D3YV89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYKQKQALT EETGMKCLLS LMVNFITLSA AFPPDRKDKN EENNQLAQAY
60 70 80 90 100
LNQFYSLEIE GSHFVQSKNR SLFDGKLREM QAFFGLTVTG KLDSDTLAIM
110 120 130 140 150
KVPRCGVPDV GQYGYTLPGW RKYSLTYRIM NYTPDMTPAD VDEAIQKALQ
160 170 180 190 200
VWSKVTPLTF TRISKGVADI MIAFRTGGKA CSEGSDFFED HRELTYLPIN
210 220 230 240 250
CLSVHGWCPR HFDGPLGVLG HAFPPGLGLG GDTHFDEDET WIAKDGEGFN
260 270 280 290 300
LFLVAAHEFG HSLGLSHSND QTALMFPNYI SLDPSKYPLS QDDIDGIQSI
310 320 330 340 350
YGSPPKVTTK PSGNSEPHAC DPTLTFDAIT TFRREVMFFK GRHLWRVYSD
360 370 380 390 400
IAGAEFEFID SFWPSLPADL QAAYESPRDE LLVFKDENFW VIRGYSVLPG
410 420 430 440 450
YPKSIHTLGF PRRVKKIDAA VCDHDTRKTF FFVGIWCWRY DEMAQAMDRG
460 470 480 490 500
FPQRIIKCFP GIRLRVDAVF QHNGFLYFFH GSRQFEYDMK AKNITQVIKT
510 520 530 540 550
NSWFLCNEPL NASFNVSVKG KANSIGTVIL HHKRLSLLTF SIVHVLTKTY

N
Length:551
Mass (Da):62,544
Last modified:April 20, 2010 - v1
Checksum:iDCB1EB235899FD0A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6I1D3Z6I1_MOUSE
Matrix metalloproteinase
Mmp27
525Annotation score:
F6QKX8F6QKX8_MOUSE
Matrix metalloproteinase
Mmp27
470Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115689 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000151853; ENSMUSP00000117469; ENSMUSG00000070323
UCSCiuc009ocs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115689 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD3YV89
SMRiD3YV89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091423

Protein family/group databases

MEROPSiM10.027

PTM databases

iPTMnetiD3YV89
PhosphoSitePlusiD3YV89

Proteomic databases

PaxDbiD3YV89
PRIDEiD3YV89

Protocols and materials databases

DNASUi234911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000151853; ENSMUSP00000117469; ENSMUSG00000070323
UCSCiuc009ocs.1 mouse

Organism-specific databases

MGIiMGI:3039232 Mmp27

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
OMAiPHACDPD
OrthoDBiEOG091G03DP
PhylomeDBiD3YV89
TreeFamiTF315428

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070323 Expressed in 12 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiD3YV89 baseline and differential

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028732 MMP27
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF115 PTHR10201:SF115, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 3 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 2 hits
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiD3YV89_MOUSE
AccessioniPrimary (citable) accession number: D3YV89
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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