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Entry version 56 (16 Jan 2019)
Sequence version 1 (20 Apr 2010)
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Protein

Coiled-coil domain-containing protein 13

Gene

Ccdc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 13Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920144 Ccdc13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004319581 – 709Coiled-coil domain-containing protein 13Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3YV10

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3YV10

PeptideAtlas

More...
PeptideAtlasi
D3YV10

PRoteomics IDEntifications database

More...
PRIDEi
D3YV10

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3YV10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3YV10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079235 Expressed in 76 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3YV10 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YV10 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCM1, CEP290 and PCNT.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3YV10, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000114787

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YV10

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili70 – 97Sequence analysisAdd BLAST28
Coiled coili139 – 178Sequence analysisAdd BLAST40
Coiled coili206 – 288Sequence analysisAdd BLAST83
Coiled coili323 – 457Sequence analysisAdd BLAST135
Coiled coili539 – 604Sequence analysisAdd BLAST66

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGKT Eukaryota
ENOG410YWT6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111402

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3YV10

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFRMYHE

Database of Orthologous Groups

More...
OrthoDBi
1533296at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328506

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038929 CCDC13

The PANTHER Classification System

More...
PANTHERi
PTHR31935 PTHR31935, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3YV10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADESSADT LRLQFKAMQE LQHRRLQKQM EKKREKELSC QSKADNQEGF
60 70 80 90 100
MVIPDGLSLL DTEEQNLKNI FEKRVLEDEI QHLRSELRET VDENGRLYKL
110 120 130 140 150
LKERDFEIKH LKKKIEEDRF AFTGASGMAG DLVATKIVEL SKKNRGLMAE
160 170 180 190 200
SESAKVRIKQ LTNRIQELEH QLQMASAKPP SKGATDAGAK PLKTQTGDRA
210 220 230 240 250
LLETPEVKAL QDRLAATNLK MSDLRNQIQS AKQELRVAQK VLANEVGEDV
260 270 280 290 300
NIQQLLASPG TWRGRAQQIL VLQSRVRDLE KQLGQRQNKP AGSSSSEVPL
310 320 330 340 350
SSDSRKMTAQ EKNLLRIRSL ERDKQESWEK LASERDTLQT ELEELRKKFE
360 370 380 390 400
GMRSRNKVLS SEVKTLRSQM TTLVEKGRHD DELIDALMDQ LKQLQDILSS
410 420 430 440 450
LSVQEESRRT SQQHLDQKVN SEAQRSSSLV AQLRAMVADR EAKVRQLELE
460 470 480 490 500
IGQLSVQYLH GKGGGEGASP ADARFPEDQT PITNSPASAG DHVGRLGSSR
510 520 530 540 550
SVTSLGHTLV ESALTRPSLP SPHGTSPRFS DSPEQKGWQA QAAEMKALWQ
560 570 580 590 600
AAEVERDRLN EFVTVLQKRV EESSSKLLEA ERRLQEERQR AVLLEQHLEK
610 620 630 640 650
MRLEPSRASV SQKTKNKPGP PAANTKPNSA GSAKKDSSST QLCDMPMESQ
660 670 680 690 700
IQELNARLAI QMEENGILRD ALGSALRGKE EDFRMYHQTL GQVKGVFLQA

LRQQKANKQ
Length:709
Mass (Da):79,750
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6286CA89E824418
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BYN7Q8BYN7_MOUSE
Coiled-coil domain-containing prote...
Ccdc13
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RL14F6RL14_MOUSE
Coiled-coil domain-containing prote...
Ccdc13
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC165080 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57717.1

NCBI Reference Sequences

More...
RefSeqi
NP_082660.1, NM_028384.1
XP_006511967.1, XM_006511904.2
XP_011241227.1, XM_011242925.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.335550

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000135986; ENSMUSP00000114787; ENSMUSG00000079235

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100502861

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100502861

UCSC genome browser

More...
UCSCi
uc012hct.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165080 Genomic DNA No translation available.
CCDSiCCDS57717.1
RefSeqiNP_082660.1, NM_028384.1
XP_006511967.1, XM_006511904.2
XP_011241227.1, XM_011242925.1
UniGeneiMm.335550

3D structure databases

SMRiD3YV10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3YV10, 1 interactor
STRINGi10090.ENSMUSP00000114787

PTM databases

iPTMnetiD3YV10
PhosphoSitePlusiD3YV10

Proteomic databases

MaxQBiD3YV10
PaxDbiD3YV10
PeptideAtlasiD3YV10
PRIDEiD3YV10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000135986; ENSMUSP00000114787; ENSMUSG00000079235
GeneIDi100502861
KEGGimmu:100502861
UCSCiuc012hct.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
152206
MGIiMGI:1920144 Ccdc13

Phylogenomic databases

eggNOGiENOG410IGKT Eukaryota
ENOG410YWT6 LUCA
GeneTreeiENSGT00390000000596
HOGENOMiHOG000111402
InParanoidiD3YV10
OMAiDFRMYHE
OrthoDBi1533296at2759
TreeFamiTF328506

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3YV10

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079235 Expressed in 76 organ(s), highest expression level in testis
ExpressionAtlasiD3YV10 baseline and differential
GenevisibleiD3YV10 MM

Family and domain databases

InterProiView protein in InterPro
IPR038929 CCDC13
PANTHERiPTHR31935 PTHR31935, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD13_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YV10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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