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Entry version 75 (02 Dec 2020)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Alpha-protein kinase 3

Gene

Alpk3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha-protein kinase 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Alpk3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2151224, Alpk3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3YUT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038763, Expressed in gastrocnemius and 114 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3YUT2, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3YUT2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 173Ig-likeInterPro annotationAdd BLAST97
Domaini1251 – 1339Ig-likeInterPro annotationAdd BLAST89
Domaini1367 – 1600Alpha-type protein kinaseInterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni237 – 288DisorderedSequence analysisAdd BLAST52
Regioni302 – 759DisorderedSequence analysisAdd BLAST458
Regioni785 – 950DisorderedSequence analysisAdd BLAST166
Regioni1078 – 1128DisorderedSequence analysisAdd BLAST51
Regioni1147 – 1244DisorderedSequence analysisAdd BLAST98
Regioni1603 – 1680DisorderedSequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi312 – 337PolyampholyteSequence analysisAdd BLAST26
Compositional biasi338 – 352PolarSequence analysisAdd BLAST15
Compositional biasi402 – 426Pro-richSequence analysisAdd BLAST25
Compositional biasi511 – 547PolarSequence analysisAdd BLAST37
Compositional biasi578 – 608PolarSequence analysisAdd BLAST31
Compositional biasi609 – 637PolyampholyteSequence analysisAdd BLAST29
Compositional biasi662 – 693PolarSequence analysisAdd BLAST32
Compositional biasi725 – 748PolarSequence analysisAdd BLAST24
Compositional biasi820 – 838PolyampholyteSequence analysisAdd BLAST19
Compositional biasi870 – 927PolarSequence analysisAdd BLAST58
Compositional biasi1081 – 1112PolyampholyteSequence analysisAdd BLAST32
Compositional biasi1147 – 1169PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1220 – 1244PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1619 – 1680PolarSequence analysisAdd BLAST62

Keywords - Domaini

Immunoglobulin domainARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003270_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGNGGEN

Database of Orthologous Groups

More...
OrthoDBi
32441at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3YUT2

TreeFam database of animal gene trees

More...
TreeFami
TF332629

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02816, Alpha_kinase, 1 hit
PF07679, I-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811, Alpha_kinase, 1 hit
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit
PS50835, IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3YUT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRRAAGRG WGLGGRAGAG GDSEDDGPVW TPGPASRSYL LSVRPEASLS
60 70 80 90 100
SNRLSHPSSG RSTFCSIIAQ LTEETQPLFE TTLKSRAVSE DSDVRFTCIV
110 120 130 140 150
TGYPEPEVTW YKDDIELDRY CGLPKYEITH QGNRHTLQLY RCQEEDAAIY
160 170 180 190 200
QASARNTKGI VSCSGVLEVG TMTEYKIHQR WFAKLKRKAA AKMREIEQSW
210 220 230 240 250
KHGKEASGEA DTLLRKISPD RFQRKRRLSG VEEAVLSTPV REMEEGSSAA
260 270 280 290 300
WQEGETESAQ HPGLGLINSF APGEAPTNGE PAPENGEDEE RGLLTYICEV
310 320 330 340 350
MELGPQNSPP KESGAKKKRK DEESKPGEQK LELEKAEGSQ CSSENVVPST
360 370 380 390 400
DKPNSSRREK STDTQPAQTQ PRGRVARGPG IESTRKTASV LGIQDKVQDV
410 420 430 440 450
PAPAPAPVPA PALAPAPVPV PAPTPVPSRS SEQVYFSLKD MFMETTRAGR
460 470 480 490 500
SQEEEKPPPP STRVAGESPP GKTPVKSRLE KVPMVSSQPT SSMVPPPIKP
510 520 530 540 550
LNRKRFAPPK SKVESTTTSL SSQTSESMAQ SLGKALPSAS TQVPTPPARR
560 570 580 590 600
RHGTRDSPLQ GQTSHKTPGE ALESPATVAP TKSANSSSDT VSVDHDSSGN
610 620 630 640 650
QGATEPMDTE TQEDGRTLVD GRTGSRKKTH TDGKLQVDGR TQGDGAQDRA
660 670 680 690 700
HASPRTQAGE KAPTDVVTQG SERPQSDRSS WKNLVTQRRV DMQVGQMQAG
710 720 730 740 750
ERWQQDPGDA RIQEEEKETQ SAAGSIPVAF ETQSEQLSMA SLSSLPGALK
760 770 780 790 800
GSPSGCPRES QAIECFEKST EAPCVQERSD LMLRSEEAAF RSHEDGLLGP
810 820 830 840 850
PSGNRTYPTQ LPPEGHSEHL GGQTHQRSEQ EDSLSQCPKK EQPQEPLHVG
860 870 880 890 900
LSGGHSTGLS QEVPAMPSLP GTGLTSSLQE ELPGTAASLH TNTDVPLPSR
910 920 930 940 950
DQDFPSSAPT LQLGPGSPTQ SHPPEAMATS SEGACAKEPN VDGRSSGTRS
960 970 980 990 1000
CDPGLIDSLK NYLLLLLKLS SPETSEARAE SQEVADTGGL TSSSTLVPTM
1010 1020 1030 1040 1050
EVAGLSPRTS RRILERVENN HLVQSAQTLL LSPCTSRRLT GLLDREVQAG
1060 1070 1080 1090 1100
QQALAAAQCS RGPCPTPLTI PAIVVGEEGS AGEDSEERTS QESDKKGLLG
1110 1120 1130 1140 1150
EVEGHTVESR TQEPCQEEAM PGEALTGLPA ATPEELALGA RRKRFLPKVR
1160 1170 1180 1190 1200
AGSDGEANKA EERESPTVSP RGPRKGLTPG SPGTPGRERR SPTQARKASM
1210 1220 1230 1240 1250
LEVPGAEEEP ATGDLVSRSK DSGLDSEPAV DEGKQEALAK QRKAKDLLKA
1260 1270 1280 1290 1300
PQVIRKIRVE QFPDSSGSLK LWCQFFNIVS DSVLTWAKDQ HPVGEVNRSA
1310 1320 1330 1340 1350
GDEGPAALAI VQASPTDCGV YRCTIQNEHG SASTDFCLSP EVLSGFISRE
1360 1370 1380 1390 1400
EGEVGEEIEM TPMVFAKGLA DSGCWGDKLF GRLVSEELRG GGHGLQKASR
1410 1420 1430 1440 1450
AKVIYGLEPI FESGRTCIIK VSSLLVFGPS SETSLLGRNY DVTIQGCKIQ
1460 1470 1480 1490 1500
NMSREYCKIF AAEARAASGF GEVPEIIPLY LIYRPANNIP YATLEEDLGK
1510 1520 1530 1540 1550
PLQTYCSRQW GCAGAPAAAS SSEALQKCQT FQHWLYQWTN GSFLVTDLTG
1560 1570 1580 1590 1600
ADWKMTDVQI ATKLRGYQGL KESCFPALLD QFASSHQCNT YCDMLGLKPL
1610 1620 1630 1640 1650
KGPEAAHPQA KAKGSKSPSA GRKGSQLSPQ PQKKGLPSPQ GSRKSAPSSR
1660 1670 1680
ATLQASQAAT VQLLGQPPVQ DGSSKAQSMR
Length:1,680
Mass (Da):180,115
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3339AA79D9763C88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q924C5ALPK3_MOUSE
Alpha-protein kinase 3
Alpk3 Kiaa1330
1,678Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC109220 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_473426.2, NM_054085.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000107348; ENSMUSP00000102971; ENSMUSG00000038763

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116904

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:116904

UCSC genome browser

More...
UCSCi
uc009ibr.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109220 Genomic DNA No translation available.
RefSeqiNP_473426.2, NM_054085.2

3D structure databases

SMRiD3YUT2
ModBaseiSearch...

Proteomic databases

PRIDEiD3YUT2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15507, 53 antibodies

Genome annotation databases

EnsembliENSMUST00000107348; ENSMUSP00000102971; ENSMUSG00000038763
GeneIDi116904
KEGGimmu:116904
UCSCiuc009ibr.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57538
MGIiMGI:2151224, Alpk3

Phylogenomic databases

GeneTreeiENSGT00940000158534
HOGENOMiCLU_003270_1_0_1
OMAiMGNGGEN
OrthoDBi32441at2759
PhylomeDBiD3YUT2
TreeFamiTF332629

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
116904, 1 hit in 17 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038763, Expressed in gastrocnemius and 114 other tissues
GenevisibleiD3YUT2, MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase
PfamiView protein in Pfam
PF02816, Alpha_kinase, 1 hit
PF07679, I-set, 1 hit
SMARTiView protein in SMART
SM00811, Alpha_kinase, 1 hit
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SUPFAMiSSF48726, SSF48726, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit
PS50835, IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3YUT2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3YUT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: December 2, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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