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Protein
Submitted name:

RAS protein activator-like 2

Gene

Rasal2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-5658442 Regulation of RAS by GAPs

Names & Taxonomyi

Protein namesi
Submitted name:
RAS protein activator-like 2Imported
Gene namesi
Name:Rasal2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2443881 Rasal2

PTM / Processingi

Proteomic databases

MaxQBiD3YUS5
PeptideAtlasiD3YUS5
PRIDEiD3YUS5

Expressioni

Gene expression databases

BgeeiENSMUSG00000070565 Expressed in 262 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiD3YUS5 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiD3YUS5, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliD3YUS5
SMRiD3YUS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 287PHInterPro annotationAdd BLAST231
Domaini456 – 648Ras-GAPInterPro annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1088 – 1174Sequence analysisAdd BLAST87

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000231979
OMAiQMQKLLM

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR021887 DUF3498
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12004 DUF3498, 1 hit
PF00616 RasGAP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

D3YUS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTGLESDSP LPPEDLDAVV PVSGAVAGGM LDRILLESVC QQQSWVRVFD
60 70 80 90 100
VKGPPTHRLS CGQSPYTETT SWERKYCILT DSQLVLLNKE KEMPVEGQDQ
110 120 130 140 150
QTDSTKGRCL RRTVSVPSEG QFPEYPQEGT TKLEVPAERS PRRRSISGTS
160 170 180 190 200
TSEKPNSMDT ANTSPFKVPG FFSKRLKGSI KRTKSQSKLD RNTSFRLPSL
210 220 230 240 250
RNADDRSRGL PKLKESRSHE SLLSPCSAVE CLDLGRGEPV SVKPLHSSIL
260 270 280 290 300
GQDFCFEVTY LSGSKCFSCS SASERDKWME NLRRTVQPNK DNCRRAENVL
310 320 330 340 350
RLWIIEAKDL APKKKYFCEL CLDDTLFART TSKTKADNIF WGEHFEFYSL
360 370 380 390 400
PPLHSITVHI YKDVEKKKKK DKNNYVGLVN IPTASVTGRQ FVEKWYPVST
410 420 430 440 450
PTPNKGKTGG PSIRIKSRFQ TITILPMEQY KEFAEFITSN YTMLCSVLEP
460 470 480 490 500
VISVRNKEEL ACALVHILQS TGRAKDFLTD LVMSEVDRCG EHDVLIFREN
510 520 530 540 550
TIATKSIEEY LKLVGQQYLH DALGEFIKAL YESDENCEVD PSKCSSSELM
560 570 580 590 600
DHQSNLKMCC ELAFCKIINS YCVFPRELKE VFASWKQQCL NRGKQDISER
610 620 630 640 650
LISASLFLRF LCPAIMSPSL FNLMQEYPDD RTSRTLTLIA KVIQNLANFA
660 670 680 690 700
KFGNKEEYMA FMNDFLEHEW GGMKRFLLEI SNPDTISNTP GFDGYIDLGR
710 720 730 740 750
ELSVLHSLLW EVVSQLDKAT VAKLGPLPRV LADITKSLTN PTPIQQQLRR
760 770 780 790 800
FAEHSSSPNV SGSLSSGLQR ICEDPTDSDL HKLKSPSQDN TDSYFRGKTL
810 820 830 840 850
LLVQQASSQS MTYSEKDEKE NSLPNGRSIS LMDLQDTHAA QAEHASVMLD
860 870 880 890 900
VPMRLAGSQL SITQVASIKQ LRETQSTPQS APQVRRPLHP ALNQPGSLQP
910 920 930 940 950
LSFQNPVYHL NNPVPAMPKA SADSSLENLS TASSRSQSNS EDFKLSGPSN
960 970 980 990 1000
SSMEDFTKRS SHSEDFSRRH TVPDRHIPLA LPRQNSTGQS QIRKLDHSGL
1010 1020 1030 1040 1050
GARAKAPPSL PHSASLRSTG SMSVASAALM AEPVQNGSRS RQQSSSSRES
1060 1070 1080 1090 1100
PVPKVRAIQR QQTQQVQSPV DSATMSPVER TAAWVLNNGQ YEEDVEETEQ
1110 1120 1130 1140 1150
NQDEAKHAEK YEQEITKLKE RLRVSSRRLE EYERRLLVQE QQMQKLLLEY
1160 1170 1180 1190 1200
KARLEDSEER LRRQQEEKDS QMKSIISRLM AVEEELKKDH AEMQAVIDAK
1210 1220 1230 1240 1250
QKIIDAQEKR IVSLDSANTR LMSALTQVKE RYSMQVRNGI SPTNPTKLSI
1260
TENGEFKNSS C
Length:1,261
Mass (Da):142,011
Last modified:April 20, 2010 - v1
Checksum:i9752F05E0C2202D1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW37E9PW37_MOUSE
RAS protein activator-like 2
Rasal2
1,286Annotation score:
D3Z1T6D3Z1T6_MOUSE
RAS protein activator-like 2
Rasal2
176Annotation score:
D3YWZ9D3YWZ9_MOUSE
RAS protein activator-like 2
Rasal2
323Annotation score:
D3Z7S1D3Z7S1_MOUSE
RAS protein activator-like 2
Rasal2
147Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119220 Genomic DNA No translation available.
AC119897 Genomic DNA No translation available.
AC138382 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000132699; ENSMUSP00000114964; ENSMUSG00000070565

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119220 Genomic DNA No translation available.
AC119897 Genomic DNA No translation available.
AC138382 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD3YUS5
SMRiD3YUS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3YUS5, 1 interactor

Proteomic databases

MaxQBiD3YUS5
PeptideAtlasiD3YUS5
PRIDEiD3YUS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132699; ENSMUSP00000114964; ENSMUSG00000070565

Organism-specific databases

MGIiMGI:2443881 Rasal2

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000231979
OMAiQMQKLLM

Enzyme and pathway databases

ReactomeiR-MMU-5658442 Regulation of RAS by GAPs

Miscellaneous databases

ChiTaRSiRasal2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070565 Expressed in 262 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiD3YUS5 baseline and differential

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR021887 DUF3498
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12004 DUF3498, 1 hit
PF00616 RasGAP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3YUS5_MOUSE
AccessioniPrimary (citable) accession number: D3YUS5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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