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Protein

DNA-binding protein RFX8

Gene

Rfx8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be a transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 94RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein RFX8
Alternative name(s):
Regulatory factor X 8
Gene namesi
Name:Rfx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3588206 Rfx8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003953451 – 596DNA-binding protein RFX8Add BLAST596

Proteomic databases

PaxDbiD3YU81
PRIDEiD3YU81

PTM databases

iPTMnetiD3YU81
PhosphoSitePlusiD3YU81

Expressioni

Gene expression databases

BgeeiENSMUSG00000057173 Expressed in 29 organ(s), highest expression level in testis
GenevisibleiD3YU81 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121212

Structurei

3D structure databases

ProteinModelPortaliD3YU81
SMRiD3YU81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi435 – 438Poly-Leu4
Compositional biasi450 – 455Poly-Glu6

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3712 Eukaryota
ENOG410XSHE LUCA
GeneTreeiENSGT00550000074532
HOGENOMiHOG000155476
InParanoidiD3YU81
OMAiSKAMTLC
OrthoDBiEOG091G07PK
TreeFamiTF342109

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003150 DNA-bd_RFX
IPR039779 RFX-like
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12619 PTHR12619, 1 hit
PfamiView protein in Pfam
PF02257 RFX_DNA_binding, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51526 RFX_DBD, 1 hit

Sequencei

Sequence statusi: Complete.

D3YU81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAVPASPA SGLGLHRGII QWLVDNFCIC EGFSVPRCLM YEIYVETCGQ
60 70 80 90 100
SAQNQVNPAT FGKLVRLVFP DLGTRRLGTR GSARYHYDGI YIKKSSFFYA
110 120 130 140 150
HYCYLLGKKS CHSGNLIAFG KFPDYSNVLQ QEETCENHSP IKKDPMGSPV
160 170 180 190 200
SPFRRCPVWE QELANKYSCK LVVFLADEYC NYCRDILQNV RNQELEKVED
210 220 230 240 250
LITSFWKSRQ QDTVMLMSLP DVRQLLGCYD MQLYKGLEDM LLPDFLEDVS
260 270 280 290 300
IQYLKSVRLF SKRFKLWLLG ALEGFPAILQ ISKLKEVTGF VKRLRRKTYL
310 320 330 340 350
SNMAKTMKMV LKNSRRIGLL KSDLRAIIRE GTLDISKKVL EGDSDHEEEP
360 370 380 390 400
ESHTEMKCLG CLISLLETST DLAELLNCVS SNLQVLVFQP SKNKEDFIKL
410 420 430 440 450
AASFQLKWNF LLTAVSKAMT LSHRDSFGAW HLFHLLLLEY VIHILESCIE
460 470 480 490 500
EEEEEDLGSL QDLLSDDQFL TQPDQALFHP LDSLPTSECA SRNVESPQVT
510 520 530 540 550
LKHTSQSCGP MGMGSVVLQV LGFLVDTATG NKLVQVLLED KTTESAVKLS
560 570 580 590
LPVGQEALIT LSNGQRFVIH ISDVPQSSEN TYCRKSNANV QGGLLE
Length:596
Mass (Da):67,285
Last modified:April 20, 2010 - v1
Checksum:i7ACA3944E1BEF5B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119809 Genomic DNA No translation available.
AC122922 Genomic DNA No translation available.
CCDSiCCDS48245.1
RefSeqiNP_001139132.1, NM_001145660.1
UniGeneiMm.334107

Genome annotation databases

EnsembliENSMUST00000151913; ENSMUSP00000121212; ENSMUSG00000057173
GeneIDi619289
KEGGimmu:619289
UCSCiuc007atn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119809 Genomic DNA No translation available.
AC122922 Genomic DNA No translation available.
CCDSiCCDS48245.1
RefSeqiNP_001139132.1, NM_001145660.1
UniGeneiMm.334107

3D structure databases

ProteinModelPortaliD3YU81
SMRiD3YU81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121212

PTM databases

iPTMnetiD3YU81
PhosphoSitePlusiD3YU81

Proteomic databases

PaxDbiD3YU81
PRIDEiD3YU81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000151913; ENSMUSP00000121212; ENSMUSG00000057173
GeneIDi619289
KEGGimmu:619289
UCSCiuc007atn.2 mouse

Organism-specific databases

CTDi731220
MGIiMGI:3588206 Rfx8

Phylogenomic databases

eggNOGiKOG3712 Eukaryota
ENOG410XSHE LUCA
GeneTreeiENSGT00550000074532
HOGENOMiHOG000155476
InParanoidiD3YU81
OMAiSKAMTLC
OrthoDBiEOG091G07PK
TreeFamiTF342109

Miscellaneous databases

PROiPR:D3YU81
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057173 Expressed in 29 organ(s), highest expression level in testis
GenevisibleiD3YU81 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003150 DNA-bd_RFX
IPR039779 RFX-like
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12619 PTHR12619, 1 hit
PfamiView protein in Pfam
PF02257 RFX_DNA_binding, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51526 RFX_DBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFX8_MOUSE
AccessioniPrimary (citable) accession number: D3YU81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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