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Protein
Submitted name:

Potassium channel, subfamily T, member 2

Gene

Kcnt2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel, subfamily T, member 2Imported
Gene namesi
Name:Kcnt2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3036273 Kcnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 83HelicalSequence analysisAdd BLAST20
Transmembranei103 – 127HelicalSequence analysisAdd BLAST25
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei199 – 217HelicalSequence analysisAdd BLAST19
Transmembranei258 – 281HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiD3YTU6

Expressioni

Gene expression databases

BgeeiENSMUSG00000052726 Expressed in 145 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiD3YTU6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD3YTU6
SMRiD3YTU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 275Ion_trans_2InterPro annotationAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili174 – 194Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3YTU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL
60 70 80 90 100
FFIKNQRSSL RIRLFNFSLK LLSCLLYIIR VLLEKPSQGS EWSHIFWVNR
110 120 130 140 150
SLPLWGLQVS VALISLFETI LLGYLSYKGN IWEQILRIPF ILEIINAVPF
160 170 180 190 200
IISIFWPTLR NLFVPVFLNC WLAKHALENM INDLHRAIQR TQSAMFNQVL
210 220 230 240 250
ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF STVGFGDVTP
260 270 280 290 300
ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK
310 320 330 340 350
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI
360 370 380 390 400
PMWSQRVIYL QGSALKDQDL LRAKMDNAEA CFILSSRCEV DRTSSDHQTI
410 420 430 440 450
LRAWAVKDFA PNCPLYVQIL KPENKFHIKF ADHVVCEEEF KYAMLALNCI
460 470 480 490 500
CPATSTLITL LVHTSRGQEG QQSPEQWQKT YGRCSGNEVY HIVLEESTFF
510 520 530 540 550
AEYEGKSFTY ASFHAHKKFG VCLVGVRRED NKNILLNPGP RYIMNASDIC
560 570 580 590 600
FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID
610 620 630 640 650
LQDTSCRATS GPTLALPSEG GKELRRPSIA PVLEVADTSS IQTCDLLSDQ
660 670 680 690 700
SEDETTPDEE TSSNLEYAKG YPPYSPYIGS SPTFCHLLQE KVPFCCLRLD
710 720 730 740 750
KSCQHNYYED AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN
760 770 780 790 800
PIVLLLDNPL DDLLRCGVTF AANMVVVDKE STMSAEEDYM ADAKTIVNVQ
810 820 830 840 850
TLFRLFSSLS IITELTHPAN MRFMQFRAKD CYSLALSKLE KKERERGSNL
860 870 880 890 900
AFMFRLPFAA GRVFSISMLD TLLYQSFVKD YMISITRLLL GLDTIPGSGF
910 920 930 940 950
LCSMKITEDD LWIRTYARLY QKLCSSTGDV PIGIYRTESQ KLTTSESQIS
960 970 980 990 1000
ISVEEWEDTK DVKDPGHHRS LHRNSTSSDQ SDHPLLRRKS MQWARRLSRK
1010 1020 1030 1040 1050
GPKHSGKTAE KITQQRLNLY RRSERQELAE LVKNRMKHLG LSTVGYDEMN
1060 1070 1080 1090 1100
DHQSTLSYIL INPSPDTRLE LNDVVYLIRP DPLSYLPNSE PSRKNSICNA
1110
AVQDSREETQ L
Length:1,111
Mass (Da):127,503
Last modified:April 20, 2010 - v1
Checksum:i06429EFCCC19716E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z649D3Z649_MOUSE
Potassium channel, subfamily T, mem...
Kcnt2
1,135Annotation score:
D3Z592D3Z592_MOUSE
Potassium channel, subfamily T, mem...
Kcnt2
1,068Annotation score:
A0A0A6YXD8A0A0A6YXD8_MOUSE
Potassium channel, subfamily T, mem...
Kcnt2
71Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120400 Genomic DNA No translation available.
AC156607 Genomic DNA No translation available.
AC156989 Genomic DNA No translation available.
RefSeqiXP_006529629.1, XM_006529566.3
UniGeneiMm.483845

Genome annotation databases

EnsembliENSMUST00000120709; ENSMUSP00000112887; ENSMUSG00000052726
GeneIDi240776

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120400 Genomic DNA No translation available.
AC156607 Genomic DNA No translation available.
AC156989 Genomic DNA No translation available.
RefSeqiXP_006529629.1, XM_006529566.3
UniGeneiMm.483845

3D structure databases

ProteinModelPortaliD3YTU6
SMRiD3YTU6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD3YTU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120709; ENSMUSP00000112887; ENSMUSG00000052726
GeneIDi240776

Organism-specific databases

CTDi343450
MGIiMGI:3036273 Kcnt2

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460

Miscellaneous databases

ChiTaRSiKcnt2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052726 Expressed in 145 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiD3YTU6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3YTU6_MOUSE
AccessioniPrimary (citable) accession number: D3YTU6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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