Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Brucella melitensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY), Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72SubstrateUniRule annotation1
Binding sitei147SubstrateUniRule annotation1
Binding sitei207SubstrateUniRule annotation1
Binding sitei237SubstrateUniRule annotation1
Binding sitei241SubstrateUniRule annotation1
Binding sitei242NADUniRule annotation1
Binding sitei294NADUniRule annotation1
Binding sitei329NADUniRule annotation1
Binding sitei395NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 210NADUniRule annotation3
Nucleotide bindingi271 – 276NADUniRule annotation6
Nucleotide bindingi350 – 352NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
OrganismiBrucella melitensisImported
Taxonomic identifieri29459 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3XE01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 401AdoHcyase_NADInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3XE01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFCLQANCP GLEHAMTASQ DFVVKDISLA DWGRRELDIA ETEMPGLMAA
60 70 80 90 100
REEFGKSQPL KGARISGSLH MTIQTAVLIE TLKVLGAEVR WASCNIFSTQ
110 120 130 140 150
DHAAAAIAAT GTPVFAVKGE TLEEYWTYTD QIFQWPDGEP SNMILDDGGD
160 170 180 190 200
ATMYILIGAR AEAGEDVLSN PQSEEEEVLF AQIKKRMAAT PGFFTKQRAA
210 220 230 240 250
IKGVTEETTT GVNRLYQLQK KGLLPFPAIN VNDSVTKSKF DNKYGCKESL
260 270 280 290 300
VDGIRRGTDV MMAGKVAVVC GYGDVGKGSA QSLAGAGARV KVTEVDPICA
310 320 330 340 350
LQAAMDGFEV VTLDDAASTA DIVVTTTGNK DVITIDHMRK MKDMCIVGNI
360 370 380 390 400
GHFDNEIQVA ALRNLKWTNV KPQVDLIEFP DGKRLILLSE GRLLNLGNAT
410 420 430 440 450
GHPSFVMSAS FTNQVLGQIE LFTRTDAYKN EVYVLPKHLD EKVARLHLDK
460 470 480
LGAKLAVLSE EQAAYIGVTP QGPFKSEHYR Y
Length:481
Mass (Da):52,433
Last modified:April 20, 2010 - v1
Checksum:i94EB532D098E174C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU317366 Genomic DNA Translation: ADC95627.1

Similar proteinsi

Entry informationi

Entry nameiD3XE01_BRUML
AccessioniPrimary (citable) accession number: D3XE01
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health