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Entry version 49 (22 Apr 2020)
Sequence version 1 (20 Apr 2010)
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Protein

Multidrug resistance protein MdtB

Gene

mdtB

Organism
Xenorhabdus bovienii (strain SS-2004)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
XBOV406818:XBJ1_RS11585-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance protein MdtBUniRule annotation
Alternative name(s):
Multidrug transporter MdtBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdtBUniRule annotation
Ordered Locus Names:XBJ1_2731
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenorhabdus bovienii (strain SS-2004)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri406818 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeXenorhabdus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002045 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei342 – 362HelicalUniRule annotationAdd BLAST21
Transmembranei373 – 393HelicalUniRule annotationAdd BLAST21
Transmembranei396 – 416HelicalUniRule annotationAdd BLAST21
Transmembranei440 – 460HelicalUniRule annotationAdd BLAST21
Transmembranei472 – 492HelicalUniRule annotationAdd BLAST21
Transmembranei537 – 557HelicalUniRule annotationAdd BLAST21
Transmembranei869 – 889HelicalUniRule annotationAdd BLAST21
Transmembranei890 – 910HelicalUniRule annotationAdd BLAST21
Transmembranei911 – 931HelicalUniRule annotationAdd BLAST21
Transmembranei968 – 988HelicalUniRule annotationAdd BLAST21
Transmembranei1002 – 1022HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004140311 – 1056Multidrug resistance protein MdtBAdd BLAST1056

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3V7P3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
406818.XBJ1_2731

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3V7P3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002755_1_2_6

KEGG Orthology (KO)

More...
KOi
K07788

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIIPCFY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01423 MdtB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR022831 Multidrug-R_MdtB

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3V7P3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSDSPMTGG GPSRLFILRP VATTLFMIAI LLAGIIGYRM LPVSALPQVD
60 70 80 90 100
YPTIQVVTLY PGASPDIMTS VVTAPLERQF GKISGLKQMT SQSSGGASVI
110 120 130 140 150
TLVFQLSLPL DVAEQDVQAA INAATNLLPN DLPYPPIYSK VNPADPPILT
160 170 180 190 200
LAVTSDALPM IQVQDMVETR IAQRISQVGG VGLVTLAGGQ RPAVRVKFNA
210 220 230 240 250
QAIAAHGLNS ETIRTTIMNA NVSSAKGSFD GPTRSVTLTT NDQMKSIDEY
260 270 280 290 300
RNLIVAYKNG APIRLRDVAT IERGAENTKL GAWANEKPAI VINVQRQPGA
310 320 330 340 350
NVIDTTDNIR AMLPELINSL PKSVNMDILT DRTVTIRASV QDVQFELLLA
360 370 380 390 400
IALVVMVIYV FLRNATATLI PSIAVPLSLV GTFAVMYFCG FSVNNLTLMA
410 420 430 440 450
LTIAAGFVVD DAIVVIENIS RYIERGEKPM AAALKGAGEI GFTIISLTFS
460 470 480 490 500
LIAVLIPLLF MGDIVGRLFR EFAITLAVAI LISAVVSLTL TPMMCARMLK
510 520 530 540 550
AEAEIKHNRF EQASEHFFER IIAIYGGWLK RVLNHPWITL GVAFSTLAFT
560 570 580 590 600
ALLYLTIPKG FFPLQDNGLI QGTLEAPQSI SFNAMSDKQR EVTALLLQDP
610 620 630 640 650
DVENVTTFIG VDGSNSTLNS GRLQITLKPL NQRDIRVDEI IPRLQARVAN
660 670 680 690 700
VPDVKLYLQP TQDLTIDTQV ARTQYQFTLQ GTVSNDLNIW VPKLQEALKQ
710 720 730 740 750
RPELVDVGTD WQNRGLVAYI NVNRDMASRL GISMTAIDNA LYNAFGQRLI
760 770 780 790 800
STIYTQANQY RVILEQDTQN EAGMNAFNNV HLIGTDNKVV PLSTIATVEQ
810 820 830 840 850
QLGYLSINHL QQFPAVTFSF NVAQEASLEA AVNAVKETER SIGMPKNINT
860 870 880 890 900
QFQGATLAFQ DALGNTLWLI LAAVISMYIV LGILYESFIH PVTILSTLPT
910 920 930 940 950
AGVGALLALM VGGYELDIIA IIGIILLIGI VKKNAIMMID FALAAEREKG
960 970 980 990 1000
MSPYDAIFQA CLLRFRPILM TTMAALLGAL PLMLSTGIGA ELRRPLGICM
1010 1020 1030 1040 1050
VGGLIMSQIL TLFTTPVIYL LFDRLANYFK NKRQNRLQSQ NQRELDHSPV

NHQEPL
Length:1,056
Mass (Da):115,246
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD87034ECF51BADBF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN667741 Genomic DNA Translation: CBJ81855.1

NCBI Reference Sequences

More...
RefSeqi
WP_012989141.1, NC_013892.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CBJ81855; CBJ81855; XBJ1_2731

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8832347

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xbo:XBJ1_2731

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|406818.4.peg.2465

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN667741 Genomic DNA Translation: CBJ81855.1
RefSeqiWP_012989141.1, NC_013892.1

3D structure databases

SMRiD3V7P3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi406818.XBJ1_2731

Proteomic databases

PRIDEiD3V7P3

Genome annotation databases

EnsemblBacteriaiCBJ81855; CBJ81855; XBJ1_2731
GeneIDi8832347
KEGGixbo:XBJ1_2731
PATRICifig|406818.4.peg.2465

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiCLU_002755_1_2_6
KOiK07788
OMAiFIIPCFY

Enzyme and pathway databases

BioCyciXBOV406818:XBJ1_RS11585-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
HAMAPiMF_01423 MdtB, 1 hit
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR022831 Multidrug-R_MdtB
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDTB_XENBS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3V7P3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: April 20, 2010
Last modified: April 22, 2020
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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