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Entry version 62 (02 Jun 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

S8 family serine protease

Gene

Nmag_3913

Organism
Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium magadii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
S8 family serine proteaseImported (EC:3.4.21.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Nmag_3913Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pNMAG01Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNatrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium magadii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri547559 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaNatrialbalesNatrialbaceaeNatrialba
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001879 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid pNMAG01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini494 – 561DockerinInterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1528 – 1555DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_249227_0_0_2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1330.10, 1 hit
2.60.40.10, 2 hits
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013784, Carb-bd-like_fold
IPR008969, CarboxyPept-like_regulatory
IPR011635, CARDB
IPR002105, Dockerin_1_rpt
IPR016134, Dockerin_dom
IPR036439, Dockerin_dom_sf
IPR018247, EF_Hand_1_Ca_BS
IPR013783, Ig-like_fold
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR023827, Peptidase_S8_Asp-AS
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR026452, Surf_glycop_sig_pep

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07705, CARDB, 1 hit
PF00404, Dockerin_1, 1 hit
PF00082, Peptidase_S8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723, SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49452, SSF49452, 1 hit
SSF49464, SSF49464, 1 hit
SSF52743, SSF52743, 1 hit
SSF63446, SSF63446, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04207, halo_sig_pep, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51766, DOCKERIN, 1 hit
PS00018, EF_HAND_1, 1 hit
PS00136, SUBTILASE_ASP, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3T1J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSREQLTA LLLTALMVLS LVAIAGTGLA GSVAATEHSD AQSAVDADAD
60 70 80 90 100
GPASIDAELE EASGTEQIYI VLDQYDGQLS DDRDRAIAQL QEHAEVSQAA
110 120 130 140 150
ATEDIDALAG VDVINDYWIT NAIRAEVDTS AVDTAELAMI DGAETIQLRP
160 170 180 190 200
DYEVPEPEPS VEPAVEPDED DYTYGLDQVN ASETWADFNT QGEDVKVAVL
210 220 230 240 250
DTGFDIDHQD LDLYTEDADD PTYPGGWVEI DADGDPVEGS EPYDTHYHGT
260 270 280 290 300
HVGGTVGAAA PADDDTPAYG VAPNVDLQHG LVLPDGSGAD SDTIAGFEYV
310 320 330 340 350
VEEMDSDVVS MSFGAGCGLT GPVYEDAWIP VIQNANDMDV VAVTSSGNSG
360 370 380 390 400
EGCVGSPANT YDSFSIGASN EAGDITDFSS GNTIAADNWD NPDPEWPDEW
410 420 430 440 450
VKPDVSAPGE DVLSAMPDDE YDYLDGTSMS APHVSGVIAL MLSANDDLTQ
460 470 480 490 500
EEIEETLEET AWKPDGEPDE KDVRYGHGIV DAYAAVDEVA AGALEYELGD
510 520 530 540 550
VDQDGDVTVQ DVQLTQQYLQ DMDPEPFAED LADMDRDGEV TTDDLSLLQQ
560 570 580 590 600
KVQGMLDEGE IDITGLDVPD EVDDGEMFEV TVDLENLGEE GAVQEVDLFL
610 620 630 640 650
GDDDEPVDTE VVDMAAPGVD DPIDHPAETT ITFELDAGDL DGGDHTITVE
660 670 680 690 700
TEDADASDTV TVLASNFELS NLDAPDEADR GDEITVSADV ENTGNVDDTQ
710 720 730 740 750
AVEYRFDDLG DALYAQNVTL EADEETTVTF DVGTENITEG TYDHGVFTED
760 770 780 790 800
DEATATIDIL EAFFSVDITD APEELAPGET YNVSADVVNS GDAPDEQTIS
810 820 830 840 850
YEVTEGETDV AVVDGDVDEE ELREELADRG VDDVDLDELV EGADNLADTL
860 870 880 890 900
QDELDDSYDV ETVNADDLLD EVDAYDVFVV NDFDGADVDT FLDELADDQG
910 920 930 940 950
VIYLENWGSS SNAVSDLSDA TDDPSSVEDG FSGSAPIMLD ITDDHALFDG
960 970 980 990 1000
VADAGETIEL HDASDADRAW FDGYSGDVIA DVGDGTPDGA SVGVSEDDDH
1010 1020 1030 1040 1050
VLLAAFGRSS FITNADFSDE SNAIMANAVE HVDDYAGTAS ATDHTSEVVS
1060 1070 1080 1090 1100
LEPNESATVE FTNTLAEDDG ELEWHHVVES DDDIATAPFT IDDGPNWNVK
1110 1120 1130 1140 1150
GTVSDDVTDE PIENASVELE AGNETYTNVT DADGEFGLAN VPAGEHNLTV
1160 1170 1180 1190 1200
DAEGYAAHTE SVEVPEDDIV TVDVGLEELP GTISGDVTAS DDDAPVENAT
1210 1220 1230 1240 1250
IVAENDDGDV HEATTDENGS YELDGVSAGT YVVNVVDTPP GYEIDEIVTV
1260 1270 1280 1290 1300
APGEHVDDVD FVVDRTAGSI EGTVTNAAGV PIADANVIDA DDGAFNVTTA
1310 1320 1330 1340 1350
EDGSYEIEDV TPGTNALRAV ADGYDDSNVE FVDVETGETT TANLTLGTYF
1360 1370 1380 1390 1400
EVDDLAAPDT AEQGEEITVN ATVTNTGEQE DTRTVFYFPP GTDFGTDVID
1410 1420 1430 1440 1450
YQPELAETVT LEGGESTTVE FTYEVGADDE PGEYEHGVSA DEVESTFITI
1460 1470 1480 1490 1500
EGDEDDGEPV FDVSDLDAPA DAEPNETVSV TATLENTGDD AGTQTVTYAF
1510 1520 1530 1540 1550
DDETVANETV SLDATESTEL EFSTELPADE GTYEHTVSSE NDSATAQTDV
1560 1570 1580 1590 1600
EEAGEPEPAY FEVTEHDAPE SVDAGEELTV NATITNTGDE ADQQDIFLFW
1610 1620 1630 1640 1650
DAAMSDLEDA ESVAELREAG IDSMESIELE GGESDTVTLT HEVDSETEPG
1660 1670 1680 1690 1700
TYQYTVSTLQ EMADGEVTVD DAAEVAFPAD PGGFDGAPPG AALGANPFEN
1710
GIANGIGLLG
Length:1,710
Mass (Da):180,930
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8743E39D56566202
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001933 Genomic DNA Translation: ADD07454.1

NCBI Reference Sequences

More...
RefSeqi
WP_012996932.1, NC_013923.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADD07454; ADD07454; Nmag_3913

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8826783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nmg:Nmag_3913

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001933 Genomic DNA Translation: ADD07454.1
RefSeqiWP_012996932.1, NC_013923.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiADD07454; ADD07454; Nmag_3913
GeneIDi8826783
KEGGinmg:Nmag_3913

Phylogenomic databases

HOGENOMiCLU_249227_0_0_2

Family and domain databases

Gene3Di1.10.1330.10, 1 hit
2.60.40.10, 2 hits
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR013784, Carb-bd-like_fold
IPR008969, CarboxyPept-like_regulatory
IPR011635, CARDB
IPR002105, Dockerin_1_rpt
IPR016134, Dockerin_dom
IPR036439, Dockerin_dom_sf
IPR018247, EF_Hand_1_Ca_BS
IPR013783, Ig-like_fold
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR023827, Peptidase_S8_Asp-AS
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR026452, Surf_glycop_sig_pep
PfamiView protein in Pfam
PF07705, CARDB, 1 hit
PF00404, Dockerin_1, 1 hit
PF00082, Peptidase_S8, 1 hit
PRINTSiPR00723, SUBTILISIN
SUPFAMiSSF49452, SSF49452, 1 hit
SSF49464, SSF49464, 1 hit
SSF52743, SSF52743, 1 hit
SSF63446, SSF63446, 1 hit
TIGRFAMsiTIGR04207, halo_sig_pep, 1 hit
PROSITEiView protein in PROSITE
PS51766, DOCKERIN, 1 hit
PS00018, EF_HAND_1, 1 hit
PS00136, SUBTILASE_ASP, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3T1J5_NATMM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3T1J5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 2, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

PlasmidImported, Reference proteomeImported
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