UniProtKB - D3PCL0 (D3PCL0_DEFDS)
Protein
D-3-phosphoglycerate dehydrogenase
Gene
serA
Organism
Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)
Status
Functioni
Catalytic activityi
- EC:1.1.1.95UniRule annotation
: L-serine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- D-3-phosphoglycerate dehydrogenase (serA)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- NAD binding Source: UniProtKB-UniRule
- phosphoglycerate dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- L-serine biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | OxidoreductaseUniRule annotationImported |
Biological process | Amino-acid biosynthesis, Serine biosynthesisUniRule annotation |
Ligand | NADUniRule annotation |
Enzyme and pathway databases
BioCyci | DDES639282:G1G36-869-MONOMER |
UniPathwayi | UPA00135;UER00196 |
Names & Taxonomyi
Protein namesi | Recommended name: D-3-phosphoglycerate dehydrogenaseUniRule annotation (EC:1.1.1.95UniRule annotation) |
Gene namesi | Name:serAImported Ordered Locus Names:DEFDS_0857Imported |
Organismi | Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1)Imported |
Taxonomic identifieri | 639282 [NCBI] |
Taxonomic lineagei | Bacteria › Deferribacteres › Deferribacterales › Deferribacteraceae › Deferribacter › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 469 – 540 | ACTInterPro annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
HOGENOMi | HOG000136693 |
KOi | K00058 |
OMAi | NIAGMQV |
OrthoDBi | 1638924at2 |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR002912 ACT_dom IPR029009 ASB_dom_sf IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf IPR006236 PGDH |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit PF01842 ACT, 1 hit |
SUPFAMi | SSF143548 SSF143548, 1 hit SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR01327 PGDH, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
D3PCL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKFKVLITD HIAEEGIKIL LDSKDIEVEE KPGISHEELK EIIGNYDAII
60 70 80 90 100
TRSGTTITAD LLENPGKLKI IGRAGVGLDN VDIEAASKKG IIVMNAPTGN
110 120 130 140 150
TLAATELTMG MMLAAARKIP AAHISLKNGE WNRKKFMGIQ LFNKTLGIVG
160 170 180 190 200
LGRIGSNVAI RAKSFGMKIV AYDPYIKKSK AESLGVTLLD NLEDLLKISD
210 220 230 240 250
VITFHTPLTK ETKNMITKKE IELMKDGVIL VNCARGGIIN ENDLYDALKS
260 270 280 290 300
GKVFTAAIDV FEKEPPKGNK LLELDNLFVT PHIGANTEEG QKGVAVIIAE
310 320 330 340 350
QIVNALHGKS YINAVNIPFM KSQLPEDLQI YFELIEKISK LAAQTVKGRP
360 370 380 390 400
DEIKVTLVGK RFEDDICERT FDTPFSYQPF TIAAIKGFLE VRLQESVSYI
410 420 430 440 450
NAPYFAKDRK INVIESKQET YDKYNDLLIL EIKTDKEHRI IAGTVFNNKE
460 470 480 490 500
GRIVLFDDFR IDIIPEGTFL YFRNIDRPGV IGKVGTILGE NNINIAGFEL
510 520 530 540
ARQKGGEAIA FVSVDNEIPE SVLSEIKKID GMLEVNLVEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP011529 Genomic DNA Translation: BAI80333.1 |
RefSeqi | WP_013007581.1, NC_013939.1 |
Genome annotation databases
EnsemblBacteriai | BAI80333; BAI80333; DEFDS_0857 |
KEGGi | ddf:DEFDS_0857 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP011529 Genomic DNA Translation: BAI80333.1 |
RefSeqi | WP_013007581.1, NC_013939.1 |
3D structure databases
ProteinModelPortali | D3PCL0 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 639282.DEFDS_0857 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | BAI80333; BAI80333; DEFDS_0857 |
KEGGi | ddf:DEFDS_0857 |
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
HOGENOMi | HOG000136693 |
KOi | K00058 |
OMAi | NIAGMQV |
OrthoDBi | 1638924at2 |
Enzyme and pathway databases
UniPathwayi | UPA00135;UER00196 |
BioCyci | DDES639282:G1G36-869-MONOMER |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR002912 ACT_dom IPR029009 ASB_dom_sf IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf IPR006236 PGDH |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit PF01842 ACT, 1 hit |
SUPFAMi | SSF143548 SSF143548, 1 hit SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR01327 PGDH, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | D3PCL0_DEFDS | |
Accessioni | D3PCL0Primary (citable) accession number: D3PCL0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 16, 2019 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |