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Entry version 48 (26 Feb 2020)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

BLM helicase

Gene

BLM

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BLM helicaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BLMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini644 – 819Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini845 – 992Helicase C-terminalInterPro annotationAdd BLAST148
Domaini1180 – 1260HRDCInterPro annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 117DisorderedSequence analysisAdd BLAST100
Regioni133 – 175DisorderedSequence analysisAdd BLAST43
Regioni198 – 227DisorderedSequence analysisAdd BLAST30
Regioni269 – 306DisorderedSequence analysisAdd BLAST38
Regioni361 – 412DisorderedSequence analysisAdd BLAST52
Regioni457 – 520DisorderedSequence analysisAdd BLAST64
Regioni578 – 605DisorderedSequence analysisAdd BLAST28
Regioni1265 – 1380DisorderedSequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 107PolarSequence analysisAdd BLAST15
Compositional biasi206 – 224PolarSequence analysisAdd BLAST19
Compositional biasi361 – 386PolarSequence analysisAdd BLAST26
Compositional biasi396 – 412PolarSequence analysisAdd BLAST17
Compositional biasi459 – 483PolarSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0351 Eukaryota
COG0514 LUCA

Database of Orthologous Groups

More...
OrthoDBi
445763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3KR64

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012532 BDHCT
IPR032437 BLM_N
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08072 BDHCT, 1 hit
PF16202 BLM_N, 2 hits
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00614 recQ_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3KR64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVPQNNLR EQLRLHSARG ALSKVLPARS RPAAFTFRRT HSPAAGPAAL
60 70 80 90 100
RDKDVNTSLG SGGVARPKDL RVGPPGARPA LPGPAGSSGP TAGAPPGSVS
110 120 130 140 150
VSLPSSGPAA YTGDEWDDMD DFDLSGFEKK FSRPAVLSPK GPRTPQGRGL
160 170 180 190 200
RVSKARADVG PQEHGSEVSC SQGSSQGSLI CLGDAGAPAA AVLSDNGMEE
210 220 230 240 250
ARAATNGGSG ESQKLSNGEK SSQLEPGDVG NELLADIELE EDDYLDVVPP
260 270 280 290 300
SPEEELPSFS PSVRNVSNIF KESPTDGRSA VHGTESEPEL MAPKQPAAEQ
310 320 330 340 350
DSSAEHADKG LHLEQQLYSV MEDICKLVDA IPLHELTSIS CAKELLQQRE
360 370 380 390 400
LRRKLLADSG ALNTNSVNGP RNWKACVQQD PSSRPGTPLC SGPGRGVSSV
410 420 430 440 450
GSTPKSTNLP SVLSRTVNSS SFSTIRNQTL DKLDTSYSSK ETDQEVICLE
460 470 480 490 500
PAALPSPKVN GKGSTSLSRP SEASFNGSWC EKPTGRDSGN WRVPERPTAS
510 520 530 540 550
TALKAQHTAP AGNPASGCWD VNDTDFDLDH FDIDDFDEGW EEAVAPEAAP
560 570 580 590 600
EAPPAPQWQP LREGSASLRC RLLAAAAGSA PGPHPTAPKS GCGISAKSSS
610 620 630 640 650
EPLVHNPAHE RFRGMKFSHS EEMLKIFHRK FGLHSFRTNQ LEAINAALLG
660 670 680 690 700
EDCFILMPTG GGKSLCYQLP ACVSAGVTVV ISPLRSLIID QVQKLKTLDI
710 720 730 740 750
AATYLTGDIT DADASKTYMQ LSKKDPIIKL LYVTPEKVCA SNRLLSALEN
760 770 780 790 800
LYDRKLLARF VIDEAHCVSQ WGHDFRKDYK RLNMLRKKFH SVPMMALTAT
810 820 830 840 850
ANPRVQKDIQ NQLEMLKPQV FTMSFNRHNL KYDVLPKKPK KVAMDCLEWI
860 870 880 890 900
KKYHPHDSGI IYCLSRHECD TTAAILQKEG LAALAYHAGL TDSNRDLVQK
910 920 930 940 950
KWVNQEGCQV ICATIAFGMG IDKPDVRYVI HASLPKSIEG YYQESGRAGR
960 970 980 990 1000
DGEMSHCLLF YSYSDVTRLR RLILMEKDGN SHTRQTHFNN LYSMVHYCEN
1010 1020 1030 1040 1050
VVDCRRIQLL AYFGETDFNP NFCKDHPEVI CDNCSRKKDY KSRNVTDEVK
1060 1070 1080 1090 1100
SIIRFVQQHC GQVGGINGNR NTGSGRYTLN MMVDIFLGAK SAKIQSGIFG
1110 1120 1130 1140 1150
KGAAYSRHNV ERLFRKLVLD KILDEDLYIT ANDQAVAYVV LGEKAQAVLN
1160 1170 1180 1190 1200
GLLQVEFHET ENASAIRKQR ASVTKMSQRE EMVKKCLGEL TDTCKTLGKI
1210 1220 1230 1240 1250
FDVHYFNIFS TSTLKKIAET LSSDAEVLLQ IDGVTEDKLE KYGAEIIKVM
1260 1270 1280 1290 1300
DKYSEWTTPE DAACQSVDTA PGSAGTPGSE EEAADDVVTS SYFGGNANQR
1310 1320 1330 1340 1350
RKRKRLPNSG ESKRKKTSSG GSQQFYSKGA RYRRARRAPG SRAAAPAQSS
1360 1370 1380
ALRGAGARLG IMAPPKPSSR HFLQPSYAVL
Length:1,380
Mass (Da):150,184
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7D1642847AEF5B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032092 mRNA Translation: BAI79322.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032092 mRNA Translation: BAI79322.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
COG0514 LUCA
OrthoDBi445763at2759
PhylomeDBiD3KR64

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR012532 BDHCT
IPR032437 BLM_N
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF08072 BDHCT, 1 hit
PF16202 BLM_N, 2 hits
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3KR64_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3KR64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 26, 2020
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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