Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 46 (02 Jun 2021)
Sequence version 1 (23 Mar 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Carnosine synthase 1

Gene

CARNS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+Sequence analysisNote: Binds 2 manganese ions per subunit.Sequence analysis

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.033 mM for beta-alanine1 Publication
  2. KM=0.35 mM for gamma-aminobutyrate1 Publication
  3. KM=0.10 mM for L-histidine1 Publication
  4. KM=1.42 mM for L-lysine1 Publication
  5. KM=1.62 mM for L-ornithine1 Publication
  6. KM=0.39 mM for N-methylhistidine1 Publication
  1. Vmax=119 nmol/min/mg enzyme toward beta-alanine1 Publication
  2. Vmax=84.1 nmol/min/mg enzyme toward gamma-aminobutyrate1 Publication
  3. Vmax=3.30 nmol/min/mg enzyme toward L-histidine1 Publication
  4. Vmax=3.43 nmol/min/mg enzyme toward L-lysine1 Publication
  5. Vmax=2.54 nmol/min/mg enzyme toward L-ornithine1 Publication
  6. Vmax=3.51 nmol/min/mg enzyme toward N-methylhistidine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi782Manganese 1Sequence analysis1
Metal bindingi794Manganese 1Sequence analysis1
Metal bindingi794Manganese 2Sequence analysis1
Metal bindingi796Manganese 2Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi650 – 716ATPPROSITE-ProRule annotationAdd BLAST67

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.2.11, 1306

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carnosine synthase 1Imported (EC:6.3.2.11)
Alternative name(s):
ATP-grasp domain-containing protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARNS1By similarity
Synonyms:ATPGD1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003953111 – 930Carnosine synthase 1Add BLAST930

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Curated1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini624 – 825ATP-graspPROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3KCC4

Database of Orthologous Groups

More...
OrthoDBi
106215at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3KCC4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011761, ATP-grasp
IPR041472, BL00235/CARNS1_N
IPR031046, CARNS1

The PANTHER Classification System

More...
PANTHERi
PTHR48066, PTHR48066, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18130, ATPgrasp_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975, ATP_GRASP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3KCC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISVDRLSEE QALGMKEQEW AGPEALCPGW QEEEVSDGEG PEDSGHPDPT
60 70 80 90 100
AHAYEVLQHT LRLEGMPLTI DRTGQPRTGS GPLDMTVCVL GSPTAFLPVL
110 120 130 140 150
LEGGTRYPGA MVLCLAPAWA SRVPSETSPG SWSLLLSRGV SFEAGGCTAL
160 170 180 190 200
EEFVPPRRAT YVTGTFGSEG SWEGELARDL DCPTGGSALL TRWLEDPLLS
210 220 230 240 250
RWLLSARAGL PVPPTLAFIT GLWETLPEEP EPPGVHLVRL QDPQGQESLV
260 270 280 290 300
RDEVGAFLEG SSMQPYDQVA VRLSGWRWRG TDPHSTHRKV EGEAVAQAVA
310 320 330 340 350
ALLKGLREEE SILLEALVPT ARLPTLPPRS AAPRLPMALR ICTVVCRSWG
360 370 380 390 400
DRPQLCQVAC TAGRAEVPVR HGSALPLGLD SSLRQWGLAD AAQRQALAGQ
410 420 430 440 450
LREAAEAAMA ALLAAEGELS PAQRGGARAH TDVLGVDFLL ACVDGTLELV
460 470 480 490 500
ALSANCLRCL ETCLLAEGMG HDVGQPAGDV PRLLAECLLH RAQCHLVEGK
510 520 530 540 550
DILLIGAGGV SKSFVWEAAR EYGLRIHLVE SDPEHFAAGL VETFLPYDSR
560 570 580 590 600
EHRRDEEHAE RVLEMLRARG LRPDACLSYW DDCVVLTALL CQRLGLPGCP
610 620 630 640 650
PAAVRLAKQK SRTHQHLQRC RRGRPPPAAF SVPCRRLRSH GDVERAAGAV
660 670 680 690 700
PFPAVAKLEF GAGAVGVRLV ENAGQCHAHA AQLWHDLRAD ADHPGIGLGW
710 720 730 740 750
GNAMLLMEYV PGTEHDVDLV LFEGRLLGAW VSDNGPTRVP TFLETAATLP
760 770 780 790 800
SCLPADRQAQ LVRAALRCCR ACGLRHGVFN VELKLSPAGP RLLEINPRMG
810 820 830 840 850
GFYLRDWMRA VYGPDLLLAA VLLALGLPPV LPSRPAPRQQ LAGVMCLASE
860 870 880 890 900
HGRALRGGVM AALQGLQRRG LVRLNPLFEE AGGRYEEPCL SVACAGDGPA
910 920 930
EACGRLLGLC QALGIDSPQY PVGHFLSHFK
Length:930
Mass (Da):100,060
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A152BDCD8E003F8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GU453679 mRNA Translation: ADB91406.1

NCBI Reference Sequences

More...
RefSeqi
NP_001166064.1, NM_001172593.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100359387

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:100359387

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU453679 mRNA Translation: ADB91406.1
RefSeqiNP_001166064.1, NM_001172593.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100359387
KEGGigga:100359387

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57571

Phylogenomic databases

InParanoidiD3KCC4
OrthoDBi106215at2759
PhylomeDBiD3KCC4

Enzyme and pathway databases

BRENDAi6.3.2.11, 1306

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3KCC4

Family and domain databases

InterProiView protein in InterPro
IPR011761, ATP-grasp
IPR041472, BL00235/CARNS1_N
IPR031046, CARNS1
PANTHERiPTHR48066, PTHR48066, 1 hit
PfamiView protein in Pfam
PF18130, ATPgrasp_N, 1 hit
PROSITEiView protein in PROSITE
PS50975, ATP_GRASP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRNS1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3KCC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 23, 2010
Last modified: June 2, 2021
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again