UniProtKB - D3JZW5 (D3JZW5_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase parkin
Gene
PRKN
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ligase activity Source: UniProtKB-KW
Keywordsi
Molecular function | LigaseImported |
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase parkinImportedSubmitted name: Truncated parkin variant SV4,8DELImportedSubmitted name: Truncated parkin variant SV4DELImported (EC:6.3.2.19Imported) |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8607, PRKN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 72 | Ubiquitin-likeInterPro annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 112 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 124 – 143 | DisorderedSequence analysisAdd BLAST | 20 |
Family and domain databases
InterProi | View protein in InterPro IPR015496, Ubiquilin IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019956, Ubiquitin_dom |
PANTHERi | PTHR10677, PTHR10677, 1 hit |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
D3JZW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL
60 70 80 90 100
RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ
110 120 130 140
SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPGSI LLG
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO60260 | PRKN_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN PARK2 | 465 | Annotation score: | ||
A0A087X0Z9 | A0A087X0Z9_HUMAN | RBR-type E3 ubiquitin transferase | PRKN | 176 | Annotation score: | ||
A0A087WX46 | A0A087WX46_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN | 74 | Annotation score: | ||
B1AKC3 | B1AKC3_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN PARK2 | 368 | Annotation score: | ||
A0A669KBE3 | A0A669KBE3_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN | 362 | Annotation score: | ||
D3K2X1 | D3K2X1_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN PARK2 | 95 | Annotation score: | ||
A0A087WU39 | A0A087WU39_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN | 201 | Annotation score: | ||
A0A087X1E2 | A0A087X1E2_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN | 87 | Annotation score: | ||
A0A6I8PII0 | A0A6I8PII0_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN | 115 | Annotation score: | ||
A0A6I8PRS9 | A0A6I8PRS9_HUMAN | E3 ubiquitin-protein ligase parkin | PRKN | 63 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035697 Genomic DNA No translation available. AL078583 Genomic DNA No translation available. AL132982 Genomic DNA No translation available. AL138716 Genomic DNA No translation available. AL445215 Genomic DNA No translation available. KF458345 Genomic DNA No translation available. KF458347 Genomic DNA No translation available. KF495747 Genomic DNA No translation available. GU345838 mRNA Translation: ADB90269.1 GU361466 mRNA Translation: ADB91978.1 |
Genome annotation databases
Ensembli | ENST00000338468; ENSP00000343589; ENSG00000185345 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035697 Genomic DNA No translation available. AL078583 Genomic DNA No translation available. AL132982 Genomic DNA No translation available. AL138716 Genomic DNA No translation available. AL445215 Genomic DNA No translation available. KF458345 Genomic DNA No translation available. KF458347 Genomic DNA No translation available. KF495747 Genomic DNA No translation available. GU345838 mRNA Translation: ADB90269.1 GU361466 mRNA Translation: ADB91978.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENST00000338468; ENSP00000343589; ENSG00000185345 |
Organism-specific databases
HGNCi | HGNC:8607, PRKN |
GenAtlasi | Search... |
Miscellaneous databases
ChiTaRSi | PARK2, human |
Family and domain databases
InterProi | View protein in InterPro IPR015496, Ubiquilin IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019956, Ubiquitin_dom |
PANTHERi | PTHR10677, PTHR10677, 1 hit |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3JZW5_HUMAN | |
Accessioni | D3JZW5Primary (citable) accession number: D3JZW5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 23, 2010 |
Last sequence update: | March 23, 2010 | |
Last modified: | December 2, 2020 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |