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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Legionella longbeachae serogroup 1 (strain NSW150)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

BioCyciLLON661367:LLO_RS13990-MONOMER
UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
Ordered Locus Names:LLO_2759Imported
OrganismiLegionella longbeachae serogroup 1 (strain NSW150)Imported
Taxonomic identifieri661367 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000001060 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 48HelicalUniRule annotationAdd BLAST22
Transmembranei69 – 91HelicalUniRule annotationAdd BLAST23
Transmembranei97 – 114HelicalUniRule annotationAdd BLAST18
Transmembranei134 – 152HelicalUniRule annotationAdd BLAST19
Transmembranei164 – 185HelicalUniRule annotationAdd BLAST22
Transmembranei197 – 219HelicalUniRule annotationAdd BLAST23
Transmembranei239 – 256HelicalUniRule annotationAdd BLAST18
Transmembranei263 – 284HelicalUniRule annotationAdd BLAST22
Transmembranei290 – 311HelicalUniRule annotationAdd BLAST22
Transmembranei339 – 358HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi661367.LLO_2759

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3HL71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYWLTQLFQ GQYHALRVFQ YLTFRSILAS LTALIVGLVC GPIMIRWLRG
60 70 80 90 100
LQIGQMVRDD GPQSHLSKAG TPTMGGVLIV LAVTVSCLLW GDLQQPSLWL
110 120 130 140 150
VLLVTLGNGV VGWVDDYRKL VLKNSKGLPA RWKYFWQSVV ALIAVIYLYM
160 170 180 190 200
HADLPVHTQL TVPFFKSLTI GLGIFFPVLG YFVIVGSSNA VNLTDGLDGL
210 220 230 240 250
AIMPIVMVAG ALGIFAYASS NAVYAPYLGI PYVPNTGELT IFCSSIVGAG
260 270 280 290 300
LGFLWYNSYP AQVFMGDVGS LALGAALGIV AVVIREELVL LMMGGLFVIE
310 320 330 340 350
TISVILQVGY FKYTHGKRLF RMAPLHHHFE LKGWSEPKII VRFWIITVVF
360
VLCGLATLKL R
Length:361
Mass (Da):39,747
Last modified:March 23, 2010 - v1
Checksum:iC9CC24B735FE75D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN650140 Genomic DNA Translation: CBJ13190.1
RefSeqiWP_003635187.1, NC_013861.1

Genome annotation databases

EnsemblBacteriaiCBJ13190; CBJ13190; LLO_2759
KEGGillo:LLO_2759

Similar proteinsi

Entry informationi

Entry nameiD3HL71_LEGLN
AccessioniPrimary (citable) accession number: D3HL71
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 20, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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