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UniProtKB - D3H1Z2 (D3H1Z2_ECO44)
Protein
Endo-type membrane-bound lytic murein transglycosylase A
Gene
mltE
Organism
Escherichia coli O44:H18 (strain 042 / EAEC)
Status
Functioni
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
UniRule annotationCatalytic activityi
- Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation EC:4.2.2.n2
- Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.ARBA annotation EC:4.2.2.n1
GO - Molecular functioni
- carbon-oxygen lyase activity, acting on polysaccharides Source: UniProtKB-UniRule
- hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
- lytic endotransglycosylase activity Source: InterPro
GO - Biological processi
- cell wall macromolecule catabolic process Source: UniProtKB-UniRule
- cell wall organization Source: UniProtKB-KW
- peptidoglycan metabolic process Source: InterPro
Keywordsi
Molecular function | GlycosidaseImported, Hydrolase, LyaseUniRule annotationARBA annotation |
Biological process | Cell wall biogenesis/degradationUniRule annotationARBA annotation |
Protein family/group databases
CAZyi | GH23, Glycoside Hydrolase Family 23 |
Names & Taxonomyi
Protein namesi | Recommended name: Endo-type membrane-bound lytic murein transglycosylase AUniRule annotation (EC:4.2.2.n2UniRule annotation)Alternative name(s): Peptidoglycan lytic endotransglycosylaseUniRule annotation |
Gene namesi | Name:mltEImported Synonyms:emtAUniRule annotation Ordered Locus Names:EC042_1244Imported |
Organismi | Escherichia coli O44:H18 (strain 042 / EAEC)Imported |
Taxonomic identifieri | 216592 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation
Other locations
- cell outer membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell outer membraneUniRule annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5008952359 | 22 – 203 | Endo-type membrane-bound lytic murein transglycosylase ASequence analysisAdd BLAST | 182 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 168 | SLTInterPro annotationAdd BLAST | 126 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_103257_0_0_6 |
OMAi | RYLWKVK |
Family and domain databases
HAMAPi | MF_01381, EmtA, 1 hit |
InterProi | View protein in InterPro IPR023946, EmtA IPR023346, Lysozyme-like_dom_sf IPR000189, Transglyc_AS IPR008258, Transglycosylase_SLT_dom_1 |
Pfami | View protein in Pfam PF01464, SLT, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00922, TRANSGLYCOSYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
D3H1Z2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLRWFAFLI VLLAGCSSKH DYTNPPWNAK VPVQRAMQWM PISQKAGAAW
60 70 80 90 100
GVDPQLITAI IAIESGGNPN AVSKSNAIGL MQLKASTSGR DVYRRMGWSG
110 120 130 140 150
EPTTSELKNP ERNISMGAAY LNILETGPLA GIEDPKVLQY ALVVSYANGA
160 170 180 190 200
GALLRTFSSD RKKAISKIND LDADEFLDHV ARNHPAPQAP RYIYKLEQAL
DAM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FN554766 Genomic DNA Translation: CBG34064.1 |
RefSeqi | WP_001295616.1, NZ_CP042934.2 |
Genome annotation databases
GeneIDi | 67417489 |
KEGGi | elo:EC042_1244 |
PATRICi | fig|216592.3.peg.1290 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FN554766 Genomic DNA Translation: CBG34064.1 |
RefSeqi | WP_001295616.1, NZ_CP042934.2 |
3D structure databases
SMRi | D3H1Z2 |
ModBasei | Search... |
Protein family/group databases
CAZyi | GH23, Glycoside Hydrolase Family 23 |
Genome annotation databases
GeneIDi | 67417489 |
KEGGi | elo:EC042_1244 |
PATRICi | fig|216592.3.peg.1290 |
Phylogenomic databases
HOGENOMi | CLU_103257_0_0_6 |
OMAi | RYLWKVK |
Family and domain databases
HAMAPi | MF_01381, EmtA, 1 hit |
InterProi | View protein in InterPro IPR023946, EmtA IPR023346, Lysozyme-like_dom_sf IPR000189, Transglyc_AS IPR008258, Transglycosylase_SLT_dom_1 |
Pfami | View protein in Pfam PF01464, SLT, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00922, TRANSGLYCOSYLASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3H1Z2_ECO44 | |
Accessioni | D3H1Z2Primary (citable) accession number: D3H1Z2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 23, 2010 |
Last sequence update: | March 23, 2010 | |
Last modified: | January 19, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |