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Entry version 53 (22 Apr 2020)
Sequence version 1 (23 Mar 2010)
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Protein
Submitted name:

Putative type VI secretion protein

Gene

EC042_4533

Organism
Escherichia coli O44:H18 (strain 042 / EAEC)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ECOL216592:EC042_RS24215-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative type VI secretion proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:EC042_4533Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O44:H18 (strain 042 / EAEC)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri216592 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001407 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-61956N

Protein interaction database and analysis system

More...
IntActi
D3GUW4, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini495 – 598T6SS_VgrInterPro annotationAdd BLAST104
Domaini616 – 764DUF2345InterPro annotationAdd BLAST149

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili581 – 601Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_004121_4_0_6

KEGG Orthology (KO)

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KOi
K11904

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPQIHSP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018769 DUF2345_Vgr_C
IPR028244 T6SS_Rhs_Vgr_dom
IPR017847 T6SS_RhsGE_Vgr_subset
IPR006533 T6SS_Vgr_RhsGE
IPR037026 Vgr_OB-fold_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10106 DUF2345, 1 hit
PF13296 T6SS_Vgr, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01646 vgr_GE, 1 hit
TIGR03361 VI_Rhs_Vgr, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3GUW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLTDSLQNV LSGVGTLNRY RLDIPSCPSS LDVEDFSGTE GISKIYRYDI
60 70 80 90 100
IFTSTDRYPD AAWFLRKSAT LIMGTGLLES LTEQKKVHGV ITDFRRISGS
110 120 130 140 150
EDQAQYRITL KPFISLLDKQ FRTHRFFVNK SVPEVVEQIL TEHGLKGWEY
160 170 180 190 200
EFSLKRTYPK REQINQYQES DLRFIQRLLA EVGIFYFFTL HPDAQTEVIH
210 220 230 240 250
FGDVQAALIF DKTLPVNSPS GMSDSGTDSV WALNVEHRVV ESRVITNDYN
260 270 280 290 300
HREAQNILMS VPADMTRGEG YDTSYGEVYH YRPRHTERGD KIDPAPETAN
310 320 330 340 350
FWARLDHERF LAEQTRITGK STDASLLPAQ VLTITDSTPP VLPAPLQEPV
360 370 380 390 400
LLTQLLFTGS RKSALQVMLS AVPYSEIVCW RPPLLTRPKI TGTMTARVTS
410 420 430 440 450
AKEGDIYAWQ DASGMYRVKF DADRDDKNPG QESMPVRLAK PYSGDAYGFH
460 470 480 490 500
FPLIQGTEVA IAFEEGDPDR PYIAHALHDS RHVDHVTDKN GTRNVIRTPA
510 520 530 540 550
NNKLRMEDKR GEEHIKLSTE YGGKTQLNLG HNVDASRELR GEGAELRTDD
560 570 580 590 600
WISIRGGKGI FISADMQPQA QGKMLDMDEA IRQLEQALSL ARSMAKAATA
610 620 630 640 650
ANATQGDISC QQRLNASLTD LTAPGMLLHA PDGIGMVSAR ALRIASGSES
660 670 680 690 700
VGIMSGDNTD ITAGQSFTVV AEGAVSLLSR NQGMQLLAAK GRVNIQAQSD
710 720 730 740 750
DLSMSSQQNL DIQSSEGKVT VSANQELILA CGGAYIKLSG GNIELGCPGQ
760 770 780 790 800
ILLKSTNMQK MGPTSLDIAS VEMPRGFGGG FILTDEAGVP QPSTPYRLTT
810 820 830 840
AEGDILQGIT DENGKTAPVN TSIPSVVKVE FGKVKIHGET E
Length:841
Mass (Da):92,552
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE11BB9527AAD5C3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN554766 Genomic DNA Translation: CBG37355.1

NCBI Reference Sequences

More...
RefSeqi
WP_001054503.1, NC_017626.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
elo:EC042_4533

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|216592.3.peg.4710

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554766 Genomic DNA Translation: CBG37355.1
RefSeqiWP_001054503.1, NC_017626.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-61956N
IntActiD3GUW4, 2 interactors

Genome annotation databases

KEGGielo:EC042_4533
PATRICifig|216592.3.peg.4710

Phylogenomic databases

HOGENOMiCLU_004121_4_0_6
KOiK11904
OMAiNPQIHSP

Enzyme and pathway databases

BioCyciECOL216592:EC042_RS24215-MONOMER

Family and domain databases

Gene3Di2.40.50.230, 1 hit
InterProiView protein in InterPro
IPR018769 DUF2345_Vgr_C
IPR028244 T6SS_Rhs_Vgr_dom
IPR017847 T6SS_RhsGE_Vgr_subset
IPR006533 T6SS_Vgr_RhsGE
IPR037026 Vgr_OB-fold_dom_sf
PfamiView protein in Pfam
PF10106 DUF2345, 1 hit
PF13296 T6SS_Vgr, 1 hit
TIGRFAMsiTIGR01646 vgr_GE, 1 hit
TIGR03361 VI_Rhs_Vgr, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3GUW4_ECO44
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3GUW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: April 22, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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