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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus pseudofirmus (strain OF4)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Synonyms:mdhAImported
Ordered Locus Names:BpOF4_03355Imported
OrganismiBacillus pseudofirmus (strain OF4)Imported
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001544 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi398511.BpOF4_03355

Structurei

3D structure databases

ProteinModelPortaliD3FWY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 147Ldh_1_NInterPro annotationAdd BLAST141
Domaini151 – 309Ldh_1_CInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

D3FWY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKRRKISV IGAGFTGATT ALMVAQKELG DVVLVDIPQL EGPTKGKALD
60 70 80 90 100
MLESTPVQGV DSNIIGTSSY EDTKDSDVVV ITAGIARKPG MSRDDLVSTN
110 120 130 140 150
AGIMKAVTKE VVKHSPNCYI IVLTNPADAM TYTVYKESGF PKNRVIGQSG
160 170 180 190 200
VLDTARFRTF VAQELNLSVE DITGFVLGGH GDDMVPLIRY SAAGGVPLEK
210 220 230 240 250
LIPKERIDEI VERTRKGGGE IVGLLGNGSA YYAPAASLAQ MVEAILKDKK
260 270 280 290 300
RVIPTIAYLE GEYGYEDLYA GVPTILGGDG IEKVIELDLT DEEKSALEKS
310
VESIRNVMQA LPND
Length:314
Mass (Da):33,607
Last modified:March 23, 2010 - v1
Checksum:i8CC11DA0FF368C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001878 Genomic DNA Translation: ADC48737.1
RefSeqiWP_012960014.1, NC_013791.2

Genome annotation databases

EnsemblBacteriaiADC48737; ADC48737; BpOF4_03355
KEGGibpf:BpOF4_03355

Similar proteinsi

Entry informationi

Entry nameiD3FWY2_BACPE
AccessioniPrimary (citable) accession number: D3FWY2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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