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Entry version 60 (12 Aug 2020)
Sequence version 1 (23 Mar 2010)
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Protein
Submitted name:

Cleavage and polyadenylation specific factor 1, 160kDa, isoform CRA_a

Gene

CPSF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cleavage and polyadenylation specific factor 1, 160kDa, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPSF1Imported
ORF Names:hCG_2039719Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
D3DWL9

PRoteomics IDEntifications database

More...
PRIDEi
D3DWL9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini996 – 1330CPSF_AInterPro annotationAdd BLAST335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni326 – 357DisorderedSequence analysisAdd BLAST32
Regioni468 – 492DisorderedSequence analysisAdd BLAST25
Regioni637 – 699DisorderedSequence analysisAdd BLAST63
Regioni823 – 843DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi330 – 345PolyampholyteSequence analysisAdd BLAST16
Compositional biasi823 – 840PolyampholyteSequence analysisAdd BLAST18

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
360328at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03178, CPSF_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DWL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMASVQLAG AKRDALLLSF KDAKLSVVEY DPGTHDLKTL SLHYFEEPEL
60 70 80 90 100
RDGFVQNVHT PRVRVDPDGR CAAMLVYGTR LVVLPFRRES LAEEHEGLVG
110 120 130 140 150
EGQRSSFLPS YIIDVRALDE KLLNIIDLQF LHGYYEPTLL ILFEPNQTWP
160 170 180 190 200
GRVAVRQDTC SIVAISLNIT QKVHPVIWSL TSLPFDCTQA LAVPKPIGGV
210 220 230 240 250
VVFAVNSLLY LNQSVPPYGV ALNSLTTGTT AFPLRTQEGV RITLDCAQAT
260 270 280 290 300
FISYDKMVIS LKGGEIYVLT LITDGMRSVR AFHFDKAAAS VLTTSMVTME
310 320 330 340 350
PGYLFLGSRL GNSLLLKYTE KLQEPPASAV REAADKEEPP SKKKRVDATA
360 370 380 390 400
GWSAAGKSVP QDEVDEIEVY GSEAQSGTQL ATYSFEVCDS ILNIGPCANA
410 420 430 440 450
AVGEPAFLSE EFQNSPEPDL EIVVCSGHGK NGALSVLQKS IRPQVVTTFE
460 470 480 490 500
LPGCYDMWTV IAPVRKEEED NPKGEGTEQE PSTTPEADDD GRRHGFLILS
510 520 530 540 550
REDSTMILQT GQEIMELDTS GFATQGPTVF AGNIGDNRYI VQVSPLGIRL
560 570 580 590 600
LEGVNQLHFI PVDLGAPIVQ CAVADPYVVI MSAEGHVTMF LLKSDSYGGR
610 620 630 640 650
HHRLALHKPP LHHQSKVITL CLYRDLSGMF TTESRLGGAR DELGGRSGPE
660 670 680 690 700
AEGLGSETSP TVDDEEEMLY GDSGSLFSPS KEEARRSSQP PADRDPAPFR
710 720 730 740 750
AEPTHWCLLV RENGTMEIYQ LPDWRLVFLV KNFPVGQRVL VDSSFGQPTT
760 770 780 790 800
QGEARREEAT RQGELPLVKE VLLVALGSRQ SRPYLLVHVD QELLIYEAFP
810 820 830 840 850
HDSQLGQGNL KVRFKKVPHN INFREKKPKP SKKKAEGGGA EEGAGARGRV
860 870 880 890 900
ARFRYFEDIY GYSGVFICGP SPHWLLVTGR GALRLHPMAI DGPVDSFAPF
910 920 930 940 950
HNVNCPRGFL YFNRQGELRI SVLPAYLSYD APWPVRKIPL RCTAHYVAYH
960 970 980 990 1000
VESKVYAVAT STNTPCARIP RMTGEEKEFE TIERDERYIH PQQEAFSIQL
1010 1020 1030 1040 1050
ISPVSWEAIP NARIELQEWE HVTCMKTVSL RSEETVSGLK GYVAAGTCLM
1060 1070 1080 1090 1100
QGEEVTCRGR ILIMDVIEVV PEPGQPLTKN KFKVLYEKEQ KGPVTALCHC
1110 1120 1130 1140 1150
NGHLVSAIGQ KIFLWSLRAS ELTGMAFIDT QLYIHQMISV KNFILAADVM
1160 1170 1180 1190 1200
KSISLLRYQE ESKTLSLVSR DAKPLEVYSV DFMVDNAQLG FLVSDRDRNL
1210 1220 1230 1240 1250
MVYMYLPEAK ESFGGMRLLR RADFHVGAHV NTFWRTPCRG ATEGLSKKSV
1260 1270 1280 1290 1300
VWENKHITWF ATLDGGIGLL LPMQEKTYRR LLMLQNALTT MLPHHAGLNP
1310 1320 1330 1340 1350
RAFRMLHVDR RTLQNAVRNV LDGELLNRYL YLSTMERSEL AKKIGTTPDI
1360
ILDDLLETDR VTAHF
Length:1,365
Mass (Da):151,986
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B2687215CDB51BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471162 Genomic DNA Translation: EAW82106.1
CH471162 Genomic DNA Translation: EAW82107.1
CH471162 Genomic DNA Translation: EAW82108.1

NCBI Reference Sequences

More...
RefSeqi
XP_006716612.1, XM_006716549.2
XP_011515299.1, XM_011516997.1
XP_011515300.1, XM_011516998.1
XP_011515301.1, XM_011516999.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471162 Genomic DNA Translation: EAW82106.1
CH471162 Genomic DNA Translation: EAW82107.1
CH471162 Genomic DNA Translation: EAW82108.1
RefSeqiXP_006716612.1, XM_006716549.2
XP_011515299.1, XM_011516997.1
XP_011515300.1, XM_011516998.1
XP_011515301.1, XM_011516999.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiD3DWL9
PRIDEiD3DWL9

Phylogenomic databases

OrthoDBi360328at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
29894, 613 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CPSF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29894

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF03178, CPSF_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DWL9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DWL9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: August 12, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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