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Entry version 56 (05 Jun 2019)
Sequence version 1 (23 Mar 2010)
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Protein
Submitted name:

Huntingtin (Huntington disease), isoform CRA_a

Gene

HD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Huntingtin (Huntington disease), isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDImported
ORF Names:hCG_1984846Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3DVR8

PRoteomics IDEntifications database

More...
PRIDEi
D3DVR8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni108 – 131DisorderedSequence analysisAdd BLAST24
Regioni631 – 680DisorderedSequence analysisAdd BLAST50
Regioni1785 – 1806DisorderedSequence analysisAdd BLAST22
Regioni2088 – 2117DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili896 – 916Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 127PolyampholyteSequence analysisAdd BLAST20
Compositional biasi660 – 680PolarSequence analysisAdd BLAST21
Compositional biasi1790 – 1804PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZV Eukaryota
ENOG410XSEC LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat

The PANTHER Classification System

More...
PANTHERi
PTHR10170 PTHR10170, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12372 DUF3652, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DVR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLNDGTQAS SPISDSSQTT TEGPDSAVTP SDSSEIVLDG TDNQYLGLQI
60 70 80 90 100
GQPQDEDEEA TGILPDEASE AFRNSSMALQ QAHLLKNMSH CRQPSDSSVD
110 120 130 140 150
KFVLRDEATE PGDQENKPCR IKGDIGQSTD DDSAPLVHCV RLLSASFLLT
160 170 180 190 200
GGKNVLVPDR DVRVSVKALA LSCVGAAVAL HPESFFSKLY KVPLDTTEYP
210 220 230 240 250
EEQYVSDILN YIDHGDPQVR GATAILCGTL ICSILSRSRF HVGDWMGTIR
260 270 280 290 300
TLTGNTFSLA DCIPLLRKTL KDESSVTCKL ACTAVRNCVM SLCSSSYSEL
310 320 330 340 350
GLQLIIDVLT LRNSSYWLVR TELLETLAEI DFRLVSFLEA KAENLHRGAH
360 370 380 390 400
HYTGLLKLQE RVLNNVVIHL LGDEDPRVRH VAAASLIRLV PKLFYKCDQG
410 420 430 440 450
QADPVVAVAR DQSSVYLKLL MHETQPPSHF SVSTITRIYR GYNLLPSITD
460 470 480 490 500
VTMENNLSRV IAAVSHELIT STTRALTFGC CEALCLLSTA FPVCIWSLGW
510 520 530 540 550
HCGVPPLSAS DESRKSCTVG MATMILTLLS SAWFPLDLSA HQDALILAGN
560 570 580 590 600
LLAASAPKSL RSSWASEEEA NPAATKQEEV WPALGDRALV PMVEQLFSHL
610 620 630 640 650
LKVINICAHV LDDVAPGPAI KAALPSLTNP PSLSPIRRKG KEKEPGEQAS
660 670 680 690 700
VPLSPKKGSE ASAASRQSDT SGPVTTSKSS SLGSFYHLPS YLKLHDVLKA
710 720 730 740 750
THANYKVTLD LQNSTEKFGG FLRSALDVLS QILELATLQD IGKCVEEILG
760 770 780 790 800
YLKSCFSREP MMATVCVQQL LKTLFGTNLA SQFDGLSSNP SKSQGRAQRL
810 820 830 840 850
GSSSVRPGLY HYCFMAPYTH FTQALADASL RNMVQAEQEN DTSGWFDVLQ
860 870 880 890 900
KVSTQLKTNL TSVTKNRADK NAIHNHIRLF EPLVIKALKQ YTTTTCVQLQ
910 920 930 940 950
KQVLDLLAQL VQLRVNYCLL DSDQVFIGFV LKQFEYIEVG QFRESEAIIP
960 970 980 990 1000
NIFFFLVLLS YERYHSKQII GIPKIIQLCD GIMASGRKAV THAIPALQPI
1010 1020 1030 1040 1050
VHDLFVLRGT NKADAGKELE TQKEVVVSML LRLIQYHQVL EMFILVLQQC
1060 1070 1080 1090 1100
HKENEDKWKR LSRQIADIIL PMLAKQQMHI DSHEALGVLN TLFEILAPSS
1110 1120 1130 1140 1150
LRPVDMLLRS MFVTPNTMAS VSTVQLWISG ILAILRVLIS QSTEDIVLSR
1160 1170 1180 1190 1200
IQELSFSPYL ISCTVINRLR DGDSTSTLEE HSEGKQIKNL PEETFSRFLL
1210 1220 1230 1240 1250
QLVGILLEDI VTKQLKVEMS EQQHTFYCQE LGTLLMCLIH IFKSGMFRRI
1260 1270 1280 1290 1300
TAAATRLFRS DGCGGSFYTL DSLNLRARSM ITTHPALVLL WCQILLLVNH
1310 1320 1330 1340 1350
TDYRWWAEVQ QTPKRHSLSS TKLLSPQMSG EEEDSDLAAK LGMCNREIVR
1360 1370 1380 1390 1400
RGALILFCDY VCQNLHDSEH LTWLIVNHIQ DLISLSHEPP VQDFISAVHR
1410 1420 1430 1440 1450
NSAASGLFIQ AIQSRCENLS TPTMLKKTLQ CLEGIHLSQS GAVLTLYVDR
1460 1470 1480 1490 1500
LLCTPFRVLA RMVDILACRR VEMLLAANLQ SSMAQLPMEE LNRIQEYLQS
1510 1520 1530 1540 1550
SGLAQRHQRL YSLLDRFRLS TMQDSLSPSP PVSSHPLDGD GHVSLETVSP
1560 1570 1580 1590 1600
DKDWYVHLVK SQCWTRSDSA LLEGAELVNR IPAEDMNAFM MNSEFNLSLL
1610 1620 1630 1640 1650
APCLSLGMSE ISGGQKSALF EAAREVTLAR VSGTVQQLPA VHHVFQPELP
1660 1670 1680 1690 1700
AEPAAYWSKL NDLFGDAALY QSLPTLARAL AQYLVVVSKL PSHLHLPPEK
1710 1720 1730 1740 1750
EKDIVKFVVA TLEALSWHLI HEQIPLSLDL QAGLDCCCLA LQLPGLWSVV
1760 1770 1780 1790 1800
SSTEFVTHAC SLIYCVHFIL EAVAVQPGEQ LLSPERRTNT PKAISEEEEE
1810 1820 1830 1840 1850
VDPNTQNPKY ITAACEMVAE MVESLQSVLA LGHKRNSGVP AFLTPLLRNI
1860 1870 1880 1890 1900
IISLARLPLV NSYTRVPPLV WKLGWSPKPG GDFGTAFPEI PVEFLQEKEV
1910 1920 1930 1940 1950
FKEFIYRINT LGWTSRTQFE ETWATLLGVL VTQPLVMEQE ESPPEEDTER
1960 1970 1980 1990 2000
TQINVLAVQA ITSLVLSAMT VPVAGNPAVS CLEQQPRNKP LKALDTRFGR
2010 2020 2030 2040 2050
KLSIIRGIVE QEIQAMVSKR ENIATHHLYQ AWDPVPSLSP ATTGALISHE
2060 2070 2080 2090 2100
KLLLQINPER ELGSMSYKLG QVSIHSVWLG NSITPLREEE WDEEEEEEAD
2110 2120 2130 2140 2150
APAPSSPPTS PVNSRKHRAG VDIHSCSQFL LELYSRWILP SSSARRTPAI
2160 2170 2180 2190 2200
LISEVVRSLL VVSDLFTERN QFELMYVTLT ELRRVHPSED EILAQYLVPA
2210 2220 2230 2240 2250
TCKAAAVLGM DKAVAEPVSR LLESTLRSSH LPSRVGALHG VLYVLECDLL
2260 2270 2280 2290 2300
DDTAKQLIPV ISDYLLSNLK GIAHCVNIHS QQHVLVMCAT AFYLIENYPL
2310 2320 2330 2340 2350
DVGPEFSASI IQMCGVMLSG SEESTPSIIY HCALRGLERL LLSEQLSRLD
2360 2370 2380 2390 2400
AESLVKLSVD RVNVHSPHRA MAALGLMLTC MYTGKEKVSP GRTSDPNPAA
2410 2420 2430 2440 2450
PDSESVIVAM ERVSVLFDRI RKGFPCEARV VARILPQFLD DFFPPQDIMN
2460 2470 2480 2490 2500
KVIGEFLSNQ QPYPQFMATV VYKVFQTLHS TGQSSMVRDW VMLSLSNFTQ
2510 2520 2530 2540 2550
RAPVAMATWS LSCFFVSAST SPWVAAILPH VISRMGKLEQ VDVNLFCLVA
2560 2570 2580 2590
TDFYRHQIEE ELDRRAFQSV LEVVAAPGSP YHRLLTCLRN VHKVTTC
Length:2,597
Mass (Da):288,265
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BDF1443A534BCC9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471131 Genomic DNA Translation: EAW82474.1
CH471131 Genomic DNA Translation: EAW82477.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471131 Genomic DNA Translation: EAW82474.1
CH471131 Genomic DNA Translation: EAW82477.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiD3DVR8
PRIDEiD3DVR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IDZV Eukaryota
ENOG410XSEC LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HTT human

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat
PANTHERiPTHR10170 PTHR10170, 1 hit
PfamiView protein in Pfam
PF12372 DUF3652, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DVR8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DVR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 5, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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