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Protein
Submitted name:

RAR-related orphan receptor C, isoform CRA_a

Gene

RORC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi84 – 159Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RAR-related orphan receptor C, isoform CRA_aImported
Gene namesi
Name:RORCImported
ORF Names:hCG_16918Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiD3DV25
PRIDEiD3DV25

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 159Nuclear receptorInterPro annotationAdd BLAST76
Domaini325 – 564NR LBDInterPro annotationAdd BLAST240

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili167 – 187Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4216 Eukaryota
ENOG410XUGR LUCA
HOGENOMiHOG000010200

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003079 ROR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01293 RORNUCRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3DV25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPGARTLC QPLLFPACWR ARCSRLPPSA LLPPLGPAPC PPGQPGQPGR
60 70 80 90 100
HQGSCPMDRA PQRQHRASRE LLAAKKTHTS QIEVIPCKIC GDKSSGIHYG
110 120 130 140 150
VITCEGCKGF FRRSQRCNAA YSCTRQQNCP IDRTSRNRCQ HCRLQKCLAL
160 170 180 190 200
GMSRDAVKFG RMSKKQRDSL HAEVQKQLQQ RQQQQQEPVV KTPPAGAQGA
210 220 230 240 250
DTLTYTLGLP DGQLPLGSSP DLPEASACPP GLLKASGSGP SYSNNLAKAG
260 270 280 290 300
LNGASCHLEY SPERGKAEGR ESFYSTGSQL TPDRCGLRFE EHRHPGLGEL
310 320 330 340 350
GQGPDSYGSP SFRSTPEAPY ASLTEIEHLV QSVCKSYRET CQLRLEDLLR
360 370 380 390 400
QRSNIFSREE VTGYQRKSMW EMWERCAHHL TEAIQYVVEF AKRLSGFMEL
410 420 430 440 450
CQNDQIVLLK AGAMEVVLVR MCRAYNADNR TVFFEGKYGG MELFRALGCS
460 470 480 490 500
ELISSIFDFS HSLSALHFSE DEIALYTALV LINAHRPGLQ EKRKVEQLQY
510 520 530 540 550
NLELAFHHHL CKTHRQSILA KLPPKGKLRS LCSQHVERLQ IFQHLHPIVV
560 570
QAAFPPLYKE LFSTETESPV GLSK
Length:574
Mass (Da):64,002
Last modified:March 23, 2010 - v1
Checksum:i6B030389AA0656A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471121 Genomic DNA Translation: EAW53405.1
CH471121 Genomic DNA Translation: EAW53406.1
UniGeneiHs.256022
Hs.607993

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471121 Genomic DNA Translation: EAW53405.1
CH471121 Genomic DNA Translation: EAW53406.1
UniGeneiHs.256022
Hs.607993

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiD3DV25
PRIDEiD3DV25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4216 Eukaryota
ENOG410XUGR LUCA
HOGENOMiHOG000010200

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003079 ROR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01293 RORNUCRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3DV25_HUMAN
AccessioniPrimary (citable) accession number: D3DV25
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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