Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 51 (02 Jun 2021)
Sequence version 1 (23 Mar 2010)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Polycystic kidney disease 1-like 2, isoform CRA_a

Gene

PKD1L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polycystic kidney disease 1-like 2, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKD1L2Imported
ORF Names:hCG_1649464Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1260 – 1279HelicalSequence analysisAdd BLAST20
Transmembranei1467 – 1488HelicalSequence analysisAdd BLAST22
Transmembranei1508 – 1529HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501011157118 – 1694Sequence analysisAdd BLAST1677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 153C-type lectinInterPro annotationAdd BLAST119
Domaini336 – 1037REJInterPro annotationAdd BLAST702
Domaini1193 – 1242GPSInterPro annotationAdd BLAST50
Domaini1304 – 1421PLATInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1539 – 1563DisorderedSequence analysisAdd BLAST25
Regioni1638 – 1658DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1539 – 1558Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.ARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752, PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000203, GPS
IPR043159, Lectin_gal-bd_sf
IPR002859, PKD/REJ-like
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825, GPS, 1 hit
PF00059, Lectin_C, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 1 hit
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723, SSF49723, 1 hit
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS50221, GPS, 1 hit
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DUL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAVGLVLLV LALRLRATTV KPEEGSFCSN SQVAFRDACY EFVPLGRTFR
60 70 80 90 100
DAQSWCEGQG GHLVFIQDEG TQRFLQNHIS QDREWWIGLT WNLARNGTTE
110 120 130 140 150
GPGTWLDTSN VTYSNWHGGQ AAAAPDTCGH IGRGPSSEWV TSDCAQTFAF
160 170 180 190 200
MCEFRVGQSL ACEGLNATVH CGLGQVIQVQ DAIYGRQNPH FCTQDAGRPS
210 220 230 240 250
DLEQGCSWAN VKEEVAGVSS NVTHQFTSPG EFTVFAECTT SEWHVTAQRQ
260 270 280 290 300
VTVRDKMETL SVTACSGLSQ SGAGPLCQAV FGDPLWIQVE LDGGTGVTYT
310 320 330 340 350
VLLGDITLAE STTQKGSLPY NLILDRETQQ LMGPGRHRLE IQATGNTTTS
360 370 380 390 400
TISRNITVHL VELLSGLQAS WASDHLELGQ DLLITISLAQ GTPEELTFEV
410 420 430 440 450
AGLNATFSHE QVSFGEPFGI CRLAVLVEGT FLVTMLVRNA FSNLSLEIGN
460 470 480 490 500
ITITAPSGLQ EPSGMNAEGK SKDKGDMEVY IQPGPYVDPF TTVTLGWPDN
510 520 530 540 550
DKELRFQWSC GSCWALWSSC VERQLLRTDQ RELVVPASCL PPPDSAVTLR
560 570 580 590 600
LAVLRGQELE NRAEQCLYVS APWELRPRVS CERNCRPVNA SKDILLRVTM
610 620 630 640 650
GEDSPVAMFS WYLDNTPTEQ AEPLPDACRL RGFWPRSLTL LQSNTSTLLL
660 670 680 690 700
NSSFLQSRGE VIRIRATALT RHAYGEDTYV ISTVPPREVP ACTIAPEEGT
710 720 730 740 750
VLTSFAIFCN ASTALGPLEF CFCLESGSCL HCGPEPALPS VYLPLGEENN
760 770 780 790 800
DFVLTVVISA TNRAGDTQQT QAMAKVALGD TCVEDVAFQA AVSEKIPTAL
810 820 830 840 850
QGEGGPEQLL QLAKAVSSML NQEHESQGSG QSLSIDVRQK VREHVLGSLS
860 870 880 890 900
AVTTGLEDVQ RVQELAEVLR EVTCRSKELT PSAQWEASLA LQHASEALLT
910 920 930 940 950
VSAKARPEDQ RRQAATRDLF QAVGSVLEAS LSNRPEEPAE ASSSQIATVL
960 970 980 990 1000
RLLRVMEHVQ TALLLGKLPG GLPAMLATPS ISVYTNRIQP WSWQGSSLRP
1010 1020 1030 1040 1050
DAADSATFML PAASSLSSLE GGQEPVDIKI MSFPKSPFPA RSHFDVSGTV
1060 1070 1080 1090 1100
GGLRVTSPSG QLIPVKNLSE NIEILLPRHS QRHSQPTVLN LTSPEALWVN
1110 1120 1130 1140 1150
VTSGEATLGI QLHWRPDIAL TLSLGYGYHP NKSSYDAQTH LVPMVAPDEL
1160 1170 1180 1190 1200
PTWILSPQDL RFGEGVYYLT VVPESDLEPA PGRDLTVGIT TFLSHCVFWD
1210 1220 1230 1240 1250
EVQETWDDSG CQVGPRTSPY QTHCLCNHLT FFGSTFLVMP NAIDIHQTAE
1260 1270 1280 1290 1300
LFATFEDNPV VVTTVGCLCV VYVLVVIWAR RKDAQDQAKV KVTVLEDNDP
1310 1320 1330 1340 1350
FAQYHYLVTV YTGHRRGAAT SSKVTVTLYG LDGEREPHHL ADPDTPVFER
1360 1370 1380 1390 1400
GAVDAFLLST LFPLGELRSL RLWHDNSGDR PSWYVSRVLV YDLVMDRKWY
1410 1420 1430 1440 1450
FLCNSWLSIN VGDCVLDKVF PVATEQDRKQ FSHLFFMKTS AGFQDGHIWY
1460 1470 1480 1490 1500
SIFSRCARSS FTRVQRVSCC FSLLLCTMLT SIMFWGVPKD PAEQKMDLGK
1510 1520 1530 1540 1550
IEFTWQEVMI GLESSILMFP INLLIVQIFQ NTRPRVAKEQ NTGKWDRGSP
1560 1570 1580 1590 1600
NLTPSPQPME DGLLTPEAVT KDVSRIVSSL FKALKVPSPA LGWDSVNLMD
1610 1620 1630 1640 1650
INSLLALVED VIYPHNTSGQ VFWEEAKKRE DPVTLTLGSS EMKEKSQCPK
1660 1670 1680 1690
PKAARSGPWK DSAYRQCLYL QLEHVEQELR LVGPRGFSQP HSHA
Length:1,694
Mass (Da):186,449
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i680D3EB577C4CB71
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471114 Genomic DNA Translation: EAW95539.1
CH471114 Genomic DNA Translation: EAW95540.1
CH471114 Genomic DNA Translation: EAW95544.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471114 Genomic DNA Translation: EAW95539.1
CH471114 Genomic DNA Translation: EAW95540.1
CH471114 Genomic DNA Translation: EAW95544.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PKD1L2, human

Family and domain databases

CDDicd01752, PLAT_polycystin, 1 hit
Gene3Di2.60.120.740, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000203, GPS
IPR043159, Lectin_gal-bd_sf
IPR002859, PKD/REJ-like
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom
PfamiView protein in Pfam
PF01825, GPS, 1 hit
PF00059, Lectin_C, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SUPFAMiSSF49723, SSF49723, 1 hit
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS50221, GPS, 1 hit
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DUL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DUL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 2, 2021
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again