UniProtKB - D3DUC1 (D3DUC1_HUMAN)
Protein
Submitted name:
Zinc finger protein 263, isoform CRA_a
Gene
ZNF263
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger protein 263, isoform CRA_aImported |
Gene namesi | Name:ZNF263Imported ORF Names:hCG_2039169Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 123 | SCAN boxInterPro annotationAdd BLAST | 83 | |
Domaini | 217 – 289 | KRABInterPro annotationAdd BLAST | 73 | |
Domaini | 378 – 405 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 434 – 461 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 462 – 489 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 490 – 517 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 518 – 545 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 575 – 602 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 603 – 630 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 631 – 658 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 659 – 683 | C2H2-typeInterPro annotationAdd BLAST | 25 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 185 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 230 – 301 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 322 – 368 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 246 – 269 | PolarSequence analysisAdd BLAST | 24 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OMAi | NVEDKEM |
OrthoDBi | 1318335at2759 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR030752, ZNF263 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF224, PTHR23226:SF224, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
D3DUC1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ
60 70 80 90 100
EAAGPREALS RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR
110 120 130 140 150
VQELHPESGE EAVTLVEDMQ RELGRLRQQV TNHGRGTEVL LEEPLPLETA
160 170 180 190 200
RESPSFKLEP METERSPGPR LQELLGPSPQ RDPQAVKERA LSAPWLSLFP
210 220 230 240 250
PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA LSRDTVQESY
260 270 280 290 300
ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF
310 320 330 340 350
ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE
360 370 380 390 400
GGMEQALAGA SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH
410 420 430 440 450
AAERLCMGVD CTEIFGGNPR FLSLHRAHLG EEAHKCLECG KCFSQNTHLT
460 470 480 490 500
RHQRTHTGEK PYQCNICGKC FSCNSNLHRH QRTHTGEKPY KCPECGEIFA
510 520 530 540 550
HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH ERERLYPFSE
560 570 580 590 600
CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE
610 620 630 640 650
KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL
660 670 680
RTHTGERPYK CSECGESFSR SSRLMSHQRT HTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471112 Genomic DNA Translation: EAW85378.1 CH471112 Genomic DNA Translation: EAW85380.1 |
RefSeqi | XP_011520646.1, XM_011522344.1 |
Genome annotation databases
GeneIDi | 10127 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471112 Genomic DNA Translation: EAW85378.1 CH471112 Genomic DNA Translation: EAW85380.1 |
RefSeqi | XP_011520646.1, XM_011522344.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 10127 |
Genome annotation databases
GeneIDi | 10127 |
Organism-specific databases
CTDi | 10127 |
Phylogenomic databases
OMAi | NVEDKEM |
OrthoDBi | 1318335at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10127, 7 hits in 1015 CRISPR screens |
ChiTaRSi | ZNF263, human |
GenomeRNAii | 10127 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR030752, ZNF263 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF224, PTHR23226:SF224, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3DUC1_HUMAN | |
Accessioni | D3DUC1Primary (citable) accession number: D3DUC1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 23, 2010 |
Last sequence update: | March 23, 2010 | |
Last modified: | April 7, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |