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Entry version 58 (16 Oct 2019)
Sequence version 1 (23 Mar 2010)
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Protein
Submitted name:

G protein-coupled receptor 124, isoform CRA_a

Gene

GPR124

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
G protein-coupled receptor 124, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR124Imported
ORF Names:hCG_23113Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei772 – 793HelicalSequence analysisAdd BLAST22
Transmembranei805 – 826HelicalSequence analysisAdd BLAST22
Transmembranei898 – 920HelicalSequence analysisAdd BLAST23
Transmembranei989 – 1009HelicalSequence analysisAdd BLAST21
Transmembranei1015 – 1037HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501011156434 – 1308Sequence analysisAdd BLAST1275

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3DSW5

PRoteomics IDEntifications database

More...
PRIDEi
D3DSW5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini260 – 344Ig-likeInterPro annotationAdd BLAST85
Domaini327 – 421G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST95
Domaini707 – 758GPSInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni565 – 591DisorderedSequence analysisAdd BLAST27
Regioni928 – 961DisorderedSequence analysisAdd BLAST34
Regioni1058 – 1096DisorderedSequence analysisAdd BLAST39
Regioni1120 – 1166DisorderedSequence analysisAdd BLAST47
Regioni1188 – 1279DisorderedSequence analysisAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi574 – 588Pro-richSequence analysisAdd BLAST15
Compositional biasi1141 – 1158BasicSequence analysisAdd BLAST18
Compositional biasi1188 – 1210PolarSequence analysisAdd BLAST23

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Database of Orthologous Groups

More...
OrthoDBi
31536at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825 GPS, 1 hit
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DSW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER
60 70 80 90 100
PKGLSGGVPG PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR
110 120 130 140 150
NGSFLGLSLL EKLDLRNNII STVQPGAFLG LGELKRLDLS NNRIGCLTSE
160 170 180 190 200
TFQGLPRLLR LNISGNIFSS LQPGVFDELP ALKVVDLGTE FLTCDCHLRW
210 220 230 240 250
LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE GALELHTHHL
260 270 280 290 300
IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE
310 320 330 340 350
SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA
360 370 380 390 400
SYCPAERVAN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS
410 420 430 440 450
RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY
460 470 480 490 500
TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH
510 520 530 540 550
LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN VALEAYLIKP
560 570 580 590 600
HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR
610 620 630 640 650
PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN
660 670 680 690 700
GRLFHSHSNT SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR
710 720 730 740 750
HWAEGAEPVA AWWSQEGPGE AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA
760 770 780 790 800
VLMELSAFPR EVGGAGAGLH PVVYPCTALL LLCLFATIIT YILNHSSIRV
810 820 830 840 850
SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI TLHYSSLSTL
860 870 880 890 900
LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRCWLV WRPSLGAFYI
910 920 930 940 950
PVALILLITW IYFLCAGLRL RGPLAQNPKA GNSRASLEAG EELRGSTRLR
960 970 980 990 1000
GSGPLLSDSG SLLATGSARV GTPGPPEDGD SLYSPGVQLG ALVTTHFLYL
1010 1020 1030 1040 1050
AMWACGALAV SQRWLPRVVC SCLYGVAASA LGLFVFTHHC ARRRDVRASW
1060 1070 1080 1090 1100
RACCPPASPA APHAPPRALP AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA
1110 1120 1130 1140 1150
LGPCKLTNLQ LAQSQVCEAG AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR
1160 1170 1180 1190 1200
RAHKSRAKGH RAGEACGKNR LKALRGGAAG ALELLSSESG SLHNSPTDSY
1210 1220 1230 1240 1250
LGSSRNSPGA GLQLEGEPML TPSEGSDTSA APLSEAGRAG QRRSASRDSL
1260 1270 1280 1290 1300
KGGGALEKES HRRSYPLNAA SLNGAPKGGK YDDVTLMGAE VASGGCMKTG

LWKSETTV
Length:1,308
Mass (Da):139,363
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i745AB6E143F463A7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471080 Genomic DNA Translation: EAW63354.1
CH471080 Genomic DNA Translation: EAW63359.1

NCBI Reference Sequences

More...
RefSeqi
XP_011542785.1, XM_011544483.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471080 Genomic DNA Translation: EAW63354.1
CH471080 Genomic DNA Translation: EAW63359.1
RefSeqiXP_011542785.1, XM_011544483.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiD3DSW5
PRIDEiD3DSW5

Genome annotation databases

GeneIDi25960

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25960

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
OrthoDBi31536at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRA2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25960

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF01825 GPS, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DSW5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DSW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: October 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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