UniProtKB - D3DSW5 (D3DSW5_HUMAN)
Protein
Submitted name:
G protein-coupled receptor 124, isoform CRA_a
Gene
GPR124
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: InterPro
Keywordsi
Molecular function | ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: G protein-coupled receptor 124, isoform CRA_aImported |
Gene namesi | Name:GPR124Imported ORF Names:hCG_23113Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 772 – 793 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 805 – 826 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 898 – 920 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 989 – 1009 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1015 – 1037 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_5010111564 | 34 – 1308 | Sequence analysisAdd BLAST | 1275 |
Keywords - PTMi
Disulfide bondARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 260 – 344 | Ig-likeInterPro annotationAdd BLAST | 85 | |
Domaini | 327 – 421 | G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST | 95 | |
Domaini | 707 – 758 | GPSInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 565 – 591 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 928 – 961 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1058 – 1096 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1120 – 1166 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 1188 – 1279 | DisorderedSequence analysisAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 574 – 588 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1141 – 1158 | BasicSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1188 – 1210 | PolarSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Leucine-rich repeatARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 31536at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR007110, Ig-like_dom IPR013783, Ig-like_fold IPR003599, Ig_sub IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF01825, GPS, 1 hit PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50221, GPS, 1 hit PS50835, IG_LIKE, 1 hit PS51450, LRR, 4 hits |
i Sequence
Sequence statusi: Complete.
D3DSW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER
60 70 80 90 100
PKGLSGGVPG PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR
110 120 130 140 150
NGSFLGLSLL EKLDLRNNII STVQPGAFLG LGELKRLDLS NNRIGCLTSE
160 170 180 190 200
TFQGLPRLLR LNISGNIFSS LQPGVFDELP ALKVVDLGTE FLTCDCHLRW
210 220 230 240 250
LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE GALELHTHHL
260 270 280 290 300
IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE
310 320 330 340 350
SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA
360 370 380 390 400
SYCPAERVAN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS
410 420 430 440 450
RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY
460 470 480 490 500
TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH
510 520 530 540 550
LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN VALEAYLIKP
560 570 580 590 600
HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR
610 620 630 640 650
PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN
660 670 680 690 700
GRLFHSHSNT SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR
710 720 730 740 750
HWAEGAEPVA AWWSQEGPGE AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA
760 770 780 790 800
VLMELSAFPR EVGGAGAGLH PVVYPCTALL LLCLFATIIT YILNHSSIRV
810 820 830 840 850
SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI TLHYSSLSTL
860 870 880 890 900
LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRCWLV WRPSLGAFYI
910 920 930 940 950
PVALILLITW IYFLCAGLRL RGPLAQNPKA GNSRASLEAG EELRGSTRLR
960 970 980 990 1000
GSGPLLSDSG SLLATGSARV GTPGPPEDGD SLYSPGVQLG ALVTTHFLYL
1010 1020 1030 1040 1050
AMWACGALAV SQRWLPRVVC SCLYGVAASA LGLFVFTHHC ARRRDVRASW
1060 1070 1080 1090 1100
RACCPPASPA APHAPPRALP AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA
1110 1120 1130 1140 1150
LGPCKLTNLQ LAQSQVCEAG AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR
1160 1170 1180 1190 1200
RAHKSRAKGH RAGEACGKNR LKALRGGAAG ALELLSSESG SLHNSPTDSY
1210 1220 1230 1240 1250
LGSSRNSPGA GLQLEGEPML TPSEGSDTSA APLSEAGRAG QRRSASRDSL
1260 1270 1280 1290 1300
KGGGALEKES HRRSYPLNAA SLNGAPKGGK YDDVTLMGAE VASGGCMKTG
LWKSETTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471080 Genomic DNA Translation: EAW63354.1 CH471080 Genomic DNA Translation: EAW63359.1 |
RefSeqi | XP_011542785.1, XM_011544483.2 |
Genome annotation databases
GeneIDi | 25960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471080 Genomic DNA Translation: EAW63354.1 CH471080 Genomic DNA Translation: EAW63359.1 |
RefSeqi | XP_011542785.1, XM_011544483.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 25960 |
Organism-specific databases
CTDi | 25960 |
Phylogenomic databases
OrthoDBi | 31536at2759 |
Miscellaneous databases
BioGRID-ORCSi | 25960, 3 hits in 875 CRISPR screens |
ChiTaRSi | ADGRA2, human |
GenomeRNAii | 25960 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR007110, Ig-like_dom IPR013783, Ig-like_fold IPR003599, Ig_sub IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF01825, GPS, 1 hit PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50221, GPS, 1 hit PS50835, IG_LIKE, 1 hit PS51450, LRR, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3DSW5_HUMAN | |
Accessioni | D3DSW5Primary (citable) accession number: D3DSW5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 23, 2010 |
Last sequence update: | March 23, 2010 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |