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Entry version 81 (02 Jun 2021)
Sequence version 1 (23 Mar 2010)
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Protein
Submitted name:

Collagen, type XVIII, alpha 1, isoform CRA_b

Gene

COL18A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type XVIII, alpha 1, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL18A1Imported
ORF Names:hCG_1647196Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501011156124 – 1516Sequence analysisAdd BLAST1493

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 409LAM_G_DOMAINInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 104DisorderedSequence analysisAdd BLAST63
Regioni152 – 219DisorderedSequence analysisAdd BLAST68
Regioni410 – 1205DisorderedSequence analysisAdd BLAST796
Regioni1273 – 1318DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 75Polar residuesSequence analysisAdd BLAST22
Compositional biasi157 – 183Polar residuesSequence analysisAdd BLAST27
Compositional biasi189 – 211Pro residuesSequence analysisAdd BLAST23
Compositional biasi481 – 505Polar residuesSequence analysisAdd BLAST25
Compositional biasi529 – 556Pro residuesSequence analysisAdd BLAST28
Compositional biasi564 – 578Pro residuesSequence analysisAdd BLAST15
Compositional biasi626 – 640Pro residuesSequence analysisAdd BLAST15
Compositional biasi668 – 682Pro residuesSequence analysisAdd BLAST15
Compositional biasi703 – 727Pro residuesSequence analysisAdd BLAST25
Compositional biasi769 – 787Pro residuesSequence analysisAdd BLAST19
Compositional biasi1018 – 1034Pro residuesSequence analysisAdd BLAST17
Compositional biasi1085 – 1102Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1117 – 1131Pro residuesSequence analysisAdd BLAST15
Compositional biasi1140 – 1199Pro residuesSequence analysisAdd BLAST60
Compositional biasi1278 – 1292Basic and acidic residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenImportedARBA annotation, SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247, Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR010363, DUF959_COL18_N
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 5 hits
PF06121, DUF959, 1 hit
PF06482, Endostatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DSM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPYPCGCHI LLLLFCCLAA ARANLLNLNW LWFNNEDTSH AATTIPEPQG
60 70 80 90 100
PLPVQPTADT TTHVTPRNGS TEPATAPGSP EPPSELLEDG QDTPTSAESP
110 120 130 140 150
DAPEENIAGV GAEILNVAKG IRSFVQLWND TVPTESLARA ETLVLETPVG
160 170 180 190 200
PLALAGPSST PQENGTTLWP SRGIPSSPGA HTTEAGTLPA PTPSPPSLGR
210 220 230 240 250
PWAPLTGPSV PPPSSERISE EVGLLQLLGD PPPQQVTQTD DPDVGLAYVF
260 270 280 290 300
GPDANSGQVA RYHFPSLFFR DFSLLFHIRP ATEGPGVLFA ITDSAQAMVL
310 320 330 340 350
LGVKLSGVQD GHQDISLLYT EPGAGQTHTA ASFRLPAFVG QWTHLALSVA
360 370 380 390 400
GGFVALYVDC EEFQRMPLAR SSRGLELEPG AGLFVAQAGG ADPDKFQGVI
410 420 430 440 450
AELKVRRDPQ VSPMHCLDEE GDDSDGASGD SGSGLGDARE LLREETGAAL
460 470 480 490 500
KPRLPAPPPV TTPPLAGGSS TEDSRSEEVE EQTTVASLGA QTLPGSDSVS
510 520 530 540 550
TWDGSVRTPG GRVKEGGLKG QKGEPGVPGP PGRAGPPGSP CLPGPPGLPC
560 570 580 590 600
PVSPLGPAGP ALQTVPGPQG PPGPPGRDGT PGRDGEPGDP GEDGKPGDTG
610 620 630 640 650
PQGFPGTPGD VGPKGDKGDP GVGERGPPGP QGPPGPPGPS FRHDKLTFID
660 670 680 690 700
MEGSGFGGDL EALRGPRGFP GPPGPPGVPG LPGEPGRFGV NSSDVPGPAG
710 720 730 740 750
LPGVPGREGP PGFPGLPGPP GPPGREGPPG RTGQKGSLGE AGAPGHKGSK
760 770 780 790 800
GAPGPAGARG ESGLAGAPGP AGPPGPPGPP GPPGPGLPAG FDDMEGSGGP
810 820 830 840 850
FWSTARSADG PQGPPGLPGL KGDPGVPGLP GAKGEVGADG VPGFPGLPGR
860 870 880 890 900
EGIAGPQGPK GDRGSRGEKG DPGKDGVGQP GLPGPPGPPG PVVYVSEQDG
910 920 930 940 950
SVLSVPGPEG RPGFAGFPGP AGPKGNLGSK GERGSPGPKG EKGEPGSIFS
960 970 980 990 1000
PDGGALGPAQ KGAKGEPGFR GPPGPYGRPG YKGEIGFPGR PGRPGMNGLK
1010 1020 1030 1040 1050
GEKGEPGDAS LGFGMRGMPG PPGPPGPPGP PGTPVYDSNV FAESSRPGPP
1060 1070 1080 1090 1100
GLPGNQGPPG PKGAKGEVGP PGPPGQFPFD FLQLEAEMKG EKGDRGDAGQ
1110 1120 1130 1140 1150
KGERGEPGGG GFFGSSLPGP PGPPGPRGYP GIPGPKGESI RGQPGPPGPQ
1160 1170 1180 1190 1200
GPPGIGYEGR QGPPGPPGPP GPPSFPGPHR QTISVPGPPG PPGPPGPPGT
1210 1220 1230 1240 1250
MGASSGVRLW ATRQAMLGQV HEVPEGWLIF VAEQEELYVR VQNGFRKVQL
1260 1270 1280 1290 1300
EARTPLPRGT DNEVAALQPP VVQLHDSNPY PRREHPHPTA RPWRADDILA
1310 1320 1330 1340 1350
SPPRLPEPQP YPGAPHHSSY VHLRPARPTS PPAHSHRDFQ PVLHLVALNS
1360 1370 1380 1390 1400
PLSGGMRGIR GADFQCFQQA RAVGLAGTFR AFLSSRLQDL YSIVRRADRA
1410 1420 1430 1440 1450
AVPIVNLKDE LLFPSWEALF SGSEGPLKPG ARIFSFDGKD VLRHPTWPQK
1460 1470 1480 1490 1500
SVWHGSDPNG RRLTESYCET WRTEAPSATG QASSLLGGRL LGQSAASCHH
1510
AYIVLCIENS FMTASK
Length:1,516
Mass (Da):153,767
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CE0B6A21DAC50D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471079 Genomic DNA Translation: EAX09339.1
CH471079 Genomic DNA Translation: EAX09344.1

NCBI Reference Sequences

More...
RefSeqi
NP_085059.2, NM_030582.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80781

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471079 Genomic DNA Translation: EAX09339.1
CH471079 Genomic DNA Translation: EAX09344.1
RefSeqiNP_085059.2, NM_030582.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80781

Genome annotation databases

GeneIDi80781

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80781

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80781, 4 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL18A1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80781

Family and domain databases

CDDicd00247, Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR010363, DUF959_COL18_N
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01391, Collagen, 5 hits
PF06121, DUF959, 1 hit
PF06482, Endostatin, 1 hit
SMARTiView protein in SMART
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DSM5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DSM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 2, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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